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Primary hypothyroidism presenting as neuropsychiatric symptoms and pituitary enlargement in a young woman: illustrative case

Shanzay Haider, Kelsey Templeton, S. Bulent Omay, and Silvio E. Inzucchi

Enlargement of the sellar contents in an adult patient is most often associated with neoplasia, with pituitary adenomas accounting for approximately 80%–90% of all such masses. 1 , 2 In fact there is a high prevalence of nonfunctioning, benign pituitary adenomas, the vast majority being microadenomas, reported in up to 20% in the general population. 2–4 Other pathological causes of pituitary enlargement include cysts, craniopharyngiomas, or meningiomas. However, physiological enlargement of the pituitary gland can also occur, stemming from several causes