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Long-term survival in patients with long-segment complex meningiomas occluding the dural venous sinuses: illustrative cases

Zhishuo Wei, Arka N. Mallela, Andrew Faramand, Ajay Niranjan, and L. Dade Lunsford

trigeminal neuralgia (TGN) 24 months after her craniotomy and was treated with SRS for management of her facial pain. She underwent repeat SRS 120 months after the initial craniotomy for recurrent tumor. Repeat trigeminal GK SRS was performed three times for recurrent pain. At 243 months after the initial craniotomy, her tumor and facial pain were stable. B: The radiosurgery dose plan projected on the axial, coronal, and sagittal views for stages 1, 2, and 3 of the first and second SRS. The 214-month follow-up MRI after first GK shows stable tumor. Images obtained 2

Open access

Salvage pemetrexed for brain metastases from ALK-positive lung cancer after Gamma Knife radiosurgery: illustrative case

Ryuichi Noda, Atsuya Akabane, Mariko Kawashima, Masafumi Segawa, Sho Tsunoda, and Tomohiro Inoue

appearing in the pituitary gland ( Fig. 1L and M ). Eventually, trigeminal neuralgia resulted from direct invasion of the cranial nerve ( Fig. 1N ). Brigatinib was replaced with four courses of pemetrexed (150 mg/m 2 ) with carboplatin (320 mg/m 2 ), followed by pemetrexed maintenance (150 mg/m 2 ), based on the association between ALK -positive lung adenocarcinoma and durable responses to pemetrexed. The recurrent tumor and pituitary metastasis showed an immediate response to cytotoxic chemotherapy and were kept under control for the next 17 months ( Fig. 2 ). The