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lung cancer. Surgical intervention is often required to stabilize the spine, and these procedures can have significant morbidity that could be avoided with prevention or containment of the metastases by therapeutics. To date, this condition has not been replicated in a pre-clinical animal model, which would greatly aid the study of potential interventions. Methods Twenty-seven athymic rats underwent transperitoneal exposure and injection of 50,000 luciferase-labeled A549 lung cancer cells into the L5 vertebral body. At 4 weeks post-implantation, in vivo