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DNA methylation profiling of a lipomatous meningioma: illustrative case

Zeel Patel, Justin Z. Wang, Zamir Merali, Vikas Patil, Farshad Nassiri, Qingxia Wei, Julio Sosa, Claire Coire, and Gelareh Zadeh

Meningiomas are the most common primary intracranial tumor, comprising approximately one-third of all brain tumors. Symptoms can vary depending on the size and anatomical location of the tumor but can include headaches, seizures, neurological deficits, and behavioral changes. 1 These tumors are identified usually through magnetic resonance imaging (MRI) or computed tomography (CT), often following the development of neurological symptoms or incidentally in asymptomatic patients on imaging obtained for other clinical purposes. 2 While molecular profiling

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Cerebral arterial vasospasm complicating supratentorial meningioma resection: illustrative cases

Andrew C Pickles, John T Tsiang, Alexandria A Pecoraro, Nathan C Pecoraro, Ronak H Jani, Brandon J Bond, Anand V Germanwala, Joseph C Serrone, and Vikram C Prabhu

Meningiomas are the most frequently diagnosed primary tumor of the central nervous system. 1 , 2 Resection of meningiomas is the first-line treatment, with the extent of removal being inversely related to the rate of recurrence. 3 Preservation of the arachnoid plane around a meningioma facilitates a more complete resection with avoidance of injury to the adjacent cortex. However, at times, pial or brain invasion may complicate identification of the tumor margin. 4 In addition, meningiomas parasitize pial and cortical vessels and can be densely adherent

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Rare case of extracranial chordoid meningioma adjacent to the carotid sheath: illustrative case

Seung W. Jeong, Michael Moran, Shahed Elhamdani, Dorian M. Kusyk, Chen Xu, Kymberly Gyure, and Richard Williamson

Meningiomas are the most common benign tumors arising from within the central nervous system (CNS), comprising approximately 15% of intracranial and 25% of spinal tumors. 1 In rare cases (∼1%), they may arise outside the CNS, 2 and only 0.1% are thought to have metastatic seeding from an intracranial primary tumor. 3 The World Health Organization (WHO) has defined 15 histological meningioma subtypes that fall into a 3-tier grading system that stratifies recurrence risk. 4 Chordoid meningiomas are a rare grade 2 variant with regional histological patterns

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Pediatric meningioma with rhabdoid features developed at the site of skull fracture: illustrative case

Sho Takata, Akira Tamase, Yasuhiko Hayashi, Osamu Tachibana, Katsuaki Sato, and Hideaki Iizuka

Meningiomas account for approximately 20% of intracranial tumors and typically occur in adults. Pediatric meningiomas are rare, and their occurrence is reported to occur in 2.2% of all intracranial meningiomas. They tend to be associated with atypical locations, higher histopathological grades, and aggressive behaviors. 1 Tumorigenesis of a meningioma after head trauma has been deliberated upon for many years. 2–4 In 1938, post-traumatic meningioma was first described by Cushing and Eisenhardt, who reported a causal relationship between head trauma

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Meningioma with holo-sagittal sinus involvement treated successfully with intrinsic sinus surgery: illustrative case

Megan Rajagopal, Jamie Toms, and R. Scott Graham

Meningiomas account for about one-third of all central nervous system tumors. 1 The most common locations are the cerebral convexity (35%) and parasagittal (20%). 2 Meningiomas present a particular challenge when they involve bridging veins and major dural sinuses, as surgical removal may lead to venous congestion, brain swelling, and venous infarction. Parasagittal meningiomas have a grading classification described by Sindou. 3 , 4 Type I describes meningiomas that are attached to the outer surface of the sinus wall. In higher grades, types V and VI, the

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Successful treatment with urgent revascularization and parent artery occlusion for a ruptured intratumoral aneurysm following prior meningioma surgery: illustrative case

Tomohiro Okuyama, Kota Kurisu, Masaaki Hokari, Kei Miyata, Kazuki Uchida, Katsuyuki Asaoka, Koji Itamoto, and Miki Fujimura

pathogeneses of aneurysm development. Completely embedded intratumoral aneurysms are much rarer, 1 and their underlying pathogenesis and association with the surrounding tumor are unknown. Therefore, determining an optimal treatment strategy for such cases is complex. In this case report, we describe a rare case of an intratumoral aneurysm that developed 30 years after meningioma surgery, whose rupture resulted in a massive intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH). Rupture of this rare aneurysm is an additional rarity and requires urgent and

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Intratumoral abscess complicating a postradiation-induced World Health Organization grade II meningioma: illustrative case

Katherine Callahan, Isidora Beach, Sadie Casale, John DeWitt, and Bruce Tranmer

Meningiomas are the most commonly diagnosed benign primary brain mass, accounting for more than 35% of all brain neoplasms diagnosed annually. 1 In the Western world, brain abscesses occur at a rate of approximately 4 per 1 million annually and are most commonly due to infection by Staphylococcus or Streptococcus bacteria. 2 Peritumoral abscesses are historically associated with intra- or parasellar tumors and have predominantly originated from direct contact with the prenasal sinuses. 3 However, in most reported cases of meningioma-associated abscess

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Hemiparkinsonism caused by a lateral sphenoid wing meningioma, with tractography analysis: illustrative case

Attill Saemann, Stefan Busch, Ethan Taub, Birgit Westermann, Cristina Granziera, Raphael Guzman, Luigi Mariani, Jehuda Soleman, and Jonathan Rychen

aneurysms, and chronic subdural hematoma. 3–6 Here, we present a rare case of a large lateral sphenoid wing meningioma causing hemiparkinsonism. Meningiomas are relatively common intracranial tumors, comprising 36.6% of all primary central nervous system (CNS) tumors with an overall incidence of 8.3 per 100,000 persons in the Western population. 7 The presenting symptoms of meningiomas, like other CNS tumors, depend upon their size and location. They are typically slow growing, and thus have an insidious symptom onset. When symptomatic, meningiomas typically present

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Mother and daughter with a SMARCE1 mutation resulting in a cervical clear cell meningioma at an identical location: illustrative cases

Valérie N. E. Schuermans, Ank van de Goor, Martinus P. G. Broen, and Toon F. M. Boselie

Meningiomas are tumors that arise from the dura mater and primarily occur in the brain and spinal cord. 1 Intradural extramedullary meningiomas are the most common, which account for approximately 45% of all intradural spinal tumors. 2 , 3 Extradural spinal meningiomas occur less frequently. 2 Meningiomas are generally benign tumors and are rarely malignant. Because these tumors grow slowly, symptoms often arise when the tumor is already fairly large. Meningiomas are commonly found in all regions of the skull and along the spinal cord. 3 , 4 The majority

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Fluorescence and immune-cell infiltration of nonneoplastic, postbrachytherapy brain tissue in 5-ALA–guided resection of recurrent anaplastic meningioma: illustrative case

Rishab Ramapriyan, Victoria E Clark, 1 PhD, Maria Martinez-Lage, Brian Hsueh, 1 PhD, Brian V Nahed, 1 MSc, William T Curry, Bryan D Choi, 1 PhD, Bob S Carter, and 1 PhD

5-Aminolevulinic acid (5-ALA) fluorescence-guided surgery (FGS) has gained prominence in recent years for its utility in high-grade glioma resection, allowing enhanced visualization and tumor removal. 1 The use of 5-ALA for meningioma surgery has also been reported. 2 Mechanistically, 5-ALA is preferentially taken up by cells of certain tumors, including meningiomas, and enters the heme biosynthesis pathway, where it is converted to heme precursor porphyrin PpIX, which then accumulates in cells due to various tumor-specific aberrations, such as altered