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Spontaneous intracranial hypotension complicated by diffuse cerebral edema and episodes of severely elevated intracranial pressure: illustrative case

Jeffrey P. Turnbull and Vittorio M. Morreale

–5 Although rare, a growing body of literature has described the potentially severe manifestations associated with SIH, including acute encephalopathy, coma, cerebral hemorrhage, and subdural hematomas. 6–9 Although the etiology of SIH is still relatively unknown, instability or structural defects in the dural membrane are largely regarded to be associated with CSF leakage. 2 , 5 Two inciting mechanisms that have been previously established are a history of mild physical trauma preceding symptoms and an underlying connective tissue disorder. 1 , 10 Upon surgical