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Noninvasive biomarkers in normal pressure hydrocephalus: evidence for the role of neuroimaging

A review

Andrew Tarnaris, Neil D. Kitchen, and Laurence D. Watkins

colleagues, 88 studying 21 patients with idiopathic and secondary NPH, concluded that a criterion for postoperative improvement is preoperative hemispheric CBF > 20 ml/100 g/ min in combination with an impaired vascular response to acetazolamide only in the periventricular white matter. When glycerol was administered in 22 patients with secondary NPH, pre- and postoperative rCBF increased by more than 20% in those who responded to surgery. 83 Glycerol acts by increasing cerebral perfusion pressure and improving microcirculation. In this last study no cut-off value for