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Hormone receptors in initially excised versus recurrent intracranial meningiomas

Abraham B. Rubinstein, David Loven, Abraham Geier, Eli Reichenthal, and Natan Gadoth

T he presence of receptors for steroid hormones in tumors that are known to be hormone-dependent, such as carcinoma of the breast 23 or prostate, 31 has been shown to correlate significantly with the clinical responsiveness of the tumor to hormone treatment. 17, 18, 23, 31 Clinical observations in meningiomas, such as their higher incidence in women than in men (especially in the presence of obesity or breast carcinoma) and their increased growth rate during pregnancy, suggest that these tumors are also hormone-dependent in vivo . 6 Furthermore

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Cavernous angioma within an olfactory groove meningioma

Olivier Klein, Sébastien Freppel, Jean Auque, and Thierry Civit

S kull base meningiomas and cerebral cavernous angiomas are quite frequently encountered in a neurosurgical practice. The association between these two entities is nevertheless very uncommon and, as far as we know, has never before been reported in the literature. We present a case in which this unusual association was found, and we discuss the propensity of each of these lesions to be revealed by intracranial hemorrhage. Case Report History, Examination, and Neuroimaging Findings. This 60-year-old woman presented to the emergency department

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Platelet-activating factor and edema surrounding meningiomas

Yutaka Hirashima, Nakamasa Hayashi, Osamu Fukuda, Hideki Ito, Shunro Endo, and Akira Takaku

wide spectrum of activity and close metabolic links to the eicosanoids, 2, 18 is produced by a variety of cells, including inflammatory cells such as leukocytes. This factor is a chemoattractant for inflammatory cells and an enhancer of vascular permeability. 2 Treatment with a PAF antagonist results in reduction of edema formation after cerebral infarction 15 and neurological trauma. 5 Therefore, PAF is a candidate factor in the causation of edema surrounding meningiomas. To investigate the role of this factor in such cases, we correlated PAF concentrations

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Tentorial meningioma and painful tic convulsif

Case report

Hidenori Ogasawara, Shuichi Oki, Hiroaki Kohno, Seiichiro Hibino, and Yoko Ito

P osterior fossa tumors (neurinomas, meningiomas, and epidermoids) are likely to cause trigeminal neuralgia and facial spasm. 7, 11, 16 Painful tic convulsif was first described in 1920 by Cushing 3 in those patients displaying a combination of facial pain and ipsilateral hemifacial spasm. Since that time, only a few cases of painful tic convulsif have been reported. To our knowledge, there have been only eight cases of these tumors causing this condition. In these eight patients described in the literature, the tumors directly compressed the fifth and

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Hydroxyurea chemotherapy in the treatment of meningiomas

Herbert B. Newton

Introduction and General Overview Meningiomas are usually slow growing, benign tumors of extraaxial origin that arise from the arachnoidal cap cells associated with the arachnoid villi at the dural venous sinuses, cranial nerve foramina, cribiform plate, and medial middle fossa. 4 , 6 , 9 , 36 Meningiomas are classified by their site of origin within the nervous system, which is most commonly the intracranial cavity. In adults 85 to 90% of tumors occur supratentorially, with 30 to 40% arising along the base of the anterior and middle fossae. 50 The most

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Spontaneous intracranial meningioma bleeding: clinicopathological features and outcome

Róman Boŝnjak, Christopher Derham, Mara Popović, and Janez Ravnik

H emorrhage is a very rare and unusual presentation of benign intracranial tumors 1, 7, 102 except in cases of pituitary adenoma. 101 Meningiomas are benign, slow-growing, and highly vascularized tumors; it is extremely rare that their onset is apoplectiform, mimicking cerebrovascular incidents and thus affecting diagnostic workup, treatment, and outcome. No cases of hemorrhage secondary to meningioma have been reported in the literature by the following authors: Cushing and Eisenhardt, 17 Hoessly and Olivecrona, 34 Jellinger and Slowik, 39 and MacCarty

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Intracranial meningiomas of the first two decades of life

Isabelle M. Germano, Michael S. B. Edwards, Richard L. Davis, and Davide Schiffer

M eningiomas occur predominantly during the fifth decade of life and account for 13.4% to 27.3% of all primary intracranial tumors. 5, 39 Meningiomas of the first two decades of life are distinctly less common, with a corresponding incidence of 1% to 4%, 2–4, 9, 11, 13, 14, 19, 21, 25, 26, 28, 29, 36 and their characteristics relative to those of meningiomas in adults are controversial. Several authors believe that meningiomas in younger patients occur in different locations, have more malignant histological features, and have a worse clinical outcome. 4, 28

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Hormonal manipulation of meningiomas in vitro

Jeffrey J. Olson, David W. Beck, Janet Schlechte, and Pao-Min Loh

I t has been suggested that meningiomas are subject to endocrine influence. 17, 18, 88 This conjecture is based on epidemiological and clinical factors, such as the predominance of these tumors in women, 18, 44, 70 and case reports of exacerbation of meningioma symptoms associated with pregnancy. 5, 17, 83 Investigations resulting from these observations have led to the discovery of estrogen- and progesterone-binding proteins, as well as other steroid hormone-binding proteins in meningiomas. 19, 65, 66, 85 Surgical resection of meningiomas is the treatment

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Papillary meningioma involving the oculomotor nerve in an infant

Case report

Joseph H. Piatt Jr., Gerald A. Campbell, and W. Jerry Oakes

M eningiomas are uncommon tumors in children. In several large series of childhood intracranial tumors, they represented from 0.4% to 6.0% of cases. 3, 9, 11, 21, 28, 30 Mendiratta, et al. , 23 collected 2620 cases of intracranial tumor in the pediatric age group from the literature prior to 1967; only 1.5% of these tumors were meningiomas. Yet this lesion constitutes about 14% of all intracranial neoplasms in adults. 29 There may be qualitative as well as quantitative differences between meningiomas in children and histologically similar lesions in adults

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Lymphoplasmacyte-rich meningioma with clinical resemblance to inflammatory pseudotumor

Report of two cases

Toshiaki Yamaki, Tatsuru Ikeda, Yasuo Sakamoto, Masafumi Ohtaki, and Kazuo Hashi

I nflammatory infiltrates of typical meningiomas are described as being generally sparse and widely scattered, with occasional perivascular cuffing. 22 There have been several reports, however, of meningiomas with such conspicuous lymphocyte and plasma cell infiltration that the meningiomatous component is obscured by inflammatory granulation. 2, 11 The World Health Organization has recently designated these tumors as a lymphoplasmacyte-rich variant of meningioma, with the proviso that meningothelial tissue must be involved in the tumor. 13 Some authors