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Methylation markers of malignant potential in meningiomas

Laboratory investigation

Jaime Vengoechea, Andrew E. Sloan, Yanwen Chen, Xiaowei Guan, Quinn T. Ostrom, Amber Kerstetter, Devan Capella, Mark L. Cohen, Yingli Wolinsky, Karen Devine, Warren Selman, Gene H. Barnett, Ronald E. Warnick, Christopher McPherson, E. Antonio Chiocca, J. Bradley Elder, and Jill S. Barnholtz-Sloan

M eningiomas account for 34% of all CNS tumors, with an estimated incidence of 6.59 per 100,000 in the US. 7 There is some controversy regarding the origin of meningiomas, but they appear to arise from the apex of arachnoid granulations in the meninges. 8 Meningiomas are classified according to the WHO grading system into Grade I, II, or III. Around 80% of meningiomas are benign, WHO Grade I tumors. 23 The prognosis for benign meningiomas is very good, but the 5-year survival for Grade II meningiomas is 79% and that of Grade III tumors is 53%. 9

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Gamma Knife surgery for benign meningioma

Aurelia Kollová, Roman Liščák, Josef Novotný Jr., Vilibald Vladyka, Gabriela Šimonová, and Ladislava Janoušková

M eningiomas are tumors arising from arachnoidal cap cells and represent approximately 20% of all intracranial neoplasms. Ninety to 95% of diagnosed meningiomas are benign (World Health Organization Grade I). Their incidence in the population is reported to be 1 to 6 per 100,000 persons. 10 , 60 Superficially located, these lesions are often considered an ideal target for resection, but their skull base localization represents a complex surgical challenge accompanied by a lot of controversy regarding their treatment. Because of refinements in surgical

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Tuberculoma masquerading as a meningioma

Case report

Konstantin Elisevich and E. Joy Arpin

in intracranial mass lesions of tuberculous origin. The following is a report of such a case, demonstrating geographical, radiological, and clinical features of a meningioma of the anterior frontal fossa. Case Report This 33-year-old Algerian electrical engineer suffered his first seizure in November, 1978, awakening with bilateral tremors of his arms, difficulty in breathing, and transient loss of consciousness. His wife witnessed a grand mal seizure. First Admission . Neurological examination was normal. Initial investigations included a brain scan, which

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Meningiomas of the lateral ventricles

Neuroradiological and surgical considerations in 18 cases

Maurizio Fornari, Mario Savoiardo, Giulio Morello, and Carlo L. Solero

M eningiomas of the lateral ventricles are uncommon tumors. They represent about 2% of intracranial meningiomas, which, in their turn, account for 13% to 18% of all intracranial tumors. 27 Most of the reports dealing with this subject are not recent. We reviewed 18 cases of meningiomas of the lateral ventricles operated on at the Neurological Institute of Milan from 1956 through 1978 (1.5% of the 1175 intracranial meningiomas operated on in that period) with special regard to the neuroradiological diagnosis and the surgical approach. Summary of Cases

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Pseudopsammomatous meningioma with elevated serum carcinoembryonic antigen: a true secretory meningioma

Case report

David N. Louis, Allan J. Hamilton, Raymond A. Sobel, and Robert G. Ojemann

metastatic from primary brain tumors. We report the first case of a primary intracranial tumor with both immunohistochemical evidence of CEA positivity and elevated serum CEA levels. Case Report This 60-year-old right-handed woman was admitted to the Massachusetts General Hospital for removal of a right sphenoid-wing meningioma. She had undergone a laminectomy for cervical disc disease 14 years prior to this admission; 4 hours after that operation she had developed a left hemiparesis which cleared in 5 days. Ten years prior to her present admission, she had

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Spinal meningioma after treatment for Hodgkin disease

Case report

Andrew J. Martin, Christopher J. Hammond, H. Jane Dobbs, Safa Al-Sarraj, and Nicholas W. M. Thomas

) comprise the majority of second malignancies. They are most strongly associated with previous combined radiotherapy and chemotherapy and have continued to develop at increased frequency for many decades. Forms of leukemia also occur, usually in patients who have undergone chemotherapy and within 10 years of treatment. We present, to the best of our knowledge, the first report of a spinal meningioma that seems likely to have been induced by combined-modality treatment for Hodgkin disease. Case Report First Presentation and Examination In 1991, this 26-year

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Repeated subarachnoid hemorrhages from a cervical meningioma

Case report

Giuseppe Scotti, Felice Filizzolo, Giuseppe Scialfa, Donatella Tampieri, and Pietro Versari

R epeated episodes of subarachnoid hemorrhage (SAH) have been reported as presenting symptoms of intracranial meningiomas in a very limited number of patients. 4–7, 11 Even rarer is hemorrhage within spinal meningiomas. 9 Such hemorrhagic episodes are unusual and can occur within the tumor, in the subarachnoid or subdural spaces, or in the brain parenchyma. We are reporting a case in which magnetic resonance imaging (MRI) revealed a small meningioma located between the foramen magnum and C-1, posterior to the cord. The tumor had been responsible for three

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Genomic landscape of intracranial meningiomas

Wenya Linda Bi, Malak Abedalthagafi, Peleg Horowitz, Pankaj K. Agarwalla, Yu Mei, Ayal A. Aizer, Ryan Brewster, Gavin P. Dunn, Ossama Al-Mefty, Brian M. Alexander, Sandro Santagata, Rameen Beroukhim, and Ian F. Dunn

M eningiomas are the most common primary intracranial neoplasms in adults, accounting for 35.8% of all primary CNS tumors and more than 53% of all benign CNS tumors diagnosed in the US. 65 Autopsy and imaging studies suggest an even higher prevalence, affecting almost 3% of women. 98 These lesions are believed to arise from progenitor cells that give rise to both the arachnoid cap cells of the arachnoid layer and fibroblasts that reside in the inner dura mater. 18 , 45 The vast majority of meningiomas are indolent. 36 A small percentage, however

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Vascular ultrastructure in human meningiomas and schwannomas

Don M. Long

-brain barrier to protein had been demonstrated by the use of fluorescein-protein tracers, 8 we discovered open capillary junctions, gaps between capillary endothelial cells, and fenestrated capillary walls. We postulated that these defective capillary walls were the anatomical paths by which the protein-labeled tracers could gain access to the extracellular space within these tumors and that their presence could explain the absence of a blood-brain barrier phenomenon. Meningiomas and schwannomas also have no blood-brain barrier to protein. Both tumors stain brightly with

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Hormonal dependency of cerebral meningiomas

Part 1: Female sex steroid receptors and their significance as specific markers for adjuvant medical therapy

Uwe M. H. Schrell, Eric F. Adams, Rudolf Fahlbusch, Robert Greb, Gustav Jirikowski, Reinhard Prior, and Flavio J. Ramalho-Ortigao

T he concept that the growth of cerebral meningiomas may be under the control of female sex steroids was renewed in 1979 when it was reported that estrogen binding sites were present in the cytosol of meningioma tissue. 11 Since then, many authors have examined the presence of estrogen and progesterone receptors within meningiomas. 3, 5, 9, 10, 17, 23, 26, 29, 30, 33, 38, 40, 42, 44 There is, however, considerable controversy concerning the presence of the cytoplasmic estrogen receptor. Whereas some groups reported measurable amounts of cytoplasmic estrogen