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Gamma Knife surgery–induced meningioma

Report of two cases and review of the literature

Jason Sheehan, Chun PO Yen, and Ladislau Steiner

subsequent MR imaging study performed in 2004 revealed slight growth of this lesion but no significant mass effect or peritumoral edema ( Fig. 2 right ). On neuroimaging, this lesion appears most consistent with a meningioma. Because the mass is asymptomatic, no histopathological testing has been performed. The area of brain tissue in which the lesion appeared received approximately 0.6 Gy during GKS in 1990 and 0.25 Gy in 1995. The patient, who is now 22 years old, will be monitored closely using serial MR imaging to detect any further growth of this lesion. F ig

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Multiple meningiomas: a long-term review

John P. Sheehy and H. Alan Crockard

M ultiple meningiomas were first described by Anfimow and Blumenau 1 in 1889. Heuer and Dandy 12 described successful surgery for this disease in 1916. In 1938, this entity was defined by Cushing and Eisenhardt, 3 who used the term to refer to a condition in which the patient had more than one meningioma and less than a diffusion of them, without signs of neurofibromatosis. Cases are rare, with an accepted incidence of 1% to 2%, although Horrax 13 indicated that they were more common (6.7%). Most reports in the literature have contained only a small

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Multiple meningiomas in a patient with Rubinstein—Taybi syndrome

Case report

Marco J. T. Verstegen, Pepijn Van den Munckhof, Dirk Troost, and Gerrit J. Bouma

of the head. 4 Among the reported tumors in the central nervous system were two oligodendrogliomas, two medullo-blastomas, and two meningiomas. In the present case we report on multiple meningiomas in a patient with RTS. Case Report First Admission This 37-year-old woman with previously diagnosed RTS presented with a progressive bonelike swelling of the forehead. Computerized tomography scanning revealed bifrontal hyperostosis of the skull ( Fig. 1 ), with no other intracranial lesion. A biopsy specimen of the lesion showed an ossifying meningioma. The

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Malignant meningioma: clinical and pathological features

Harvey G. Thomas, Clarisse L. Dolman, and Kenneth Berry

T he line of demarcation between benign and malignant meningiomas is equivocal. Modern methods of diagnosis, such as ultrastructural 4, 25 and tissue culture studies, 20 have not been helpful in differentiating between these two types. Cytogenetics may prove useful in the future, since malignant meningiomas display nonrandom karyotypic aberrations, particularly in chromosome 22. 2, 23, 35 At present, however, one must still rely on clinical and pathologic criteria to establish the diagnosis. A history of rapid recurrence, even after apparently complete

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Radiation-induced cerebral meningioma: a recognizable entity

Abraham B. Rubinstein, Mordechai N. Shalit, Mathias L. Cohen, Uri Zandbank, and Eli Reichenthal

A lthough reports as early as 1916 15 warned against the dangers of ionizing radiation, it remained an acceptable treatment for fungal infections of the scalp during the first half of this century. Albert, et al. , 2 in 1966 reported the late effects of radiation therapy for tinea capitis, and disclosed a higher incidence of tumors of the head and neck. In 1969, Munk, et al. , 17 presented a group of five cases from Israel and pointed out the link between radiation treatment for tinea capitis and the late appearance of intracranial meningiomas. In 1972

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Estrogen-receptor protein in intracranial meningiomas

Mark S. Donnell, Glenn A. Meyer, and William L. Donegan

T he tissue concentration of estrogen-receptor protein has been found to correlate well with the response of breast carcinoma to hormonal therapy. 11, 15 This receptor protein has been found in a number of other benign and malignant tissues including liver, 4 pancreas, 21 uterus, 24 uterine leiomyoma, 5 endometrial carcinoma, 13, 23 ovarian papillary adenocarcinoma, 8 malignant melanoma, 6 and colon carcinoma. 14 The epidemiology and clinical course of some meningiomas suggest that these tumors may be hormonally sensitive and that they may contain

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Stereotactic radiation treatment for benign meningiomas

Andrew E. H. Elia, Helen A. Shih, and Jay S. Loeffler

M eningiomas account for 15 to 25% of all primary brain tumors and have a reported annual incidence between one and 10 per 100,000. 47 Surgery is the preferred treatment for benign meningiomas whenever complete resection can be achieved with reasonable morbidity, resulting in 5-, 10-, and 15-year PFS rates of 93, 80, and 68%, respectively. 31 However, complete resection is not possible in 20 to 30% of presenting patients. 31 , 42 In these cases, subtotal resection has inferior results, with 5-, 10-, and 15-year PFS rates of 63, 45, and 9%, respectively

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Postoperative irradiation for subtotally resected meningiomas

A retrospective analysis of 140 patients treated from 1967 to 1990

Brian J. Goldsmith, William M. Wara, Charles B. Wilson, and David A. Larson

F or intracranial meningioma, total resection is the optimum approach to management as it provides long-term disease-free survival for more than 90% of patients treated. 1, 3, 4, 6, 20, 26 Not all meningiomas can be totally resected without an unacceptable risk of morbidity, however. Attempted total resection of petroclival, parasellar, cavernous sinus, and orbital tumors is often associated with postoperative neurological deficits, particularly cranial nerve palsies. 13, 18, 22 As a consequence, surgeons must choose between aggressive resection (with its

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Necrosis in a meningioma following systemic chemotherapy

Case report

Mark Bernstein, Alfonso Villamil, George Davidson, and Charles Erlichman

T he effects of chemotherapy on meningiomas are not well known because there is a paucity of clinical data. The reasons for this are twofold: meningiomas can usually be effectively treated with surgery and/or radiation therapy, and therefore further adjuvant therapy is seldom required; and, intuitively, one would not expect chemotherapeutic agents to be effective in a slowly growing tumor with a low mitotic index such as meningioma. We report necrosis in a meningioma that produced clinical neurological deterioration in a patient receiving systemic chemotherapy

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Meningiomas induced by high-dose cranial irradiation

Ellen E. Mack and Charles B. Wilson

I n 1953, Mann, et al. , 6 reported the first case of a suspected radiation-induced meningioma in a 4-year-old girl who had received 6500 cGy of irradiation to the orbit for the treatment of an optic nerve glioma. Four years later, she developed a meningioma in the irradiated field; the tumor became recurrent and eventually malignant. A causal relationship between radiation therapy and meningioma formation was first demonstrated in 1974 by Modan, et al. , 7 in a review of the medical records of nearly 11,000 Israelis who had received low doses of scalp