Search Results

You are looking at 41 - 50 of 4,523 items for :

  • Refine by Access: all x
Clear All
Restricted access

Hormonal dependency of cerebral meningiomas

Part 2: In vitro effect of steroids, bromocriptine, and epidermal growth factor on growth of meningiomas

Eric F. Adams, Uwe M. H. Schrell, Rudolf Fahlbusch, and Paul Thierauf

S ome meningiomas cannot be removed totally, due to inaccessible anatomical location and/or invasive characteristics, while others have a recurrent nature, recur in different locations, and require repeated surgical removal. It is desirable to have available an adjuvant medical therapy for these tumors. The development of medical modes of therapy for meningiomas may result from a better understanding of the prognostic factors influencing their growth. There are numerous reports indicating that meningiomas possess receptors for progestogens, androgens

Restricted access

Lymphoplasmacyte-rich meningioma in a child

Case report

Hugues Loiseau, Jean-Michel Pedespan, Anne Vital, Cécile Marchal, Claude Vital, and François Cohadon

V arious types of central nervous system masses can mimic a meningioma. However, it is infrequent that one finds the association of a corticodural mass and blood chemistry abnormalities. This association can be harbored by two conspicuous and rare types of meningiomas, which according to the terminology of the new World Health Organization's histological classification 25 are identified as lymphoplasmacyte-rich (LPR) meningioma and chordoid meningioma. These types of meningiomas are usually accompanied by significant peripheral blood abnormalities that

Restricted access

Incidence and clinicopathological features of meningioma

Martin Rohringer, Garnette R. Sutherland, Deon F. Louw, and Anders A. F. Sima

T he epidemiology of meningioma has been studied in two ways, either as hospital-based or as community-based incidences. 3, 4, 6, 7, 12, 13, 21, 26, 29–31, 34, 38, 41 Community-based studies more accurately define the true incidence of intracranial tumors, since hospital-based studies may be biased by referral patterns. Community-based studies report a variable incidence for symptomatic meningioma ranging from 1.0 to 2.8/100,000. All but one of these studies were performed prior to the introduction of computerized tomography (CT) or magnetic resonance (MR

Restricted access

Abscess formation within a parasagittal meningioma

Case report

Mark B. Eisenberg, Rolando Lopez, and Albert E. Stanek

B ecause of their rich blood supply and proximity to dural venous sinuses, meningiomas are prone to seeding by blood-borne “pathogens.” Most commonly these appear in the form of metastatic carcinoma cells. Numerous cases of metastatic cells within a meningioma have been reported. 1–8, 10–15, 17, 18, 22, 23, 25–27 Bacterial seeding of a meningioma with resultant intratumoral abscess formation has been reported once previously, 24 in a chronically ill patient with reduced immune defenses. Ours is the first report of intratumoral abscess formation within a

Restricted access

Intraspinal familial clear cell meningioma in a mother and child

Case report

Jason A. Heth, Patricia Kirby, and Arnold H. Menezes

M eningiomas are relatively common intracranial and spinal tumors in adults but their occurrence in children is uncommon. Many case reports have documented familial meningioma and current debate centers on whether familial meningiomas are allelic to neurofibromatosis. Clear cell meningioma is a variant that has only recently been described. We present the cases of a 7-year-old girl and her mother who each harbored a familial clear cell meningioma. Case Reports Case 1 This 7-year-old right-handed girl presented with a 4-month history of lower back

Full access

The molecular genetics and tumor pathogenesis of meningiomas and the future directions of meningioma treatments

Winward Choy, Won Kim, Daniel Nagasawa, Stephanie Stramotas, Andrew Yew, Quinton Gopen, Andrew T. Parsa, and Isaac Yang

M eningiomas are the second most common adult neoplasm of the CNS, and they are mostly benign, slow-growing tumors originating from the arachnoidal cap cells. 97 The annual incidence of meningiomas is 2.3 per 100,000, increases with age, and peaks in the 7th decade of life. 97 , 98 Overall incidence is greater in females with a 2:1 ratio, yet higher grade meningiomas are more frequent in males. 36 , 67 Deletions of the neurofibromatosis Type 2 (NF2) gene, ionizing radiation, and head trauma are associated with an increased risk, while the role of sex

Restricted access

Estrogen receptor immunoreactivity in meningiomas

Comparison with the binding activity of estrogen, progesterone, and androgen receptors

Klaus-Peter Lesch and Silke Gross

E pidemiological and clinical data indicate a steroid-hormone sensitivity of meningiomas. 2, 18, 22 Meningioma is the only relatively common intracranial and intraspinal neoplasm with a higher incidence among females: 65% of intracranial and 80% of intraspinal meningiomas are found in women. Cushing and Eisenhardt 3 were the first to describe a correlation between pregnancy and the rapid increase of neurological symptoms in patients with meningiomas. Other authors 2, 18 have confirmed that meningiomas increase in size only marginally, and clinical

Restricted access

Pediatric spinal clear cell meningioma

Case report

Chaim B. Colen, Mahmoud Rayes, Jamal McClendon Jr., Raja Rabah, and Steven D. Ham

S pinal meningiomas comprise almost 46% of all primary spinal cord tumors, are found predominantly in females, are largely intradural-extramedullary, and occur mostly in the thoracic region. 6 Meningiomas of the lumbosacral region are relatively uncommon. Clear cell meningioma is a rare variant of meningioma; it accounts for 0.2% of all meningiomas, is more common in younger patients, arises more often in spinal or cerebellopontine locations, and shows a more aggressive nature with a higher recurrence rate. Although CCM is considered a benign tumor (WHO

Restricted access

Intraparenchymal meningioma originating from underlying meningioangiomatosis

Case report and review of the literature

Melike Mut, Figen Söylemezoğlu, M. Murat Firat, and Selçuk Palaoğlu

M eningioangiomatosis is a rare meningovascular lesion characterized by proliferation of meningothelial and fibroblast-like cells encircling small cortical vessels. The histogenesis of these sporadic lesions is unclear. They may present with seizures and persistent headache, 10 and multiple meningioangiomatosis is generally associated with NF2. Unusual associations of meningioma and meningioangiomatosis are reviewed. 1, 2, 5, 14, 22 All of the reported cases are extraaxial meningiomas with meningioangiomatosis in the underlying cortex ( Table 1 ). TABLE 1

Restricted access

Stereotactic radiosurgery for convexity meningiomas

Clinical article

Douglas Kondziolka, Ricky Madhok, L. Dade Lunsford, David Mathieu, Juan J. Martin, Ajay Niranjan, and John C. Flickinger

“A discussion of the convexity tumors that lie free of attachment to a major sinus had been postponed to the end of this study on the assumption that being so well known and so numerous they would be less interesting than the other groups and could be dismissed with brevity.” C ushing and E isenhardt , 1938. 4 Of all intracranial meningiomas, those located along the cerebral convexities are assumed to be associated with the lowest risk for requiring resection. Craniotomy and removal of a meningioma and its dural base is the preferred choice of