✓ The author provides a brief history of the genesis of organized neurosurgery and, in particular, the formation and evolution of the American Association of Neurological Surgeons. The legacy of neurosurgery is noted and the author discusses the present and future practice of neurosurgery.
2000 Presidential address
Martin H. Weiss
Martin H. Weiss and Frank E. Nulsen
Martin H. Weiss and John A. Jane
Martin H. Weiss and Uros Roessmann
✓ Hydrocephalic animals were given an intraventricular infusion of radioactive colloidal gold and then sacrificed up to 7 weeks after infusion. Histological evaluation revealed progression from a marked hemorrhagic necrosis of choroid plexus vessels and stroma to eventual replacement by fibrous connective tissue, sclerosis, and fibrinous degeneration of stromal vessels. Particulate colloid was found engulfed in perivascular spaces in the subependymal periventricular tissues, but there was no evidence of vascular damage, gliosis, or demyelination. These findings may play a role in decreasing cerebrospinal fluid production.
Martin H. Weiss
Laboratory and clinical study
Martin H. Weiss, Theodore Kurze, and Frank E. Nulsen
✓ By ventriculocisternal perfusion, a series of newer antibiotics were circulated through the central nervous system to ascertain the potential toxicity of these drugs to the nervous parenchyma. Ampicillin, carbenicillin, gentamycin sulfate, and polymyxin B sulfate appear to be well tolerated whereas cephalexin monohydrate and penicillin G caused a repeated pattern of significant CSF pleocytosis, histological evidence of periventricular perivascular infiltrates, and evidence of clinical toxicity. A regime for treatment of central nervous system infections is presented, derived from the data presented above. Preliminary experience in a clinical series appears to support this program.
Martin H. Weiss, Harold F. Young, and Dee E. McFarland
William T. Couldwell, Parakrama T. Chandrasoma, and Martin H. Weiss
✓ A case of prostatic carcinoma metastasis to the pituitary gland is reported. The presentation and rarity of such a lesion is addressed. The literature review yielded only isolated case reports of symptomatic brain metastases unassociated with bone disease from adenocarcinoma of the prostate. The management options of such a lesion are discussed.
Adrian L. Rabinowicz, Martin H. Weiss, and Christopher M. DeGiorgio
✓ The authors report the case of an individual who developed compulsive polydipsia following resection of a left sphenoidal ridge meningioma. The episodic, stereotyped nature of his symptoms, response to treatment, and electroencephalographic and magnetic resonance imaging findings are all highly consistent with temporal lobe-onset epilepsy. The pathophysiology of this underrecognized phenomenon is discussed.
Jane C. S. Perrin, Martin H. Weiss, and David Yashon
✓ A family with craniofacial dysostosis affecting a father and his monozygotic twin sons is described. The father had no surgery until linear craniectomy when 3 years old; he is of normal intelligence but legally blind. Prophylactic coronal craniectomy and orbital decompression were done on the twins. One had an uncomplicated course and is developing normally. The other developed neonatal meningitis and ventriculitis with secondary hydrocephalus, plus poor vision and retarded development.