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Beagle puppy model of intraventricular hemorrhage

Effect of indomethacin on local cerebral glucose utilization

Laura R. Ment, William B. Stewart, Charles C. Duncan, David T. Scott, and Richard Lambrecht

I ntraventricular hemorrhage (IVH), or hemorrhage into the germinal matrix tissues (GMH) of the developing brain, 20 is a major neurological problem of preterm neonates, 60 and has been found in over 40% of all preterm neonates with a birth weight of 1500 gm or less. 11, 43 Thought to be secondary to alterations in cerebral blood flow (CBF) to the preterm cerebrum, 4, 29, 36 IVH has also been associated with changes in cerebral metabolism, 30, 59 and both the alterations in CBF and the metabolic changes may contribute to the later neurodevelopmental