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Alejandro M. Spiotta, Michael F. Stiefel, Vicente H. Gracias, Alicia M. Garuffe, W. Andrew Kofke, Eileen Maloney-Wilensky, Andrea B. Troxel, Joshua M. Levine, and Peter D. Le Roux

randomised controlled trial . Lancet Neurol 6 : 29 – 38 , 2007 53 Tolias CM , Reinert M , Seiler R , Gilman C , Scharf A , Bullock MR : Normobaric hyperoxia—induced improvement in cerebral metabolism and reduction in intracranial pressure in patients with severe head injury: a prospective historical cohort-matched study . J Neurosurg 101 : 435 – 444 , 2004 54 Valadka AB , Gopinath SP , Contant CF , Uzura M , Robertson CS : Relationship of brain tissue PO2 to outcome after severe head injury . Crit Care Med 26 : 1576 – 1581