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Michael F. Stiefel, Alejandro Spiotta, Vincent H. Gracias, Alicia M. Garuffe, Oscar Guillamondegui, Eileen Maloney-Wilensky, Stephanie Bloom, M. Sean Grady, and Peter D. LeRoux

CPP and brain O 2 is not observed in every patient, in large part because autoregulation frequently is disturbed. 39 Results from recent studies have also demonstrated that an increase in brain tissue PO 2 is associated with improved cerebral metabolism. 32, 45 Together these data indicate that it is reasonable to assume that the use of a brain tissue PO 2 monitor and efforts to increase brain O 2 delivery may improve TBI outcome. Brain Tissue PO 2 —Guided Therapy and Outcome Results of this study demonstrate that brain tissue PO 2 —guided treatment is