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Masayuki Matsuda, John Stirling Meyer, Vinod D. Deshmukh, and Yukio Tagashira

anticholinesterase, neostigmine, enhances cerebral vasodilatory response to CO 2 inhalation and reduces cerebral autoregulatory vasoconstriction during increases of cerebral perfusion pressure (CPP). 1 The present experiments were designed to study the effects of Ach on CBF and cerebral metabolism when administered by different routes, namely, by intravertebral, arterial, intracarotid, or intravenous infusion. Any effect was also measured on the cerebral vascular response to CO 2 . Materials and Methods Seventeen baboons (Papio anubis) weighing 3.4 to 6.2 kg were

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Yukio Tagashira, Masayuki Matsuda, Kenneth M. A. Welch, Eva Chabi, and John S. Meyer

. On the other hand, the CBF increase produced by cyclic AMP was accompanied by coincidental increase of CMRO 2 and CMRGl. Since CBF may increase secondary to stimulation of cerebral metabolism, 9 any additional primary effect of cyclic AMP on the cerebral vasculature cannot therefore be directly established. Doses of cyclic AMP employed in the current experiments were high (up to 300-fold) compared to physiological circulating levels in the baboon (20 to 40 picomole/ml). We do not believe that this alters the relevance of our observations since cyclic AMP

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Masayuki Matsuda, Shunichi Yoneda, Hiroshi Gotoh, Jyoji Handa, and Hajime Handa

I t is well known that cerebral blood vessels are innervated by both adrenergic and cholinergic nerve fibers. 2, 7–9, 14, 25–27 The functional role of cholinergic nerves on cerebral circulation, however, remains obscure compared with that of adrenergic nerves. Stimulation of cholinergic nerves by acetylcholine dilates cerebral blood vessels 18, 35 and increases cerebral blood flow (CBF). 4, 20, 28, 33 Acetylcholine perfusing the brain-stem neurons increases cerebral metabolism and CBF. 20 It is reported, however, that atropine, a postganglionic cholinergic

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Central cholinergic control of cerebral blood flow in the baboon

Effect of cholinesterase inhibition with neostigmine on autoregulation and CO2 responsiveness

Minoru Aoyagi, John Stirling Meyer, Vinod D. Deshmukh, Erwin O. Ott, Yukio Tagashira, Yasuo Kawamura, Masayuki Matsuda, Amrit N. Achari, and Anthony N. C. Chee

intracarotid infusion. The drug was infused intravertebrally in a dose of 12.5 µg/kg of body weight, or 25 µg/kg of body weight was infused into the carotid artery. The measurements of cerebral autoregulatory responsiveness and vasomotor reactivity to CO 2 as well as cerebral metabolism were carried out after repeated steady states in a serial manner before and after neostigmine administration. In order to compare the effect of intravertebral infusion to that of intracarotid infusion, the animals were divided into two groups comprising six animals for each arterial route of