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Time course for autoregulation recovery following severe traumatic brain injury

Clinical article

Gill E. Sviri, Rune Aaslid, Colleen M. Douville, Anne Moore, and David W. Newell

  diffuse 25   1 or 2 18   3 or 4 7 mechanism of injury  MVA 19  auto pedestrian 7  fall 7  assault 3 ICP  controlled 23  elevated 13 6-mo outcome (GOS)  favorable 16  unfavorable 20 * EDH = epidural hematoma; ICH = intracerebral hematoma; MVA = motor vehicle accident; SDH = subdural hematoma. The severity of neurological impairment on admission was assessed using the GCS 13 at the end of the resuscitation and initial surgeries. The type of brain injury on admission was assessed on CT scans

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Cerebral autoregulation following minor head injury

Elisabeth C. Jünger, David W. Newell, Gerald A. Grant, Anthony M. Avellino, Saadi Ghatan, Colleen M. Douville, Arthur M. Lam, Rune Aaslid, and H. Richard Winn

hemorrhage; SDH = subdural hematoma. TABLE 2 Demographics in normal volunteers and patients with minor head injury Parameter Volunteers Head-Injured Patients p Value no. of participants 29 29 sex  male 18 23  female 11 6 age (yrs) 38 ± 16 38 ± 16 0.92 GCS score 15 14.7 ± 0.5 MABP at rest 85 ± 10 89 ± 18 0.33 heart rate at rest * 66 ± 9 78 ± 15 0.0005 lt CBF velocity 61 ± 14 61 ± 16 0.96 rt CBF velocity 60 ± 13