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The relationship of blood flow velocity fluctuations to intracranial pressure B waves

David W. Newell, Rune Aaslid, Renate Stooss, and Hans J. Reulen

arteries is responsible. 4 Others have implicated an intrinsic brain-stem pacemaker that alters other physiological parameters as well as CBF at a regular frequency. 10, 14 The finding of synchronous fluctuations of blood flow in both MCA's suggests the presence of a central control mechanism or a synchronizing mechanism. It was commonly observed ( Figs. 3 and 4 ) that the velocity wave would begin before the change in ICP took place and thus was independent of any change in transmural or cerebral perfusion pressure. The inverse relationship found between ICP and

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Cerebral autoregulation following minor head injury

Elisabeth C. Jünger, David W. Newell, Gerald A. Grant, Anthony M. Avellino, Saadi Ghatan, Colleen M. Douville, Arthur M. Lam, Rune Aaslid, and H. Richard Winn

T he cerebral circulation has a capacity to maintain blood flow at a relatively constant level during changes in blood pressure. This phenomenon, known as cerebral autoregulation, is usually observed between a mean arterial blood pressure (MABP) of approximately 50 and 150 mm Hg. 14, 26 Cerebral autoregulation can be impaired or absent following severe closed head injury. 4–6, 8, 9, 21, 22, 25, 26 Impairments in autoregulation may contribute by several mechanisms to secondary neuronal injury following head injury. Lowered cerebral perfusion pressure (CPP