Cystic choroid plexus papilloma in the cavum septum pellucidum

Case report

Restricted access

A choroid plexus papilloma is a rare CNS neoplasm arising from the neuroepithelial lining of the choroid plexus. A third ventricular location of a choroid plexus papilloma is rare compared with the more common sites in the lateral and fourth ventricles. Cystic choroid plexus papilloma represents an infrequent subtype that may present diagnostic ambiguity. The authors present a case of cystic choroid plexus papilloma within a cavum septum pellucidum that radiographically mimicked neurocysticercosis.

Article Information

Address correspondence to: Stephen P. Kalhorn, M.D., Department of Neurosurgery, NYU Langone Medical Center, 462 First Avenue, Bellevue Hospital, Room 7S4, New York, New York 10016. email:

© AANS, except where prohibited by US copyright law.



  • View in gallery

    Preoperative T1-weighted MR image with Gd enhancement showing cystic structure within cavum septum pellucidum with an associated enhancing nodule.

  • View in gallery

    Postoperative T1-weighted MR image with Gd enhancement showing resection of previously observed lesion.

  • View in gallery

    Comparison of photomicrographs from our case (upper) and a normal choroid plexus (lower). Upper: Image demonstrating a cystic structure with a fibrous nodule and dilated, thin-walled vascular channels. The inner lining of a cyst shows complex papillary projections with morphological features, and an immunohistochemical profile consistent with choroid plexus papilloma. Lower: Image of a normal choroid plexus from an unrelated autopsy case provided for comparison. This sample demonstrates low cuboidal, uniform epithelium without crowding, overlapping, or atypia of the nuclei. There are “cobblestoned” or “hobnailed” surfaces. H & E, original magnification × 4.

  • View in gallery

    Photomicrograph of the choroid plexus papilloma in this case showing delicate fibrovascular connective tissue fronds covered by columnar epithelium, with disorganization, crowding, overlapping, and atypia of the nuclei. There are increased nuclear-to-cytoplasmic ratios and flat, rather than “cobblestoned,” surfaces. H & E, original magnification × 20.



Aguzzi ABrandner SPaulus WChoroid plexus tumours. Kleihues PCavenee WK: Pathology and Genetics: Tumours of the Nervous System LyonIARC Press2000. 8486


Burger PCScheithauer BW: Tumors of the central nervous system. AFIP Atlas of Tumor Pathology Series 4 Washington, DCAmerican Registry of Pathology2007. 177187


Burger PCScheithauer BWVogel SF: Surgical Pathology of the Nervous System and Its Coverings ed 4PhiladelphiaChurchill Livingstone2002. 258264


Carson BSWeingart JDGuarnieri MFisher PG: Third ventricular choroid plexus papilloma with psychosis. Case report. J Neurosurg 87:1031051997


Emami-Naeini PNejat FEl Khashab M: Cystic choroid plexus papilloma with multiple mural nodules in an infant. Childs Nerv Syst 24:6296312008


García-Valtuille RAbascal FGarcía-Valtuille AIPinto JICerezal LSanz F: Adult choroid plexus papilloma of the posterior fossa mimicking a hemangioblastoma. Case report. J Neurosurg 92:8708722000


Gradin WCTaylon CFruin AH: Choroid plexus papilloma of the third ventricle: case report and review of the literature. Neurosurgery 12:2172201983


Krishnan SBrown PDScheithauer BWEbersold MJHammack JEBuckner JC: Choroid plexus papillomas: a single institutional experience. J Neurooncol 68:49552004


Miyagi YNatori YSuzuki SOIwaki TMorioka TArimura K: Purely cystic form of choroid plexus papilloma with acute hydrocephalus in an infant. Case report. J Neurosurg 105:6 Suppl4804842006


Osborn AGPreece MT: Intracranial cysts: radiologic-pathologic correlation and imaging approach. Radiology 239:6506642006


Patanakar TPrasad SMukherji SKArmao D: Cystic variant of choroid plexus papilloma. Clin Imaging 24:1301312000


Perälä JSuvisaari JSaarni SIKuoppasalmi KIsometsä EPirkola S: Lifetime prevalence of psychotic and bipolar I disorders in a general population. Arch Gen Psychiatry 64:19282007


Pollack IFSchor NFMartinez AJTowbin R: Bobble-head doll syndrome and drop attacks in a child with a cystic choroid plexus papilloma of the third ventricle. Case report. J Neurosurg 83:7297321995


Rickert CHPaulus W: Tumors of the choroid plexus. Microsc Res Tech 52:1041112001


Suh DYMapstone T: Pediatric supratentorial intraventricular tumors. Neurosurg Focus 10:6E42001


Valencak JDietrich WRaderer MDieckmann KPrayer DHainfellner J: Evidence of the therapeutic efficacy of CCNU in recurrent choroid plexus papilloma. J Neurooncol 49:2632682000


Wegener RRummel JSchmidt W: Sudden unexpected death in papilloma of the choroid plexus of rare location. Z Rechtsmed 84:1451471980




All Time Past Year Past 30 Days
Abstract Views 27 27 23
Full Text Views 29 29 16
PDF Downloads 63 63 27
EPUB Downloads 0 0 0


Google Scholar