Transplacental transmission of metastatic melanoma to the posterior fossa

Case report

Eric R. Trumble M.D. 1 , Ryan M. Smith M.B.A. 1 , Gary Pearl M.D., Ph.D. 1 , and Judith Wall M.D. 1
View More View Less
  • 1 Neurosurgeons for Kids, and Departments of Pathology and Pediatric Hematology/Oncology, Arnold Palmer Hospital for Children and Women, Orlando, Florida
Restricted access

Purchase Now

USD  $45.00

JNS + Pediatrics - 1 year subscription bundle (Individuals Only)

USD  $505.00

JNS + Pediatrics + Spine - 1 year subscription bundle (Individuals Only)

USD  $600.00
Print or Print + Online

✓The authors describe the first documented case of transplacental transmission of metastatic melanoma to the neuraxis. The patient was a 7-month-old boy who presented with signs and symptoms of elevated intracranial pressure. Magnetic resonance imaging revealed an inhomogeneously enhancing posterior fossa mass measuring 5 × 5 × 6 cm and filling the fourth ventricle. A posterior fossa craniotomy was performed. Pathological studies confirmed the presence of a metastatic melanoma that was pathologically identical to that of his mother. The boy received aggressive chemotherapy and underwent an additional resection. He also required a ventriculoperitoneal shunt for treatment of his hydrocephalus. He lived longer than any other patient with transplacental transmission of metastatic melanoma but ultimately died of the disease, 18 months after his initial presentation.

JNS + Pediatrics - 1 year subscription bundle (Individuals Only)

USD  $505.00

JNS + Pediatrics + Spine - 1 year subscription bundle (Individuals Only)

USD  $600.00

Contributor Notes

Address reprint requests to: Eric R Trumble, M.D., 22 Lake Beauty Drive, Suite 204, Orlando, Florida 32806. email: etrumble@neurosurgeons4kids.com.
  • 1.

    Altman JF, , Lowe L, , Redman B, , Esper P, , Schwartz JL, & Johnson TM, et al: Placental metastasis of maternal melanoma. J Am Acad Dermatol 49:11501154, 2003 Altman JF, Lowe L, Redman B, Esper P, Schwartz JL, Johnson TM, et al: Placental metastasis of maternal melanoma. J Am Acad Dermatol 49:1150–1154, 2003

    • Search Google Scholar
    • Export Citation
  • 2.

    Anderson JF, , Kent S, & Machin GA: Maternal malignant melanoma with placental metastasis: a case report with literature review. Pediatr Pathol 9:3542, 1989 Anderson JF, Kent S, Machin GA: Maternal malignant melanoma with placental metastasis: a case report with literature review. Pediatr Pathol 9:35–42, 1989

    • Search Google Scholar
    • Export Citation
  • 3.

    Aronsson S: A case of transplacental tumor metastasis. Acta Paediatr 52:123124, 1963 (Abstract) Aronsson S: A case of transplacental tumor metastasis. Acta Paediatr 52:123–124, 1963 (Abstract)

    • Search Google Scholar
    • Export Citation
  • 4.

    Bafaloukos D, , Tsoutsos D, , Fountzilas G, , Linardou H, , Christodoulou C, & Kalofonos HP, et al: The effect of temozolomidebased chemotherapy in patients with cerebral metastases from melanoma. Melanoma Res 14:289294, 2004 Bafaloukos D, Tsoutsos D, Fountzilas G, Linardou H, Christodoulou C, Kalofonos HP, et al: The effect of temozolomidebased chemotherapy in patients with cerebral metastases from melanoma. Melanoma Res 14:289–294, 2004

    • Search Google Scholar
    • Export Citation
  • 5.

    Brodsky I, , Baren M, , Kahn SB, , Lewis G Jr, & Tellem M: Metastatic malignant melanoma from mother to fetus. Cancer 18:10481054, 1965 Brodsky I, Baren M, Kahn SB, Lewis G Jr, Tellem M: Metastatic malignant melanoma from mother to fetus. Cancer 18:1048–1054, 1965

    • Search Google Scholar
    • Export Citation
  • 6.

    Cavell B: Transplacental metastasis of malignant melanoma. Report of a case. Acta Paediatr (Suppl 1) 46:3740, 1963 Cavell B: Transplacental metastasis of malignant melanoma. Report of a case. Acta Paediatr (Suppl 1) 46:37–40, 1963

    • Search Google Scholar
    • Export Citation
  • 7.

    Dargeon HW, , Eversole JW, & Del Duca V: Malignant melanoma in an infant. Cancer 3:229306, 1950 Dargeon HW, Eversole JW, Del Duca V: Malignant melanoma in an infant. Cancer 3:229–306, 1950

    • Search Google Scholar
    • Export Citation
  • 8.

    Driscoll MS, , Grin-Jorgensen CM, & Grant-Kels JM: Does pregnancy influence the prognosis of malignant melanoma? J Am Acad Dermatol 29:619630, 1993 Driscoll MS, Grin-Jorgensen CM, Grant-Kels JM: Does pregnancy influence the prognosis of malignant melanoma? J Am Acad Dermatol 29:619–630, 1993

    • Search Google Scholar
    • Export Citation
  • 9.

    Duncan LM, , Travers RL, , Koerner FC, , Mihm MC Jr, & Sober AJ: Estrogen and progesterone receptor analysis in pregnancy-associated melanoma: absence of immunohistochemically detectable hormone receptors. Hum Pathol 25:3641, 1994 Duncan LM, Travers RL, Koerner FC, Mihm MC Jr, Sober AJ: Estrogen and progesterone receptor analysis in pregnancy-associated melanoma: absence of immunohistochemically detectable hormone receptors. Hum Pathol 25:36–41, 1994

    • Search Google Scholar
    • Export Citation
  • 10.

    Ferreira CM, , Maceira JM, & Coelho JM: Melanoma and pregnancy with placental metastases. Report of a case. Am J Dermatopathol 20:403407, 1998 Ferreira CM, Maceira JM, Coelho JM: Melanoma and pregnancy with placental metastases. Report of a case. Am J Dermatopathol 20:403–407, 1998

    • Search Google Scholar
    • Export Citation
  • 11.

    Gibbs P, , Moore A, , Robinson W, , Walsh P, , Golitz L, & Gonzalez R: Pediatric melanoma: are recent advances in the management of adult melanoma relevant to the pediatric population. J Pediatr Hematol Oncol 22:428432, 2000 Gibbs P, Moore A, Robinson W, Walsh P, Golitz L, Gonzalez R: Pediatric melanoma: are recent advances in the management of adult melanoma relevant to the pediatric population. J Pediatr Hematol Oncol 22:428–432, 2000

    • Search Google Scholar
    • Export Citation
  • 12.

    Gillis H II, , Mortel R, & McGavran MH: Maternal malignant melanoma metastatic to the products of conception. Report of a case. Gynecol Oncol 4:3842, 1976 Gillis H II, Mortel R, McGavran MH: Maternal malignant melanoma metastatic to the products of conception. Report of a case. Gynecol Oncol 4:38–42, 1976

    • Search Google Scholar
    • Export Citation
  • 13.

    Gottron H, & Gertler W: Zur frage des übertritts van melanogen von der mutter auf den säugling über die muttermilch. Arch Dermatol Syphilis 181:9198, 1940 Gottron H, Gertler W: Zur frage des übertritts van melanogen von der mutter auf den säugling über die muttermilch. Arch Dermatol Syphilis 181:91–98, 1940

    • Search Google Scholar
    • Export Citation
  • 14.

    Grin CM, , Driscoll MS, & Grant-Kels JM: Pregnancy and the prognosis of malignant melanoma. Semin Oncol 23:734736, 1996 Grin CM, Driscoll MS, Grant-Kels JM: Pregnancy and the prognosis of malignant melanoma. Semin Oncol 23:734–736, 1996

    • Search Google Scholar
    • Export Citation
  • 15.

    Holland E: A case of transplacental metastasis of malignant melanoma from mother to foetus. J Obstet Gynaecol Br Emp 56:529536, 1949 Holland E: A case of transplacental metastasis of malignant melanoma from mother to foetus. J Obstet Gynaecol Br Emp 56:529–536, 1949

    • Search Google Scholar
    • Export Citation
  • 16.

    MacKie RM, , Bufalino R, , Morabito A, , Sutherland C, & Cascinelli N: Lack of effect of pregnancy on outcome of melanoma. For the World Health Organisation Melanoma Programme. Lancet 337:653655, 1991 MacKie RM, Bufalino R, Morabito A, Sutherland C, Cascinelli N: Lack of effect of pregnancy on outcome of melanoma. For the World Health Organisation Melanoma Programme. Lancet 337:653–655, 1991

    • Search Google Scholar
    • Export Citation
  • 17.

    Meier S, , Baumert BG, , Maier T, , Wellis G, , Burg G, & Seifert B, et al: Survival and prognostic factors in patients with brain metastases from malignant melanoma. Onkologie 27:145149, 2004 Meier S, Baumert BG, Maier T, Wellis G, Burg G, Seifert B, et al: Survival and prognostic factors in patients with brain metastases from malignant melanoma. Onkologie 27:145–149, 2004

    • Search Google Scholar
    • Export Citation
  • 18.

    Potter JF, & Schoeneman M: Metastasis of maternal cancer to the placenta and fetus. Cancer 25:380388, 1970 Potter JF, Schoeneman M: Metastasis of maternal cancer to the placenta and fetus. Cancer 25:380–388, 1970

    • Search Google Scholar
    • Export Citation
  • 19.

    Radbill AE, , Fiveash JF, , Falkenberg ET, , Guthrie BL, , Young PE, & Meleth S, et al: Initial treatment of melanoma brain metastases using gamma knife radiosurgery: an evaluation of efficacy and toxicity. Cancer 101:825833, 2004 Radbill AE, Fiveash JF, Falkenberg ET, Guthrie BL, Young PE, Meleth S, et al: Initial treatment of melanoma brain metastases using gamma knife radiosurgery: an evaluation of efficacy and toxicity. Cancer 101:825–833, 2004

    • Search Google Scholar
    • Export Citation
  • 20.

    Reintgen DS, , McCarty KS Jr, , Vollmer R, , Cox E, & Seigler HF: Malignant melanoma and pregnancy. Cancer 55:13401344, 1985 Reintgen DS, McCarty KS Jr, Vollmer R, Cox E, Seigler HF: Malignant melanoma and pregnancy. Cancer 55:1340–1344, 1985

    • Search Google Scholar
    • Export Citation
  • 21.

    Tolar J, & Neglia JP: Transplacental and other routes of cancer transmission between individuals. J Pediatr Hematol Oncol 25:430434, 2003 Tolar J, Neglia JP: Transplacental and other routes of cancer transmission between individuals. J Pediatr Hematol Oncol 25:430–434, 2003

    • Search Google Scholar
    • Export Citation
  • 22.

    Travers RL, , Sober AJ, , Berwick M, , Mihm MC Jr, , Barnhill RL, & Duncan LM: Increased thickness of pregnancy-associated melanoma. Br J Dermatol 132:876883, 1995 Travers RL, Sober AJ, Berwick M, Mihm MC Jr, Barnhill RL, Duncan LM: Increased thickness of pregnancy-associated melanoma. Br J Dermatol 132:876–883, 1995

    • Search Google Scholar
    • Export Citation
  • 23.

    Weber FP, , Schwarz E, & Hellenschmied R: Spontaneous inoculation of melanotic sarcoma from mother to foetus. Report of a case. Br Med J 1:537539, 1930 Weber FP, Schwarz E, Hellenschmied R: Spontaneous inoculation of melanotic sarcoma from mother to foetus. Report of a case. Br Med J 1:537–539, 1930

    • Search Google Scholar
    • Export Citation

Metrics

All Time Past Year Past 30 Days
Abstract Views 214 86 35
Full Text Views 39 3 2
PDF Downloads 99 3 3
EPUB Downloads 0 0 0