Neonatal posthemorrhagic hydrocephalus from prematurity: pathophysiology and current treatment concepts

A review

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Object

Preterm infants are at risk for perinatal complications, including germinal matrix–intraventricular hemorrhage (IVH) and subsequent posthemorrhagic hydrocephalus (PHH). This review summarizes the current understanding of the epidemiology, pathophysiology, management, and outcomes of IVH and PHH in preterm infants.

Methods

The MEDLINE database was systematically searched using terms related to IVH, PHH, and relevant neurosurgical procedures to identify publications in the English medical literature. To complement information from the systematic search, pertinent articles were selected from the references of articles identified in the initial search.

Results

This review summarizes the current knowledge regarding the epidemiology and pathophysiology of IVH and PHH, primarily using evidence-based studies. Advances in obstetrics and neonatology over the past few decades have contributed to a marked improvement in the survival of preterm infants, and neurological morbidity is also starting to decrease. The incidence of IVH is declining, and the incidence of PHH will likely follow. Currently, approximately 15% of preterm infants who suffer severe IVH will require permanent CSF diversion. The clinical presentation and surgical management of symptomatic PHH with temporary ventricular reservoirs (ventricular access devices) and ventriculosubgaleal shunts and permanent ventriculoperitoneal shunts are discussed. Preterm infants who develop PHH that requires surgical treatment remain at high risk for other related neurological problems, including cerebral palsy, epilepsy, and cognitive and behavioral delay. This review highlights numerous opportunities for further study to improve the care of these children.

Conclusions

A better grasp of the pathophysiology of IVH is beginning to impact the incidence of IVH and PHH. Neonatologists conduct rigorous Class I and II studies to advance the outcomes of preterm infants. The need for well-designed multicenter trials is essential because of the declining incidence of IVH and PHH, variations in referral patterns, and neonatal ICU and neurosurgical management. Well-designed multicenter trials will eventually produce evidence to enable neurosurgeons to provide their smallest, most vulnerable patients with the best practices to minimize perioperative complications and permanent shunt dependence, and most importantly, optimize long-term neurodevelopmental outcomes.

Abbreviations used in this paper:AHW = anterior horn width; cPVL = cystic periventricular leukomalacia; EGA = estimated gestational age; EPO = erythropoietin; ETV = endoscopic third ventriculostomy; ICP = intracranial pressure; IL = interleukin; IVH = germinal matrix–intraventricular hemorrhage; LP = lumbar puncture; MDI = Bayley Mental Developmental Index; NICU = neonatal ICU; paCO2 = partial pressure of CO2; PDI = Bayley Psychomotor Developmental Index; PHH = posthemorrhagic hydrocephalus; PHVD = posthemorrhagic ventricular dilation; PVHI = periventricular hemorrhagic infarction; PVL = periventricular leukomalacia; rEPO = recombinant EPO; rtPA = recombinant tissue plasminogen activator; TGF = transforming growth factor; VP = ventriculoperitoneal; VSG = ventriculosubgaleal.
Article Information

Contributor Notes

Current address for Dr. Robinson: Department of Neurosurgery, Children's Hospital Boston, Massachusetts.Address correspondence to: Shenandoah Robinson, M.D., Department of Neurosurgery, Children's Hospital Boston, Hunnewell 2, 300 Longwood Avenue, Boston, Massachusetts 02115. email: shenandoah.robinson@childrens.harvard.edu.Please include this information when citing this paper: DOI: 10.3171/2011.12.PEDS11136.

© AANS, except where prohibited by US copyright law.

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References
  • 1

    Adams-Chapman IStoll BJ: Neonatal infection and long-term neurodevelopmental outcome in the preterm infant. Curr Opin Infect Dis 19:2902972006

    • Search Google Scholar
    • Export Citation
  • 2

    Aquilina KHobbs CTucker AWhitelaw AThoresen M: Do drugs that block transforming growth factor beta reduce posthaemorrhagic ventricular dilatation in a neonatal rat model?. Acta Paediatr 97:118111862008

    • Search Google Scholar
    • Export Citation
  • 3

    Baer VLLambert DKHenry ESnow GLButler AChristensen RD: Among very-low-birth-weight neonates is red blood cell transfusion an independent risk factor for subsequently developing a severe intraventricular hemorrhage?. Transfusion 51:117011782011

    • Search Google Scholar
    • Export Citation
  • 4

    Barnes CMMcElrath TFFolkman JHansen AR: Correlation of 2-methoxyestradiol levels in cord blood and complications of prematurity. Pediatr Res 67:5455502010

    • Search Google Scholar
    • Export Citation
  • 5

    Barnette ARMyers BJBerg CSInder TE: Sodium intake and intraventricular hemorrhage in the preterm infant. Ann Neurol 67:8178232010

    • Search Google Scholar
    • Export Citation
  • 6

    Barrington KJFiner N: Inhaled nitric oxide for respiratory failure in preterm infants. Cochrane Database Syst Rev 12:CD0005092010

  • 7

    Bass JKBass WTGreen GAGurtner PWhite LE: Intracranial pressure changes during intermittent CSF drainage. Pediatr Neurol 28:1731772003

    • Search Google Scholar
    • Export Citation
  • 8

    Been JVDegraeuwe PLKramer BWZimmermann LJ: Antenatal steroids and neonatal outcome after chorioamnionitis: a meta-analysis. BJOG 118:1131222011

    • Search Google Scholar
    • Export Citation
  • 9

    Been JVRours IGKornelisse RFLima Passos VKramer BWSchneider TA: Histologic chorioamnionitis, fetal involvement, and antenatal steroids: effects on neonatal outcome in preterm infants. Am J Obstet Gynecol 201:587.e1587.e82009

    • Search Google Scholar
    • Export Citation
  • 10

    Bhandari VBuhimschi CSHan CSLee SYPettker CMCampbell KH: Cord blood erythropoietin and interleukin-6 for prediction of intraventricular hemorrhage in the preterm neonate. J Matern Fetal Neonatal Med 24:6736792011

    • Search Google Scholar
    • Export Citation
  • 11

    Brockmeyer DLWright LCWalker MLWard RM: Management of posthemorrhagic hydrocephalus in the low-birth-weight preterm neonate. Pediatr Neurosci 15:3023081989

    • Search Google Scholar
    • Export Citation
  • 12

    Brouwer AGroenendaal Fvan Haastert ILRademaker KHanlo Pde Vries L: Neurodevelopmental outcome of preterm infants with severe intraventricular hemorrhage and therapy for post-hemorrhagic ventricular dilatation. J Pediatr 152:6486542008

    • Search Google Scholar
    • Export Citation
  • 13

    Brouwer AJGroenendaal Fvan den Hoogen Ade Vos JEde Vries LS: Ventricular reservoir punctures performed by nurses: an improvement in quality of care. Neonatal Netw 29:2432482010

    • Search Google Scholar
    • Export Citation
  • 14

    Brouwer AJGroenendaal Fvan den Hoogen AVerboon-Maciolek MHanlo PRademaker KJ: Incidence of infections of ventricular reservoirs in the treatment of post-haemorrhagic ventricular dilatation: a retrospective study (1992–2003). Arch Dis Child Fetal Neonatal Ed 92:F41F432007

    • Search Google Scholar
    • Export Citation
  • 15

    Brouwer MJde Vries LSPistorius LRademaker KJGroenendaal FBenders MJ: Ultrasound measurements of the lateral ventricles in neonates: why, how and when? A systematic review. Acta Paediatr 99:129813062010

    • Search Google Scholar
    • Export Citation
  • 16

    Brown MSEichorst DLala-Black BGonzalez R: Higher cumulative doses of erythropoietin and developmental outcomes in preterm infants. Pediatrics 124:e681e6872009

    • Search Google Scholar
    • Export Citation
  • 17

    Bruinsma NStobberingh EEHerpers MJVles JSWeber BJGavilanes DA: Subcutaneous ventricular catheter reservoir and ventriculoperitoneal drain-related infections in preterm infants and young children. Clin Microbiol Infect 6:2022062000

    • Search Google Scholar
    • Export Citation
  • 18

    Cherian SThoresen MSilver IAWhitelaw ALove S: Transforming growth factor-betas in a rat model of neonatal posthaemorrhagic hydrocephalus. Neuropathol Appl Neurobiol 30:5856002004

    • Search Google Scholar
    • Export Citation
  • 19

    Cherian SWhitelaw AThoresen MLove S: The pathogenesis of neonatal post-hemorrhagic hydrocephalus. Brain Pathol 14:3053112004

  • 20

    Chow LCSoliman AZandian MDanielpour MKrueger RC Jr: Accumulation of transforming growth factor-beta2 and nitrated chondroitin sulfate proteoglycans in cerebrospinal fluid correlates with poor neurologic outcome in preterm hydrocephalus. Biol Neonate 88:1112005

    • Search Google Scholar
    • Export Citation
  • 21

    Chua SJBielecki RYamanaka NFehlings MGRogers IMCasper RF: The effect of umbilical cord blood cells on outcomes after experimental traumatic spinal cord injury. Spine (Phila Pa 1976) 35:152015262010

    • Search Google Scholar
    • Export Citation
  • 22

    Dani CPoggi CBertini GPratesi SDi Tommaso MScarselli G: Method of delivery and intraventricular haemorrhage in extremely preterm infants. J Matern Fetal Neonatal Med 23:141914232010

    • Search Google Scholar
    • Export Citation
  • 23

    de Vries LSLiem KDvan Dijk KSmit BJSie LRademaker KJ: Early versus late treatment of posthaemorrhagic ventricular dilatation: results of a retrospective study from five neonatal intensive care units in The Netherlands. Acta Paediatr 91:2122172002

    • Search Google Scholar
    • Export Citation
  • 24

    du Plessis AJ: Cerebrovascular injury in premature infants: current understanding and challenges for future prevention. Clin Perinatol 35:609641v2008

    • Search Google Scholar
    • Export Citation
  • 25

    du Plessis AJ: The role of systemic hemodynamic disturbances in prematurity-related brain injury. J Child Neurol 24:112711402009

  • 26

    Ecury-Goossen GMDudink JLequin MFeijen-Roon MHorsch SGovaert P: The clinical presentation of preterm cerebellar haemorrhage. Eur J Pediatr 169:124912532010

    • Search Google Scholar
    • Export Citation
  • 27

    El-Dib MMassaro ANBulas DAly H: Neuroimaging and neurodevelopmental outcome of premature infants. Am J Perinatol 27:8038182010

    • Search Google Scholar
    • Export Citation
  • 28

    Elgamal EAEl-Dawlatly AAMurshid WREl-Watidy SMJamjoom ZA: Endoscopic third ventriculostomy for hydrocephalus in children younger than 1 year of age. Childs Nerv Syst 27:1111162011

    • Search Google Scholar
    • Export Citation
  • 29

    Engle WA: Age terminology during the perinatal period. Pediatrics 114:136213642004

  • 30

    Fanaroff JMFanaroff AA: Blood pressure disorders in the neonate: hypotension and hypertension. Semin Fetal Neonatal Med 11:1741812006

    • Search Google Scholar
    • Export Citation
  • 31

    Fauchère JCDame CVonthein RKoller BArri SWolf M: An approach to using recombinant erythropoietin for neuroprotection in very preterm infants. Pediatrics 122:3753822008

    • Search Google Scholar
    • Export Citation
  • 32

    Fowlie PWDavis PGMcGuire W: Prophylactic intravenous indomethacin for preventing mortality and morbidity in preterm infants. Cochrane Database Syst Rev 7:CD0001742010

    • Search Google Scholar
    • Export Citation
  • 33

    Fulkerson DHVachhrajani SBohnstedt BNPatel NBPatel AJFox BD: Analysis of the risk of shunt failure or infection related to cerebrospinal fluid cell count, protein level, and glucose levels in low-birth-weight premature infants with posthemorrhagic hydrocephalus. Clinical article. J Neurosurg Pediatr 7:1471512011

    • Search Google Scholar
    • Export Citation
  • 34

    Fulmer BBGrabb PAOakes WJMapstone TB: Neonatal ventriculosubgaleal shunts. Neurosurgery 47:80842000

  • 35

    Garay RPChiavaroli CHannaert P: Therapeutic efficacy and mechanism of action of ethamsylate, a long-standing hemostatic agent. Am J Ther 13:2362472006

    • Search Google Scholar
    • Export Citation
  • 36

    Göpel WHärtel CAhrens PKönig IKattner EKuhls E: Interleukin-6-174-genotype, sepsis and cerebral injury in very low birth weight infants. Genes Immun 7:65682006

    • Search Google Scholar
    • Export Citation
  • 37

    Halliday HLEhrenkranz RADoyle LW: Early (<8 days) postnatal corticosteroids for preventing chronic lung disease in preterm infants. Cochrane Database Syst Rev 20:CD0011462010

    • Search Google Scholar
    • Export Citation
  • 38

    Hamrick SEHansmann G: Patent ductus arteriosus of the preterm infant. Pediatrics 125:102010302010

  • 39

    Hansen ARVolpe JJGoumnerova LCMadsen JR: Intraventricular urokinase for the treatment of posthemorrhagic hydrocephalus. Pediatr Neurol 17:2132171997

    • Search Google Scholar
    • Export Citation
  • 40

    Heep ABartmann PStoffel-Wagner BBos AHoving EBrouwer O: Cerebrospinal fluid obstruction and malabsorption in human neonatal hydrocephaly. Childs Nerv Syst 22:124912552006

    • Search Google Scholar
    • Export Citation
  • 41

    Heep AStoffel-Wagner BBartmann PBenseler SSchaller CGroneck P: Vascular endothelial growth factor and transforming growth factor-beta1 are highly expressed in the cerebrospinal fluid of premature infants with posthemorrhagic hydrocephalus. Pediatr Res 56:7687742004

    • Search Google Scholar
    • Export Citation
  • 42

    Hintz SRKendrick DEWilson-Costello DEDas ABell EFVohr BR: Early-childhood neurodevelopmental outcomes are not improving for infants born at <25 weeks' gestational age. Pediatrics 127:62702011

    • Search Google Scholar
    • Export Citation
  • 43

    Hudgins RJBoydston WRGilreath CL: Treatment of posthemorrhagic hydrocephalus in the preterm infant with a ventricular access device. Pediatr Neurosurg 29:3093131998

    • Search Google Scholar
    • Export Citation
  • 44

    Hunt RHey E: Ethamsylate for the prevention of morbidity and mortality in preterm or very low birth weight infants. Cochrane Database Syst Rev 20:CD0043432010

    • Search Google Scholar
    • Export Citation
  • 45

    Indredavik MSVik TEvensen KASkranes JTaraldsen GBrubakk AM: Perinatal risk and psychiatric outcome in adolescents born preterm with very low birth weight or term small for gestational age. J Dev Behav Pediatr 31:2862942010

    • Search Google Scholar
    • Export Citation
  • 46

    Kallankari HKaukola TOjaniemi MHerva RPerhomaa MVuolteenaho R: Chemokine CCL18 predicts intraventricular hemorrhage in very preterm infants. Ann Med 42:4164252010

    • Search Google Scholar
    • Export Citation
  • 47

    Karas CSBaig MNElton SW: Ventriculosubgaleal shunts at Columbus Children's Hospital: neurosurgical implant placement in the neonatal intensive care unit. J Neurosurg 107:3 Suppl2202232007

    • Search Google Scholar
    • Export Citation
  • 48

    Kennedy CRAyers SCampbell MJElbourne DHope PJohnson A: Randomized, controlled trial of acetazolamide and furosemide in posthemorrhagic ventricular dilation in infancy: follow-up at 1 year. Pediatrics 108:5976072001

    • Search Google Scholar
    • Export Citation
  • 49

    Kidokoro HKubota THayashi NHayakawa MTakemoto KKato Y: Absent cyclicity on aEEG within the first 24 h is associated with brain damage in preterm infants. Neuropediatrics 41:2412452010

    • Search Google Scholar
    • Export Citation
  • 50

    Kormanik KPraca JGarton HJSarkar S: Repeated tapping of ventricular reservoir in preterm infants with post-hemorrhagic ventricular dilatation does not increase the risk of reservoir infection. J Perinatol 30:2182212010

    • Search Google Scholar
    • Export Citation
  • 51

    Krueger RC JrWu HZandian MDanielpour MKabos PYu JS: Neural progenitors populate the cerebrospinal fluid of preterm patients with hydrocephalus. J Pediatr 148:3373402006

    • Search Google Scholar
    • Export Citation
  • 52

    Kuint JBarak MMorag IMaayan-Metzger A: Early treated hypotension and outcome in very low birth weight infants. Neonatology 95:3113162009

    • Search Google Scholar
    • Export Citation
  • 53

    Kusters CDChen MLFollett PLDammann O: “Intraventricular” hemorrhage and cystic periventricular leukomalacia in preterm infants: how are they related?. J Child Neurol 24:115811702009

    • Search Google Scholar
    • Export Citation
  • 54

    Lam HPHeilman CB: Ventricular access device versus ventriculosubgaleal shunt in post hemorrhagic hydrocephalus associated with prematurity. J Matern Fetal Neonatal Med 22:109711012009

    • Search Google Scholar
    • Export Citation
  • 55

    Levene MI: Measurement of the growth of the lateral ventricles in preterm infants with real-time ultrasound. Arch Dis Child 56:9009041981

    • Search Google Scholar
    • Export Citation
  • 56

    Levy MLMasri LSMcComb JG: Outcome for preterm infants with germinal matrix hemorrhage and progressive hydrocephalus. Neurosurgery 41:111111181997

    • Search Google Scholar
    • Export Citation
  • 57

    Limbrick DD JrMathur AJohnston JMMunro RSagar JInder T: Neurosurgical treatment of progressive posthemorrhagic ventricular dilation in preterm infants: a 10-year single-institution study. Clinical article. J Neurosurg Pediatr 6:2242302010

    • Search Google Scholar
    • Export Citation
  • 58

    Limperopoulos CBassan HGauvreau KRobertson RL JrSullivan NRBenson CB: Does cerebellar injury in premature infants contribute to the high prevalence of long-term cognitive, learning, and behavioral disability in survivors?. Pediatrics 120:5845932007

    • Search Google Scholar
    • Export Citation
  • 59

    Lin CYChang YCWang STLee TYLin CFHuang CC: Altered inflammatory responses in preterm children with cerebral palsy. Ann Neurol 68:2042122010

    • Search Google Scholar
    • Export Citation
  • 60

    Linder NBello RHernandez ARosen CBirk ESirota L: Treatment of patent ductus arteriosus: indomethacin or ibuprofen?. Am J Perinatol 27:3994042010

    • Search Google Scholar
    • Export Citation
  • 61

    Liu JFeng ZCYin XJChen HLu JQiao X: The role of antenatal corticosteroids for improving the maturation of choroid plexus capillaries in fetal mice. Eur J Pediatr 167:120912122008

    • Search Google Scholar
    • Export Citation
  • 62

    Lockwood CJMurk WKKayisli UABuchwalder LFHuang SJArcuri F: Regulation of interleukin-6 expression in human decidual cells and its potential role in chorioamnionitis. Am J Pathol 177:175517642010

    • Search Google Scholar
    • Export Citation
  • 63

    Luu TMMent LRSchneider KCKatz KHAllan WCVohr BR: Lasting effects of preterm birth and neonatal brain hemorrhage at 12 years of age. Pediatrics 123:103710442009

    • Search Google Scholar
    • Export Citation
  • 64

    Maertzdorf WJVles JSBeuls EMulder ALBlanco CE: Intracranial pressure and cerebral blood flow velocity in preterm infants with posthaemorrhagic ventricular dilatation. Arch Dis Child Fetal Neonatal Ed 87:F185F1882002

    • Search Google Scholar
    • Export Citation
  • 65

    Maitre NLMarshall DDPrice WASlaughter JCO'Shea TMMaxfield C: Neurodevelopmental outcome of infants with unilateral or bilateral periventricular hemorrhagic infarction. Pediatrics 124:e1153e11602009

    • Search Google Scholar
    • Export Citation
  • 66

    Malaeb SDammann O: Fetal inflammatory response and brain injury in the preterm newborn. J Child Neurol 24:111911262009

  • 67

    Mathews TJMiniño AMOsterman MJStrobino DMGuyer B: Annual summary of vital statistics: 2008. Pediatrics 127:1461572011

  • 68

    Maunu JLehtonen LLapinleimu HMatomäki JMunck PRikalainen H: Ventricular dilatation in relation to outcome at 2 years of age in very preterm infants: a prospective Finnish cohort study. Dev Med Child Neurol 53:48542011

    • Search Google Scholar
    • Export Citation
  • 69

    Mazur MMiller RHRobinson S: Postnatal erythropoietin treatment mitigates neural cell loss after systemic prenatal hypoxic-ischemic injury. Laboratory investigation. J Neurosurg Pediatr 6:2062212010

    • Search Google Scholar
    • Export Citation
  • 70

    McComb JGRamos ADPlatzker ACHenderson DJSegall HD: Management of hydrocephalus secondary to intraventricular hemorrhage in the preterm infant with a subcutaneous ventricular catheter reservoir. Neurosurgery 13:2953001983

    • Search Google Scholar
    • Export Citation
  • 71

    McCrea HJMent LR: The diagnosis, management, and postnatal prevention of intraventricular hemorrhage in the preterm neonate. Clin Perinatol 35:777792vii2008

    • Search Google Scholar
    • Export Citation
  • 72

    Menon RFortunato SJEdwards DRWilliams SM: Association of genetic variants, ethnicity and preterm birth with amniotic fluid cytokine concentrations. Ann Hum Genet 74:1651832010

    • Search Google Scholar
    • Export Citation
  • 73

    Moscuzza FBelcari FNardini VBartoli ADomenici CCuttano A: Correlation between placental histopathology and fetal/neonatal outcome: chorioamnionitis and funisitis are associated to intraventricular haemorrage and retinopathy of prematurity in preterm newborns. Gynecol Endocrinol 27:3193232011

    • Search Google Scholar
    • Export Citation
  • 74

    Murphy BPInder TERooks VTaylor GAAnderson NJMogridge N: Posthaemorrhagic ventricular dilatation in the premature infant: natural history and predictors of outcome. Arch Dis Child Fetal Neonatal Ed 87:F37F412002

    • Search Google Scholar
    • Export Citation
  • 75

    Navaei FAliabady BMoghtaderi JMoghtaderi MKelishadi R: Early outcome of preterm infants with birth weight of 1500 g or less and gestational age of 30 weeks or less in Isfahan city, Iran. World J Pediatr 6:2282322010

    • Search Google Scholar
    • Export Citation
  • 76

    Neubauer APVoss WWachtendorf MJungmann T: Erythropoietin improves neurodevelopmental outcome of extremely preterm infants. Ann Neurol 67:6576662010

    • Search Google Scholar
    • Export Citation
  • 77

    O'Leary HGregas MCLimperopoulos CZaretskaya IBassan HSoul JS: Elevated cerebral pressure passivity is associated with prematurity-related intracranial hemorrhage. Pediatrics 124:3023092009

    • Search Google Scholar
    • Export Citation
  • 78

    O'Shea TMKuban KCAllred ENPaneth NPagano MDammann O: Neonatal cranial ultrasound lesions and developmental delays at 2 years of age among extremely low gestational age children. Pediatrics 122:e662e6692008

    • Search Google Scholar
    • Export Citation
  • 79

    Papile LABurstein JBurstein RKoffler H: Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr 92:5295341978

    • Search Google Scholar
    • Export Citation
  • 80

    Perret GEGraf CJ: Subgaleal shunt for temporary ventricle decompression and subdural drainage. J Neurosurg 47:5905951977

  • 81

    Perrone STataranno MLNegro SLLongini MMarzocchi BProietti F: Early identification of the risk for free radical-related diseases in preterm newborns. Early Hum Dev 86:2412442010

    • Search Google Scholar
    • Export Citation
  • 82

    Piatt JH: Editorial. Posthemorrhagic ventricular dilation. J Neurosurg Pediatr 6:2222232010

  • 83

    Pimentel-Coelho PMMendez-Otero R: Cell therapy for neonatal hypoxic-ischemic encephalopathy. Stem Cells Dev 19:2993102010

  • 84

    Pirotte BJLubansu ABruneau MLoqa CVan Cutsem NBrotchi J: Sterile surgical technique for shunt placement reduces the shunt infection rate in children: preliminary analysis of a prospective protocol in 115 consecutive procedures. Childs Nerv Syst 23:125112612007

    • Search Google Scholar
    • Export Citation
  • 85

    Rastogi SOlmez IBhutada ARastogi D: NCI classification of thrombocytopenia in extremely preterm neonates and its association with mortality and morbidity. J Perinat Med 39:65692011

    • Search Google Scholar
    • Export Citation
  • 86

    Rees SHale NDe Matteo RCardamone LTolcos MLoeliger M: Erythropoietin is neuroprotective in a preterm ovine model of endotoxin-induced brain injury. J Neuropathol Exp Neurol 69:3063192010

    • Search Google Scholar
    • Export Citation
  • 87

    Robertson CMWatt MJDinu IA: Outcomes for the extremely premature infant: what is new? And where are we going?. Pediatr Neurol 40:1891962009

    • Search Google Scholar
    • Export Citation
  • 88

    Sajjadian NFakhrai HJahadi R: Incidence of intraventricular hemorrhage and post hemorrhagic hydrocephalus in preterm infants. Acta Med Iran 48:2602622010

    • Search Google Scholar
    • Export Citation
  • 89

    Scavarda DBednarek NLitre FKoch CLena GMorville P: Acquired aqueductal stenosis in preterm infants: an indication for neuroendoscopic third ventriculostomy. Childs Nerv Syst 19:7567592003

    • Search Google Scholar
    • Export Citation
  • 90

    Schmidt BRoberts RSDavis PDoyle LWBarrington KJOhlsson A: Long-term effects of caffeine therapy for apnea of prematurity. N Engl J Med 357:189319022007

    • Search Google Scholar
    • Export Citation
  • 91

    Schmitz THeep AGroenendaal FHüseman DKie SBartmann P: Interleukin-1beta, interleukin-18, and interferon-gamma expression in the cerebrospinal fluid of premature infants with posthemorrhagic hydrocephalus—markers of white matter damage?. Pediatr Res 61:7227262007

    • Search Google Scholar
    • Export Citation
  • 92

    Sciubba DMNoggle JCCarson BSJallo GI: Antibiotic-impregnated shunt catheters for the treatment of infantile hydrocephalus. Pediatr Neurosurg 44:91962008

    • Search Google Scholar
    • Export Citation
  • 93

    Shatrov JGBirch SCLam LTQuinlivan JAMcIntyre SMendz GL: Chorioamnionitis and cerebral palsy: a metaanalysis. Obstet Gynecol 116:3873922010

    • Search Google Scholar
    • Export Citation
  • 94

    Shooman DPortess HSparrow O: A review of the current treatment methods for posthaemorrhagic hydrocephalus of infants. Cerebrospinal Fluid Res 6:12009

    • Search Google Scholar
    • Export Citation
  • 95

    Soll ROzek E: Prophylactic protein free synthetic surfactant for preventing morbidity and mortality in preterm infants. Cochrane Database Syst Rev 20:CD0010792010

    • Search Google Scholar
    • Export Citation
  • 96

    Sondhi VGupta GGupta PKPatnaik SKTshering K: Establishment of nomograms and reference ranges for intracranial ventricular dimensions and ventriculo-hemispheric ratio in newborns by ultrasonography. Acta Paediatr 97:7387442008

    • Search Google Scholar
    • Export Citation
  • 97

    Soraisham ASSinghai NMcMillan DDSauve RSLee SK: A multicenter study on the clinical outcome of chorioamnionitis in preterm infants. Am J Obstet Gynecol 200:372.e1372.e62009

    • Search Google Scholar
    • Export Citation
  • 98

    Sorokin YRomero RMele LWapner RJIams JDDudley DJ: Maternal serum interleukin-6, C-reactive protein, and matrix metalloproteinase-9 concentrations as risk factors for preterm birth <32 weeks and adverse neonatal outcomes. Am J Perinatol 27:6316402010

    • Search Google Scholar
    • Export Citation
  • 99

    Standridge SM: Idiopathic intracranial hypertension in children: a review and algorithm. Pediatr Neurol 43:3773902010

  • 100

    Stoll BJHansen NIBell EFShankaran SLaptook ARWalsh MC: Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network. Pediatrics 126:4434562010

    • Search Google Scholar
    • Export Citation
  • 101

    Tam EWMiller SPStudholme CChau VGlidden DPoskitt KJ: Differential effects of intraventricular hemorrhage and white matter injury on preterm cerebellar growth. J Pediatr 158:3663712011

    • Search Google Scholar
    • Export Citation
  • 102

    Tam EWRosenbluth GRogers EEFerriero DMGlidden DGoldstein RB: Cerebellar hemorrhage on magnetic resonance imaging in preterm newborns associated with abnormal neurologic outcome. J Pediatr 158:2452502011

    • Search Google Scholar
    • Export Citation
  • 103

    Tanaka NKamei NNakamae TYamamoto RIshikawa MFujiwara H: CD133+ cells from human umbilical cord blood reduce cortical damage and promote axonal growth in neonatal rat organ co-cultures exposed to hypoxia. Int J Dev Neurosci 28:5815872010

    • Search Google Scholar
    • Export Citation
  • 104

    Tao JDMathur AM: Using amplitude-integrated EEG in neonatal intensive care. J Perinatol 30:SupplS73S812010

  • 105

    Taylor AGPeter JC: Advantages of delayed VP shunting in post-haemorrhagic hydrocephalus seen in low-birth-weight infants. Childs Nerv Syst 17:3283332001

    • Search Google Scholar
    • Export Citation
  • 106

    Tubbs RSBanks JTSoleau SSmyth MDWellons JC IIIBlount JP: Complications of ventriculosugbaleal shunts in infants and children. Childs Nerv Syst 21:48512005

    • Search Google Scholar
    • Export Citation
  • 107

    van Alfen-van der Velden AAHopman JCKlaessens JHFeuth TSengers RCLiem KD: Cerebral hemodynamics and oxygenation of serial CSF drainage in infants with PHVD. Brain Dev 29:6236292007

    • Search Google Scholar
    • Export Citation
  • 108

    van Haastert ICGroenendaal FUiterwaal CSTermote JUvan der Heide-Jalving MEijsermans MJ: Decreasing incidence and severity of cerebral palsy in prematurely born children. J Pediatr 159:8691e12011

    • Search Google Scholar
    • Export Citation
  • 109

    Vannemreddy PNotarianni CYanamandra KNapper DBocchini J: Is an endothelial nitric oxide synthase gene mutation a risk factor in the origin of intraventricular hemorrhage?. Neurosurg Focus 28:1E112010

    • Search Google Scholar
    • Export Citation
  • 110

    Vasileiadis GTGelman NHan VKWilliams LAMann RBureau Y: Uncomplicated intraventricular hemorrhage is followed by reduced cortical volume at near-term age. Pediatrics 114:E367E3722004

    • Search Google Scholar
    • Export Citation
  • 111

    Vassilyadi MTataryn ZShamji MFVentureyra EC: Functional outcomes among premature infants with intraventricular hemorrhage. Pediatr Neurosurg 45:2472552009

    • Search Google Scholar
    • Export Citation
  • 112

    Vela-Huerta MMAmador-Licona MMedina-Ovando NAldana-Valenzuela C: Factors associated with early severe intraventricular haemorrhage in very low birth weight infants. Neuropediatrics 40:2242272009

    • Search Google Scholar
    • Export Citation
  • 113

    Verhagen EATer Horst HJKeating PMartijn AVan Braeckel KNBos AF: Cerebral oxygenation in preterm infants with germinal matrix-intraventricular hemorrhages. Stroke 41:290129072010

    • Search Google Scholar
    • Export Citation
  • 114

    Viscardi RM: Ureaplasma species: role in diseases of prematurity. Clin Perinatol 37:3934092010

  • 115

    Volpe JJ: Neurology of the Newborn ed 5PhiladelphiaSaunders Elsevier2008

  • 116

    Volpe JJKinney HCJensen FERosenberg PA: The developing oligodendrocyte: key cellular target in brain injury in the premature infant. Int J Dev Neurosci 29:4234402011

    • Search Google Scholar
    • Export Citation
  • 117

    Warf BCCampbell JWRiddle E: Initial experience with combined endoscopic third ventriculostomy and choroid plexus cauterization for post-hemorrhagic hydrocephalus of prematurity: the importance of prepontine cistern status and the predictive value of FIESTA MRI imaging. Childs Nerv Syst 27:106310712011

    • Search Google Scholar
    • Export Citation
  • 118

    Whitelaw A: Repeated lumbar or ventricular punctures in newborns with intraventricular hemorrhage. Cochrane Database Syst Rev 1:CD0002162001

    • Search Google Scholar
    • Export Citation
  • 119

    Whitelaw AAquilina K: Management of posthaemorrhagic ventricular dilatation. Arch Dis Child Fetal Neonatal Ed [epub ahead of print]2011

    • Search Google Scholar
    • Export Citation
  • 120

    Whitelaw AEvans DCarter MThoresen MWroblewska JMandera M: Randomized clinical trial of prevention of hydrocephalus after intraventricular hemorrhage in preterm infants: brain-washing versus tapping fluid. Pediatrics 119:e1071e10782007

    • Search Google Scholar
    • Export Citation
  • 121

    Whitelaw AJary SKmita GWroblewska JMusialik-Swietlinska EMandera M: Randomized trial of drainage, irrigation and fibrinolytic therapy for premature infants with posthemorrhagic ventricular dilatation: developmental outcome at 2 years. Pediatrics 125:e852e8582010

    • Search Google Scholar
    • Export Citation
  • 122

    Whitelaw AKennedy CRBrion LP: Diuretic therapy for newborn infants with posthemorrhagic ventricular dilatation. Cochrane Database Syst Rev 2:CD0022702001

    • Search Google Scholar
    • Export Citation
  • 123

    Whitelaw AOdd D: Postnatal phenobarbital for the prevention of intraventricular hemorrhage in preterm infants. Cochrane Database Syst Rev 4:CD0016912007

    • Search Google Scholar
    • Export Citation
  • 124

    Whitelaw AOdd DE: Intraventricular streptokinase after intraventricular hemorrhage in newborn infants. Cochrane Database Syst Rev 4:CD0004982007

    • Search Google Scholar
    • Export Citation
  • 125

    Whitelaw APople ICherian SEvans DThoresen M: Phase 1 trial of prevention of hydrocephalus after intraventricular hemorrhage in newborn infants by drainage, irrigation, and fibrinolytic therapy. Pediatrics 111:7597652003

    • Search Google Scholar
    • Export Citation
  • 126

    Willis BJavalkar VVannemreddy PCaldito GMatsuyama JGuthikonda B: Ventricular reservoirs and ventriculoperitoneal shunts for premature infants with posthemorrhagic hydrocephalus: an institutional experience. Clinical article. J Neurosurg Pediatr 3:941002009

    • Search Google Scholar
    • Export Citation
  • 127

    Wilson-Costello DFriedman HMinich NSiner BTaylor GSchluchter M: Improved neurodevelopmental outcomes for extremely low birth weight infants in 2000–2002. Pediatrics 119:37452007

    • Search Google Scholar
    • Export Citation
  • 128

    Yapicioğlu HNarli NSatar MSoyupak SAltunbaşak S: Intraventricular streptokinase for the treatment of posthaemorrhagic hydrocephalus of preterm. J Clin Neurosci 10:2972992003

    • Search Google Scholar
    • Export Citation
  • 129

    Yasuhara THara KMaki MXu LYu GAli MM: Mannitol facilitates neurotrophic factor up-regulation and behavioural recovery in neonatal hypoxic-ischaemic rats with human umbilical cord blood grafts. J Cell Mol Med 14:9149212010

    • Search Google Scholar
    • Export Citation
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