Brain metastasis of Wilms tumor with diffuse anaplasia and complex cytogenetic phenotype in a child with neurofibromatosis Type 1

Case report

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  • 1 Departments of Pathology and
  • 2 Neurosurgery, New York University; and
  • 3 Division of Pediatric Neurosurgery, New York University Langone Medical Center, New York, New York
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The authors report the first case of a Wilms tumor (WT) with diffuse anaplasia metastatic to the brain in a 13-year-old girl with a history of neurofibromatosis Type 1. At presentation, the metastatic tumor had radiological features that suggested a meningioma. Histologically it was characterized by striking anaplasia and features similar to the patient's previously resected WT with diffuse anaplasia.

Abbreviations used in this paper: AE1/AE3 = low- and high-molecular-weight cytokeratin; NF1 = neurofibromatosis Type 1; WT = Wilms tumor.

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Contributor Notes

Address correspondence to: Marianna Shvartsbeyn, M.D., Department of Pathology, New York University, 522 First Avenue, Smilow, 301C, New York, New York 10016. email: Marianna.Shvartsbeyn@nyumc.org.
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