Hypothalamic lipoma associated with severe obesity

Report of 2 cases

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The association between hypothalamic dysfunction and obesity is well documented in both clinical and experimental models. The authors describe 2 children who developed obesity that could not be explained by endocrinological, genetic, or eating disorders. In both cases, cranial MR imaging revealed the typical appearance of a lipoma in the paramedian hypothalamus. In the absence of other etiologies, the authors hypothesized that in these 2 children obesity was caused by their hypothalamic lipomas. To the authors' knowledge, these are the first cases of hypothalamic lipomas likely to be causing obesity that have been described in children. These cases highlight the importance of performing cranial MR imaging in children with otherwise unexplained obesity.

Abbreviations used in this paper: BMI = body mass index; TSH = thyroid-stimulating hormone.
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Contributor Notes

Address correspondence to: Stéphanie Puget, M.D., Department of Neurosurgery, Hôpital Necker–Enfants-Malades, 149 rue de Sèvres, 75015 Paris, France. email: stephanie.puget@nck.aphp.fr.
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