Wound closure with a mesh and liquid tissue adhesive (Dermabond Prineo) system in pediatric spine surgery: a prospective single-center cohort study incorporating parent-reported outcome measures

Sarah StrickerDepartment of Pediatric Neurosurgery, Children’s University Hospital of Basel;
Department of Neurosurgery, University Hospital of Basel;

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Noëmi EberhardDepartment of Pediatric Neurosurgery, Children’s University Hospital of Basel;
Department of Neurosurgery, University Hospital of Basel;

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Maria LicciDepartment of Pediatric Neurosurgery, Children’s University Hospital of Basel;
Department of Neurosurgery, University Hospital of Basel;

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Ladina GreuterDepartment of Pediatric Neurosurgery, Children’s University Hospital of Basel;
Department of Neurosurgery, University Hospital of Basel;

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Christian ZweifelDepartment of Neurosurgery, University Hospital of Basel;
Faculty of Medicine, University of Basel;
Division of Neurosurgery, Department of Surgery, Kantonsspital Graubünden, Chur; and

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Raphael GuzmanDepartment of Pediatric Neurosurgery, Children’s University Hospital of Basel;
Department of Neurosurgery, University Hospital of Basel;
Faculty of Medicine, University of Basel;

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Jehuda SolemanDepartment of Pediatric Neurosurgery, Children’s University Hospital of Basel;
Department of Neurosurgery, University Hospital of Basel;
Faculty of Medicine, University of Basel;
Clinical Trial Unit, University Hospital of Basel, Switzerland

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OBJECTIVE

Wound healing can be challenging in children undergoing spine surgery for neurological conditions due to a high risk of cerebrospinal fluid (CSF) leakage and wound infection. In adults, use of the Dermabond Prineo (DP) skin closure system, which consists of both tissue adhesive glue and a self-adhesive mesh, for wound closure of medium-length surgical incisions has been reported. The aim of this study was to investigate the efficiency and cosmetic outcome of DP for wound closure in extra- and intradural pediatric neurological spine surgery.

METHODS

In this prospective cohort study, 47 children underwent 50 spine procedures using DP for wound closure between 2018 and 2022 at a single institution. Patient demographic and surgical data were collected. The primary outcome was revision surgery for wound healing disorders, while secondary outcomes were infections, minor wound healing disorders, and both physician and parental satisfaction (parent-reported outcome measures [PROMs]) at last follow-up.

RESULTS

Among 50 spinal (45 intra- and 5 extradural) interventions, 1 patient (2%) underwent revision surgery for a cutaneous CSF fistula and pseudomeningocele. Minor wound healing disorders occurred after 16 surgeries, which did not require surgical wound revision and resolved completely. No allergic reactions to DP or surgical site infections within 30 days were observed. The parents and the medical team described wound care as significantly facilitated since wound dressing changes were not needed. Three families (6.4%) encountered difficulties in wound care, and 46 (97.9%) were satisfied with DP. The cosmetic outcome based on PROMs was excellent, with a mean score of 8 (IQR 2) on a scale from 1 to 10. At long-term follow-up, a mean of 11.3 ± 10.7 months after surgery, physicians rated the cosmetic outcome on the visual analog scale (median score 9, IQR 1) and Hollander scale (median score 6, IQR 1). The outcomes were similar among the different pathologies and age groups and did not differ in patients with and without syndromic malformations.

CONCLUSIONS

The application of DP is simple, enables good patient comfort, facilitates both professional and parental wound care, and leads to excellent cosmetic results. DP possibly aids in the reduction of postoperative CSF leakage and infections after pediatric neurological spine surgery.

ABBREVIATIONS

CSF = cerebrospinal fluid; DP = Dermabond Prineo; PROM = parent-reported outcome measure; VAS = visual analog scale.

Supplementary Materials

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Images from Chiang et al. (pp 595–601).

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