Reversal of sedation with flumazenil in a child after traumatic brain injury

Case report

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The authors report on a case of successful reversal of sedation with flumazenil, a benzodiazepine antagonist, in a child following a moderate traumatic brain injury and demonstrate the utility of flumazenil to reverse benzodiazepine effects in traumatically injured children.

Abbreviations used in this paper: GABA = Gamma-amniobutyric acid; GCS = Glasgow Coma Scale; ICP = intracranial pressure; TBI = traumatic brain injury.

Article Information

Address correspondence to: P. David Adelson, M.D., Phoenix Children's Neuroscience Institute, 1919 East Thomas Road, Building B, 4th Floor, Phoenix, Arizona 85016. email:

© AANS, except where prohibited by US copyright law.



  • View in gallery

    Unenhanced CT scans. A and B: A small epidural hematoma is shown in the right frontotemopral region (arrowheads) without midline shift or significant edema. C: Fracture into the greater wing of the sphenoid with a small focus of pneumocephalus (arrow) is shown. Inset: Higher magnification image of the sphenoid fracture. D: Follow-up image showing stable size of the epidural hematoma 4 hours after the initial CT scan (arrowheads).

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    Timeline of events with associated GCS scores.


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