Corpus callosotomy for treatment of drug-resistant epilepsy: a review of 16 pediatric cases in northern Vietnam

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  • 1 Neurosurgical Department, Vietnam National Cancer Hospital, Hanoi;
  • 2 Neurology Department, National Hospital of Pediatrics, Hanoi, Vietnam;
  • 3 Department of Neurosurgery, University of Alabama at Birmingham, Alabama; and
  • 4 The Program in Global Surgery and Social Change, Harvard Medical School, Boston, Massachusetts
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OBJECTIVE

The aim of this study was to evaluate postoperative seizure outcome in children with drug-resistant epilepsy not eligible for focal resection who underwent corpus callosotomy.

METHODS

The study included 16 patients undergoing corpus callosotomy between September 2015 and May 2018. Seizure semiology and frequency, psychomotor status, and video electroencephalography and imaging findings were evaluated for all patients.

RESULTS

Of the 16 patients who underwent callosotomy during the study period, 11 underwent complete callosotomy and 5 underwent anterior only. Seizure improvement greater than 75% was achieved in 37.5% of patients, and another 50% of patients had seizure improvement of 50%–75%. No sustained neurological deficits were observed in these patients. There were no significant complications. Duration of postoperative follow-up ranged from 12 to 44 months.

CONCLUSIONS

Corpus callosotomy is an effective treatment for selected patients with drug-resistant epilepsy not eligible for focal resection in resource-limited settings. Fostering and developing international epilepsy surgery centers should remain a high priority for the neurosurgical community at large.

ABBREVIATIONS AEDs = antiepileptic drugs; Denver-II = Denver Developmental Screening Test, 2nd edition; MRE = medically refractory epilepsy; VEEG = video electroencephalography.

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Contributor Notes

Correspondence Jacob R. Lepard: University of Alabama at Birmingham, AL. jlepard@uabmc.edu.

INCLUDE WHEN CITING Published online February 28, 2020; DOI: 10.3171/2019.12.PEDS19638.

Disclosures The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper.

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