Stereotactic radiosurgery for pediatric brain arteriovenous malformations: long-term outcomes

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  • 1 Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia;
  • 2 Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital;
  • 3 School of Medicine, National Yang-Ming University, Taipei, Taiwan;
  • 4 Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania;
  • 5 Department of Neurosurgery, University of Louisville School of Medicine, Louisville, Kentucky;
  • 6 Department of Neurosurgery, Cleveland Clinic Foundation, Cleveland, Ohio;
  • 7 Department of Neurosurgery, New York University Langone Medical Center, New York, New York;
  • 8 Division of Neurosurgery, Centre de recherché du CHUS, University of Sherbrooke, Sherbrooke, Quebec, Canada;
  • 9 Department of Radiation Oncology, Beaumont Health System, Royal Oak, Michigan; and
  • 10 Section of Neurological Surgery, University of Puerto Rico, San Juan, Puerto Rico
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OBJECTIVE

Contrary to the better described obliteration- and hemorrhage-related data after stereotactic radiosurgery (SRS) of brain arteriovenous malformations (AVMs) in pediatric patients, estimates of the rarer complications, including cyst and tumor formation, are limited in the literature. The aim of the present study was to assess the long-term outcomes and risks of SRS for AVMs in pediatric patients (age < 18 years).

METHODS

The authors retrospectively analyzed the International Radiosurgery Research Foundation pediatric AVM database for the years 1987 to 2018. AVM obliteration, post-SRS hemorrhage, cyst formation, and tumor formation were assessed. Cumulative probabilities, adjusted for the competing risk of death, were calculated.

RESULTS

The study cohort comprised 539 pediatric AVM patients (mean follow-up 85.8 months). AVM obliteration was observed in 64.3% of patients, with cumulative probabilities of 63.6% (95% CI 58.8%–68.0%), 77.1% (95% CI 72.1%–81.3%), and 88.1% (95% CI 82.5%–92.0%) over 5, 10, and 15 years, respectively. Post-SRS hemorrhage was observed in 8.4% of patients, with cumulative probabilities of 4.9% (95% CI 3.1%–7.2%), 9.7% (95% CI 6.4%–13.7%), and 14.5% (95% CI 9.5%–20.5%) over 5, 10, and 15 years, respectively. Cyst formation was observed in 2.1% of patients, with cumulative probabilities of 5.5% (95% CI 2.3%–10.7%) and 6.9% (95% CI 3.1%–12.9%) over 10 and 15 years, respectively. Meningiomas were observed in 2 patients (0.4%) at 10 and 12 years after SRS, with a cumulative probability of 3.1% (95% CI 0.6%–9.7%) over 15 years.

CONCLUSIONS

AVM obliteration can be expected after SRS in the majority of the pediatric population, with a relatively low risk of hemorrhage during the latency period. Cyst and benign tumor formation after SRS can be observed in 7% and 3% of patients over 15 years, respectively. Longitudinal surveillance for delayed neoplasia is prudent despite its low incidence.

ABBREVIATIONS AVM = arteriovenous malformation; EBRT = external-beam radiation therapy; IRRF = International Radiosurgery Research Foundation; RIC = radiation-induced change; SM = Spetzler-Martin; SRS = stereotactic radiosurgery.

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Contributor Notes

Correspondence Jason P. Sheehan: University of Virginia Health System, Charlottesville, VA. jsheehan@virginia.edu.

INCLUDE WHEN CITING Published online February 7, 2020; DOI: 10.3171/2019.12.PEDS19595.

Disclosures Dr. Grills reports less than 5% stock ownership in Greater Michigan Gamma Knife, where she also serves on the executive board of directors. Dr. Lunsford reports stock ownership in Elekta AB; he is a consultant for Insightec and DSMB. Dr. Kondziolka reports funding from Brainlab for research support in brain tumor imaging (not related to this study).

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