Long-term follow-up of intensive chemotherapy followed by reduced-dose and reduced-field irradiation for intracranial germ cell tumor

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In Brief

In this study of patients with intracranial germ cell tumors, intensive chemotherapy followed by reduced-dose and reduced-field irradiation had the same outcome as that reported in the literature, but late adverse effects after treatment were observed. Although almost all of the complications were relatively mild, they had the potential to lead to psychiatric disorders and intracranial hemorrhaging. The data of long-term follow-up beyond 10 years will prove valuable.

ABBREVIATIONS AFP = alpha-fetoprotein; CDC = conventional-dose chemotherapy; CMB = cerebral microbleed; CRT = chemoradiotherapy; CSI = craniospinal irradiation; EP = etoposide and cisplatin; GCT = germ cell tumor; HCG = human chorionic gonadotropin; HDC = high-dose chemotherapy; ICE = ifosfamide, cisplatin, and etoposide; NGGCT = nongerminomatous GCT; OS = overall survival; PBSCT = peripheral blood stem cell transplantation; PFS = progression-free survival; RICM = radiation-induced cavernous malformation; STGC = syncytiotrophoblastic giant cell; SWI = susceptibility-weighted imaging.

Article Information

Correspondence Akinori Takada: Mie University Hospital, Tsu City, Mie, Japan. a-takada@clin.medic.mie-u.ac.jp.

INCLUDE WHEN CITING Published online November 23, 2018; DOI: 10.3171/2018.9.PEDS18181.

Disclosures The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper.

© AANS, except where prohibited by US copyright law.



  • View in gallery

    Kaplan-Meier survival curves of the OS (left) and PFS (right) rates for all 24 patients. Dashed lines represent 95% confidence intervals.

  • View in gallery

    Kaplan-Meier survival curves of the OS rates according to the histological subtype (left) and primary lesion (right).



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