Hypertrophic olivary degeneration in a child following midbrain tumor resection: longitudinal diffusion tensor imaging studies

Case report

View More View Less
  • 1 Section of Pediatric Neuroradiology, Division of Pediatric Radiology, Russell H. Morgan Department of Radiology and Radiological Science; and
  • 2 Division of Pediatric Neurosurgery, The Johns Hopkins School of Medicine, Baltimore, Maryland
Restricted access

Purchase Now

USD  $45.00

JNS + Pediatrics - 1 year subscription bundle (Individuals Only)

USD  $505.00

JNS + Pediatrics + Spine - 1 year subscription bundle (Individuals Only)

USD  $600.00
Print or Print + Online

Hypertrophic olivary degeneration (HOD) is a dynamic process caused by disruptive lesions affecting components of the Guillain-Mollaret triangle (GMT). The authors applied diffusion tensor imaging (DTI) to investigate longitudinal changes of the GMT components in a child with HOD after neurosurgery for a midbrain tumor. Diffusion tensor imaging data were acquired on a 1.5-T MRI scanner using a balanced pair of diffusion gradients along 20 noncollinear directions 1 day and 3, 6, and 9 months after surgery. Measurements from regions of interest (ROIs) were sampled in the affected inferior olivary nucleus, ipsilateral red nucleus, and contralateral superior and inferior cerebellar peduncles and dentate nucleus. For each ROI, fractional anisotropy and the mean, axial, and radial diffusivities were calculated. In the affected inferior olivary nucleus, the authors found a decrease in fractional anisotropy and an increase in mean, axial, and radial diffusivities 3 months after surgery, while 3 months later fractional anisotropy increased and diffusivities decreased. For all other GMT components, changes in DTI scalars were less pronounced, and fractional anisotropy mildly decreased over time. A detailed analysis of longitudinal DTI scalars in the various GMT components may shed light on a better understanding of the dynamic complex histopathological processes occurring in pediatric HOD over time.

Abbreviations used in this paper:DTI = diffusion tensor imaging; GMT = Guillain-Mollaret triangle; HOD = hypertrophic olivary degeneration; ROI = region of interest.

JNS + Pediatrics - 1 year subscription bundle (Individuals Only)

USD  $505.00

JNS + Pediatrics + Spine - 1 year subscription bundle (Individuals Only)

USD  $600.00

Contributor Notes

Address correspondence to: Andrea Poretti, M.D., Section of Pediatric Neuroradiology, Division of Pediatric Radiology, Russell H. Morgan Department of Radiology and Radiological Science, Charlotte R. Bloomberg Children's Center, Sheikh Zayed Tower, Rm. 4174, 1800 Orleans St., Baltimore, MD 21287. email: aporett1@jhmi.edu.

Please include this information when citing this paper: published online February 14, 2014; DOI: 10.3171/2014.1.PEDS13490.

  • 1

    Birbamer G, , Buchberger W, , Felber S, & Aichner F: MR appearance of hypertrophic olivary degeneration: temporal relationships. AJNR Am J Neuroradiol 13:15011503, 1992

    • Search Google Scholar
    • Export Citation
  • 2

    Birbamer G, , Gerstenbrand F, , Aichner F, , Buchberger W, , Chemelli A, & Langmayr J, : MR-imaging of post-traumatic olivary hypertrophy. Funct Neurol 9:183187, 1994

    • Search Google Scholar
    • Export Citation
  • 3

    De Zeeuw CI, , Simpson JI, , Hoogenraad CC, , Galjart N, , Koekkoek SK, & Ruigrok TJ: Microcircuitry and function of the inferior olive. Trends Neurosci 21:391400, 1998

    • Search Google Scholar
    • Export Citation
  • 4

    Dinçer A, , Özyurt O, , Kaya D, , Koşak E, , Öztürk C, & Erzen C, : Diffusion tensor imaging of Guillain-Mollaret triangle in patients with hypertrophic olivary degeneration. J Neuroimaging 21:145151, 2011

    • Search Google Scholar
    • Export Citation
  • 5

    Feldman HM, , Yeatman JD, , Lee ES, , Barde LH, & Gaman-Bean S: Diffusion tensor imaging: a review for pediatric researchers and clinicians. J Dev Behav Pediatr 31:346356, 2010

    • Search Google Scholar
    • Export Citation
  • 6

    Goto N, & Kaneko M: Olivary enlargement: chronological and morphometric analyses. Acta Neuropathol 54:275282, 1981

  • 7

    Goyal M, , Versnick E, , Tuite P, , Cyr JS, , Kucharczyk W, & Montanera W, : Hypertrophic olivary degeneration: metaanalysis of the temporal evolution of MR findings. AJNR Am J Neuroradiol 21:10731077, 2000

    • Search Google Scholar
    • Export Citation
  • 8

    Habas C, , Guillevin R, & Abanou A: In vivo structural and functional imaging of the human rubral and inferior olivary nuclei: a mini-review. Cerebellum 9:167173, 2010

    • Search Google Scholar
    • Export Citation
  • 9

    Hornyak M, , Osborn AG, & Couldwell WT: Hypertrophic olivary degeneration after surgical removal of cavernous malformations of the brain stem: report of four cases and review of the literature. Acta Neurochir (Wien) 150:149156, 2008

    • Search Google Scholar
    • Export Citation
  • 10

    Jellinger K: Hypertrophy of the inferior olives. Report on 29 cases. Z Neurol 205:153174, 1973

  • 11

    Kitajima M, , Korogi Y, , Shimomura O, , Sakamoto Y, , Hirai T, & Miyayama H, : Hypertrophic olivary degeneration: MR imaging and pathologic findings. Radiology 192:539543, 1994

    • Search Google Scholar
    • Export Citation
  • 12

    Meoded A, , Poretti A, , Ilica AT, , Perez R, , Jallo G, & Burger PC, : Diffusion tensor imaging in a child with hypertrophic olivary degeneration. Cerebellum 12:469474, 2013

    • Search Google Scholar
    • Export Citation
  • 13

    Pajevic S, & Pierpaoli C: Color schemes to represent the orientation of anisotropic tissues from diffusion tensor data: application to white matter fiber tract mapping in the human brain. Magn Reson Med 42:526540, 1999

    • Search Google Scholar
    • Export Citation
  • 14

    Phatouros CC, & McConachie NS: Hypertrophic olivary degeneration: case report in a child. Pediatr Radiol 28:830831, 1998

  • 15

    Poretti A, , Meoded A, , Rossi A, , Raybaud C, & Huisman TA: Diffusion tensor imaging and fiber tractography in brain malformations. Pediatr Radiol 43:2854, 2013

    • Search Google Scholar
    • Export Citation
  • 16

    Sanverdi SE, , Oguz KK, & Haliloglu G: Hypertrophic olivary degeneration in children: four new cases and a review of the literature with an emphasis on the MRI findings. Br J Radiol 85:511516, 2012

    • Search Google Scholar
    • Export Citation
  • 17

    Shah R, , Markert J, , Bag AK, & Curé JK: Diffusion tensor imaging in hypertrophic olivary degeneration. AJNR Am J Neuroradiol 31:17291731, 2010

    • Search Google Scholar
    • Export Citation
  • 18

    Shaikh AG, , Hong S, , Liao K, , Tian J, , Solomon D, & Zee DS, : Oculopalatal tremor explained by a model of inferior olivary hypertrophy and cerebellar plasticity. Brain 133:923940, 2010

    • Search Google Scholar
    • Export Citation
  • 19

    Shinohara Y, , Kinoshita T, , Kinoshita F, , Kaminou T, , Watanabe T, & Ogawa T: Hypertrophic olivary degeneration after surgical resection of brain tumors. Acta Radiol [epub ahead of print], 2013

    • Search Google Scholar
    • Export Citation
  • 20

    Tarnutzer AA, , Palla A, , Marti S, , Schuknecht B, & Straumann D: Hypertrophy of the inferior olivary nucleus impacts perception of gravity. Front Neurol 3:79, 2012

    • Search Google Scholar
    • Export Citation
  • 21

    Vossough A, , Ziai P, & Chatzkel JA: Red nucleus degeneration in hypertrophic olivary degeneration after pediatric posterior fossa tumor resection: use of susceptibility-weighted imaging (SWI). Pediatr Radiol 42:481485, 2012

    • Search Google Scholar
    • Export Citation
  • 22

    Winston GP, , Daga P, , Stretton J, , Modat M, , Symms MR, & McEvoy AW, : Optic radiation tractography and vision in anterior temporal lobe resection. Ann Neurol 71:334341, 2012

    • Search Google Scholar
    • Export Citation
  • 23

    Yogarajah M, , Focke NK, , Bonelli S, , Cercignani M, , Acheson J, & Parker GJ, : Defining Meyer's loop-temporal lobe resections, visual field deficits and diffusion tensor tractography. Brain 132:16561668, 2009

    • Search Google Scholar
    • Export Citation

Metrics

All Time Past Year Past 30 Days
Abstract Views 216 164 17
Full Text Views 214 7 0
PDF Downloads 220 5 0
EPUB Downloads 0 0 0