Osteosarcoma of the cranial vault and skull base in pediatric patients

Report of 3 cases

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  • 1 Department of Neurosurgery, Baylor College of Medicine and Division of Pediatric Neurosurgery, Texas Children's Hospital;
  • | 2 Department of Pediatrics, Baylor College of Medicine, Division of Hematology and Oncology, Texas Children's Hospital, Houston, Texas; and
  • | 3 Department of Neurosurgery, University of Utah School of Medicine, Division of Pediatric Neurosurgery, Primary Children's Medical Center, Salt Lake City, Utah
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Cranial osteosarcoma is very rare in children, rendering the development of optimal treatment algorithms challenging. The authors present 3 cases of pediatric cranial osteosarcoma: a primary calvarial tumor, a cranial metastasis, and a primary osteosarcoma of the cranial base. A review of the literature demonstrates significant variation in the management of cranial osteosarcomas and the outcome for patients with these tumors. This series and literature review is presented to improve the understanding of pediatric cranial osteosarcoma and to reinforce the importance of maximal resection in optimizing outcome.

Abbreviation used in this paper:

PEEK = polyetheretherketone.

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  • 1

    Ahmadi J, , Hinton DR, , Segall HD, & Couldwell WT: Surgical implications of magnetic resonance-enhanced dura. Neurosurgery 35:370377, 1994

    • Search Google Scholar
    • Export Citation
  • 2

    Arana E, , Martí-Bonmatí L, , Ricart V, & Pérez-Ebrí M: Dural enhancement with primary calvarial lesions. Neuroradiology 46:900905, 2004

    • Search Google Scholar
    • Export Citation
  • 3

    Ashkan K, , Pollock J, , D'Arrigo C, & Kitchen ND: Intracranial osteosarcomas: report of four cases and review of the literature. J Neurooncol 40:8796, 1998

    • Search Google Scholar
    • Export Citation
  • 4

    Benson JE, , Goske M, , Han JS, , Brodkey JS, & Yoon YS: Primary osteogenic sarcoma of the calvaria. AJNR Am J Neuroradiol 5:810813, 1984

  • 5

    Bose B: Primary osteogenic sarcoma of the skull. Surg Neurol 58:234240, 2002

  • 6

    Cabraja M, , Klein M, & Lehmann TN: Long-term results following titanium cranioplasty of large skull defects. Neurosurg Focus 26:6 E10, 2009

  • 7

    Caron AS, , Hajdu SI, & Strong EW: Osteogenic sarcoma of the facial and cranial bones. A review of forty-three cases. Am J Surg 122:719725, 1971

    • Search Google Scholar
    • Export Citation
  • 8

    Casentini L, , Visonà A, , Colombo F, , Pansa VS, , Pozza F, & Benedetti A: Osteogenic osteosarcoma of the calvaria following radiotherapy for cerebellar astrocytoma: report of a case in childhood. Tumori 71:391396, 1985

    • Search Google Scholar
    • Export Citation
  • 9

    Chander B, , Ralte AM, , Dahiya S, , Sharma MC, , Mahapatra AK, & Sharma AK, et al.: Primary osteosarcoma of the skull. A report of 3 cases. J Neurosurg Sci 47:177181, 2003

    • Search Google Scholar
    • Export Citation
  • 10

    Chandler CL, , Uttley D, , Archer DJ, & MacVicar D: Imaging after titanium cranioplasty. Br J Neurosurg 8:409414, 1994

  • 11

    Chang CS, , Bergeron L, , Liao CC, , Liao HT, , Chang CN, & Chen PK, et al.: Craniofacial reconstruction of primary osteogenic sarcoma of the skull. J Plast Reconstr Aesthet Surg 63:12651268, 2010

    • Search Google Scholar
    • Export Citation
  • 12

    Chennupati SK, , Norris R, , Dunham B, & Kazahaya K: Osteosarcoma of the skull base: case report and review of literature. Int J Pediatr Otorhinolaryngol 72:115119, 2008

    • Search Google Scholar
    • Export Citation
  • 13

    Cho DY, , Liau WR, , Lee WY, , Liu JT, , Chiu CL, & Sheu PC: Preliminary experience using a polyetheretherketone (PEEK) cage in the treatment of cervical disc disease. Neurosurgery 51:13431350, 2002

    • Search Google Scholar
    • Export Citation
  • 14

    Clark JL, , Unni KK, , Dahlin DC, & Devine KD: Osteosarcoma of the jaw. Cancer 51:23112316, 1983

  • 15

    Daw NC, , Mahmoud HH, , Meyer WH, , Jenkins JJ, , Kaste SC, & Poquette CA, et al.: Bone sarcomas of the head and neck in children: the St Jude Children's Research Hospital experience. Cancer 88:21722180, 2000

    • Search Google Scholar
    • Export Citation
  • 16

    Debnam JM, , Guha-Thakurta N, , Mahfouz YMM, , Garden AS, , Benjamin RS, & Sturgis EM, et al.: Radiation-associated head and neck sarcomas: spectrum of imaging findings. Oral Oncol 48:155161, 2012

    • Search Google Scholar
    • Export Citation
  • 17

    DeLaney TF, , Chen GT, , Mauceri TC, , Munro JJ, , Hornicek FJ, & Pedlow FX, et al.: Intraoperative dural irradiation by customized 192iridium and 90yttrium brachytherapy plaques. Int J Radiat Oncol Biol Phys 57:239245, 2003

    • Search Google Scholar
    • Export Citation
  • 18

    Ellison DA, , Silverman JF, , Strausbach PS, & Joshi VV: Fine-needle aspiration of chondroblastic osteosarcoma of the skull: report of a case in an 11-year-old girl. Diagn Cytopathol 14:5155, 1996

    • Search Google Scholar
    • Export Citation
  • 19

    Federman N, , Bernthal N, , Eilber FC, & Tap WD: The multidisciplinary management of osteosarcoma. Curr Treat Options Oncol 10:8293, 2009

  • 20

    Folkert MR, , Bilsky MH, , Cohen GN, , Zaider M, , Dauer LT, & Cox BW, et al.: Intraoperative 32P high-dose rate brachytherapy of the dura for recurrent primary and metastatic intracranial and spinal tumors. Neurosurgery 71:10031011, 2012

    • Search Google Scholar
    • Export Citation
  • 21

    Fuchs B, & Pritchard DJ: Etiology of osteosarcoma. Clin Orthop Relat Res 397 4052, 2002

  • 22

    Gadwal SR, , Gannon FH, , Fanburg-Smith JC, , Becoskie EM, & Thompson LD: Primary osteosarcoma of the head and neck in pediatric patients: a clinicopathologic study of 22 cases with a review of the literature. Cancer 91:598605, 2001

    • Search Google Scholar
    • Export Citation
  • 23

    Gangadhar K, & Santhosh D: Radiopathological evaluation of primary malignant skull tumors: a review. Clin Neurol Neurosurg 114:833839, 2012

    • Search Google Scholar
    • Export Citation
  • 24

    Garland LH: Osteogenic sarcoma of the skull. Radiology 45:4548, 1945

  • 25

    Gibson SE, & Prayson RA: Primary skull lesions in the pediatric population: a 25-year experience. Arch Pathol Lab Med 131:761766, 2007

  • 26

    Giuliano AE, , Feig S, & Eilber FR: Changing metastatic patterns of osteosarcoma. Cancer 54:21602164, 1984

  • 27

    Goodman MA, & McMaster JH: Primary osteosarcoma of the skull. Clin Orthop Relat Res 120 110114, 1976

  • 28

    Goorin AM, , Schwartzentruber DJ, , Devidas M, , Gebhardt MC, , Ayala AG, & Harris MB, et al.: Presurgical chemotherapy compared with immediate surgery and adjuvant chemotherapy for nonmetastatic osteosarcoma: Pediatric Oncology Group Study POG-8651. J Clin Oncol 21:15741580, 2003

    • Search Google Scholar
    • Export Citation
  • 29

    Gorlick R, & Khanna C: Osteosarcoma. J Bone Miner Res 25:683691, 2010

  • 30

    Guadagnolo BA, , Zagars GK, , Raymond AK, , Benjamin RS, & Sturgis EM: Osteosarcoma of the jaw/craniofacial region: outcomes after multimodality treatment. Cancer 115:32623270, 2009

    • Search Google Scholar
    • Export Citation
  • 31

    Ha PK, , Eisele DW, , Frassica FJ, , Zahurak ML, & McCarthy EF: Osteosarcoma of the head and neck: a review of the Johns Hopkins experience. Laryngoscope 109:964969, 1999

    • Search Google Scholar
    • Export Citation
  • 32

    Haque F, , Fazal ST, , Ahmad SA, , Abbas SZ, & Naseem S: Primary osteosarcoma of the skull. Australas Radiol 50:6365, 2006

  • 33

    Huvos AG, , Sundaresan N, , Bretsky SS, & Butler A: Osteogenic sarcoma of the skull. A clinicopathologic study of 19 patients. Cancer 56:12141221, 1985

    • Search Google Scholar
    • Export Citation
  • 34

    Inwards CY, & Unni KK: Classification and grading of bone sarcomas. Hematol Oncol Clin North Am 9:545569, 1995

  • 35

    Jasnau S, , Meyer U, , Potratz J, , Jundt G, , Kevric M, & Joos UK, et al.: Craniofacial osteosarcoma Experience of the cooperative German-Austrian-Swiss osteosarcoma study group. Oral Oncol 44:286294, 2008

    • Search Google Scholar
    • Export Citation
  • 36

    Jeffree GM, , Price CH, & Sissons HA: The metastatic patterns of osteosarcoma. Br J Cancer 32:87107, 1975

  • 37

    Kanazawa R, , Yoshida D, , Takahashi H, , Matsumoto K, & Teramoto A: Osteosarcoma arising from the skull—case report. Neurol Med Chir (Tokyo) 43:8891, 2003

    • Search Google Scholar
    • Export Citation
  • 38

    Kassir RR, , Rassekh CH, , Kinsella JB, , Segas J, , Carrau RL, & Hokanson JA: Osteosarcoma of the head and neck: meta-analysis of nonrandomized studies. Laryngoscope 107:5661, 1997

    • Search Google Scholar
    • Export Citation
  • 39

    Kellie SJ, , Hutchison RE, , Robertson JT, & Pratt CB: Successful treatment of a radiation-associated extradural osteosarcoma with chemotherapy in an adolescent girl. Med Pediatr Oncol 17:514519, 1989

    • Search Google Scholar
    • Export Citation
  • 40

    Kim SJ, , Choi JA, , Lee SH, , Choi JY, , Hong SH, & Chung HW, et al.: Imaging findings of extrapulmonary metastases of osteosarcoma. Clin Imaging 28:291300, 2004

    • Search Google Scholar
    • Export Citation
  • 41

    Kirby EJ, , Zhou HH, & Morales L Jr: Primary pediatric osteosarcoma of the skull. J Craniofac Surg 22:23992405, 2011

  • 42

    Kornreich L, , Grunebaum M, , Ziv N, & Cohen Y: Osteogenic sarcoma of the calvarium in children: CT manifestations. Neuroradiology 30:439441, 1988

    • Search Google Scholar
    • Export Citation
  • 43

    Lee MJ, , Kim S, , Lee SA, , Song HT, , Huh YM, & Kim DH, et al.: Overcoming artifacts from metallic orthopedic implants at high-field-strength MR imaging and multi-detector CT. Radiographics 27:791803, 2007

    • Search Google Scholar
    • Export Citation
  • 44

    Lin PY, , Chen WM, , Hsieh YL, , Chen WYK, & Chen TH: Orbital metastatic osteosarcoma. J Chin Med Assoc 68:286289, 2005

  • 45

    Mark RJ, , Sercarz JA, , Tran L, , Dodd LG, , Selch M, & Calcaterra TC: Osteogenic sarcoma of the head and neck. The UCLA experience. Arch Otolaryngol Head Neck Surg 117:761766, 1991

    • Search Google Scholar
    • Export Citation
  • 46

    Meel R, , Thulkar S, , Sharma MC, , Jagadesan P, , Mohanti BK, & Sharma SC, et al.: Childhood osteosarcoma of greater wing of sphenoid: case report and review of literature. J Pediatr Hematol Oncol 34:e59e62, 2012

    • Search Google Scholar
    • Export Citation
  • 47

    Mirabello L, , Troisi RJ, & Savage SA: International osteosarcoma incidence patterns in children and adolescents, middle ages and elderly persons. Int J Cancer 125:229234, 2009

    • Search Google Scholar
    • Export Citation
  • 48

    Mirabello L, , Troisi RJ, & Savage SA: Osteosarcoma incidence and survival rates from 1973 to 2004: data from the Surveillance, Epidemiology, and End Results Program. Cancer 115:15311543, 2009

    • Search Google Scholar
    • Export Citation
  • 49

    Niedeggen A, , Weis J, , Mertens R, , Röther J, & Bröcheler J: Unusually long survival time after resection and irradiation of a brain metastasis from osteosarcoma. Neurosurg Rev 13:247252, 1990

    • Search Google Scholar
    • Export Citation
  • 50

    Oakley GM, , Costa DJ, , Mitchell RB, & Sotelo C: Osteosarcoma of the skull base in a 15-year-old boy. Ear Nose Throat J 90:479480, 2011

  • 51

    Oda D, , Bavisotto LM, , Schmidt RA, , McNutt M, , Bruckner JD, & Conrad EU III, et al.: Head and neck osteosarcoma at the University of Washington. Head Neck 19:513523, 1997

    • Search Google Scholar
    • Export Citation
  • 52

    Ohno K, , Tsunoda A, , Shirakura S, , Takahashi N, & Kishimoto S: The approaches and outcomes of skull base surgery for pediatric sarcoma after initial therapy. Auris Nasus Larynx 38:208214, 2011

    • Search Google Scholar
    • Export Citation
  • 53

    Ottaviani G, & Jaffe N: The epidemiology of osteosarcoma. Cancer Treat Res 152:313, 2009

  • 54

    Patel AJ, , Rao VY, , Fox BD, , Suki D, , Wildrick DM, & Sawaya R, et al.: Radiation-induced osteosarcomas of the calvarium and skull base. Cancer 117:21202126, 2011

    • Search Google Scholar
    • Export Citation
  • 55

    Potepan P, , Luksch R, , Sozzi G, , Testi A, , Laffranchi A, & Danesini GM, et al.: Multifocal osteosarcoma as second tumor after childhood retinoblastoma. Skeletal Radiol 28:415421, 1999

    • Search Google Scholar
    • Export Citation
  • 56

    Reddy DR, , Swami NR, , Qureshi MA, , Rammohan S, , Rao BH, & Krishna RV: Primary osteogenic sarcoma involving skull (a case report). Neurol India 21:141142, 1973

    • Search Google Scholar
    • Export Citation
  • 57

    Ritter J, & Bielack SS: Osteosarcoma. Ann Oncol 21:Suppl 7 vii320vii325, 2010

  • 58

    Salvati M, , Ciappetta P, , Capone R, , Santoro A, , Raguso M, & Raco A: Osteosarcoma of the skull in a child: case report and review of the literature. Childs Nerv Syst 9:437439, 1993

    • Search Google Scholar
    • Export Citation
  • 59

    Salvati M, , Ciappetta P, & Raco A: Osteosarcomas of the skull. Clinical remarks on 19 cases. Cancer 71:22102216, 1993

  • 60

    Schwarz R, , Bruland O, , Cassoni A, , Schomberg P, & Bielack S, The role of radiotherapy in oseosarcoma. Jaffe N, , Bruland O, & Bielack S: Pediatric and Adolescent Osteosarcoma New York, Springer, 2010. 147164

    • Search Google Scholar
    • Export Citation
  • 61

    Shinoda J, , Kimura T, , Funakoshi T, , Iwata H, , Tange K, & Kasai C, et al.: Primary osteosarcoma of the skull—a case report and review of the literature. J Neurooncol 17:8188, 1993

    • Search Google Scholar
    • Export Citation
  • 62

    Shramek JK, , Kassner EG, & White SS: MR appearance of osteogenic sarcoma of the calvaria. AJR Am J Roentgenol 158:661662, 1992

  • 63

    Smeele LE, , Kostense PJ, , van der Waal I, & Snow GB: Effect of chemotherapy on survival of craniofacial osteosarcoma: a systematic review of 201 patients. J Clin Oncol 15:363367, 1997

    • Search Google Scholar
    • Export Citation
  • 64

    Sundaresan N, , Huvos AG, , Rosen G, & Galicich JH: Combined-modality treatment of osteogenic sarcoma of the skull. J Neurosurg 63:562567, 1985

    • Search Google Scholar
    • Export Citation
  • 65

    Vege DS, , Borges AM, , Aggrawal K, , Balasubramaniam G, , Parikh DM, & Bhaser B: Osteosarcoma of the craniofacial bones. A clinico-pathological study. J Craniomaxillofac Surg 19:9093, 1991

    • Search Google Scholar
    • Export Citation
  • 66

    Wang YC, , Shih CJ, , Leu FJ, & Tu YC: Primary osteogenic sarcoma of the skull: case report. Neurosurgery 9:307310, 1981

  • 67

    Winkler K, , Beron G, , Kotz R, , Salzer-Kuntschik M, , Beck J, & Beck W, et al.: Neoadjuvant chemotherapy for osteogenic sarcoma: results of a Cooperative German/Austrian study. J Clin Oncol 2:617624, 1984

    • Search Google Scholar
    • Export Citation

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