Pallidal deep brain stimulation for dystonia: a case series

Clinical article

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  • 1 Department of Neurology, Brigham and Women's Hospital; and
  • 2 Departments of Neurology and
  • 3 Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts
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Object

Pallidal deep brain stimulation (DBS) is a treatment option for those with early-onset dystonia. However, there are limited data on long-term outcome and treatment complications. The authors report on the short- and long-term effects of pallidal DBS in a cohort of patients with early-onset dystonia.

Methods

Fourteen consecutive pediatric patients with early-onset dystonia were systematically evaluated and treated. The duration of follow-up ranged from 16 to 84 months.

Results

There were no immediate postoperative complications. At last follow-up, 12 of the 14 patients displayed a significant decline in the Burke-Fahn-Marsden Dystonia Rating Scale motor subscale score, with an average decrease of 62% ± 8.4%. The most common hardware complication was lead fracture (14.3%).

Conclusions

These data provide further evidence that DBS is a safe and effective treatment for those with earlyonset dystonia.

Abbreviations used in this paper:BFMDRS = Burke-Fahn-Marsden Dystonia Rating Scale; DBS = deep brain stimulation; GPi = globus pallidus interna; IPG = implantable pulse generator.

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Contributor Notes

Address correspondence to: Nutan Sharma, M.D., Ph.D., 149 13th St., Rm. 6407, Charlestown, MA 02129. email: nsharma@partners.org.

Please include this information when citing this paper: published online October 4, 2013; DOI: 10.3171/2013.8.PEDS13134.

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