A variety of surgical strategies are used to correct sagittal craniosynostosis. There is increasing experience with the use of endoscope-assisted techniques, although there is no consensus regarding the optimal technique. Pancraniosynostosis occurring after the surgical repair of single-suture craniosynostosis is an unusual complication. The authors describe the case of a nonsyndromic patient who underwent an endoscope-assisted strip craniectomy with the subsequent use of a helmet orthosis for correction of an isolated sagittal suture craniosynostosis. The patient's early postoperative course was uneventful. Pancraniosynostosis subsequently developed, requiring much more extensive surgical correction. Awareness of this potential complication is necessary to ensure its recognition and appropriate management.