Intracranial aneurysm following radiation therapy during childhood for a brain tumor

Case report and review of the literature

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✓ Ionizing radiation therapy is associated with pathological vascular changes in intracranial vessels, most commonly in the form of vessel thrombosis and occlusion. The development of an intracranial aneurysm following such therapy, however, is far less common. In this report the authors describe a 24-year-old man in whom a distal middle cerebral artery aneurysm developed 15 years after radiotherapy, which was given as adjuvant treatment following resection of a medulloblastoma. The patient underwent a craniotomy for microsurgical trapping of the aneurysm and was discharged without any neurological deficit. This case serves to remind clinicians of the possibility, albeit rare, that intracranial aneurysms may form following cranial radiotherapy.

Abbreviations used in this paper:ACA = anterior cerebral artery; BA = basilar artery; CT = computed tomography; EC = endothelial cell; ICA = internal carotid artery; MCA = middle cerebral artery; MR = magnetic resonance; SAH = subarachnoid hemorrhage.
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Contributor Notes

Address reprint requests to: Richard E. Clatterbuck, M.D., Ph.D., Department of Neurosurgery, The Johns Hopkins School of Medicine, 600 North Wolfe Street, Meyer 8-181, Baltimore, Maryland 21287. email: rclatte1@jhmi.edu.

© AANS, except where prohibited by US copyright law.

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