Multifocal meningioangiomatosis in a 3-year-old patient

Case report

Restricted access

Meningioangiomatosis consists of benign hamartomatous lesions of the brain and the leptomeninges, which typically present with seizure. Management is predicated on resection and control of seizures with medication. Lesions are typically solitary. Multifocal meningioangiomatosis is extremely rare, with only 2 cases reported in adults and none in children. The authors report the first case, to their knowledge, of multifocal meningioangiomatosis in a child. This unique case highlights therapeutic challenges associated with these lesions and demonstrates that multifocality is possible in the pediatric population. This finding has implications for diagnosis and follow-up for children afflicted with these tumors.

Abbreviation used in this paper:NF2 = neurofibromatosis Type 2.
Article Information

Contributor Notes

Address correspondence to: Edward Smith, M.D., Department of Neurosurgery, Children's Hospital Boston, 300 Longwood Avenue, HU2, Boston, Massachusetts 02115. email: edward.smith@childrens.harvard.edu.Please include this information when citing this paper: published online September 28, 2012; DOI: 10.3171/2012.9.PEDS1224.

© AANS, except where prohibited by US copyright law.

Headings
References
  • 1

    Aizpuru RNQuencer RMNorenberg MAltman NSmirniotopoulos J: Meningioangiomatosis: clinical, radiologic, and histopathologic correlation. Radiology 179:8198211991

    • Search Google Scholar
    • Export Citation
  • 2

    Bassoe PNuzum F: Report of a case of central and peripheral neurofibromatosis. J Nerv Ment Dis 42:7857961915

  • 3

    Blumenthal DBerho MBloomfield SSchochet SS JrKaufman HH: Childhood meningioma associated with meningioangiomatosis. Case report. J Neurosurg 78:2872891993

    • Search Google Scholar
    • Export Citation
  • 4

    Deb PGupta ASharma MCGaikwad SSingh VPSarkar C: Meningioangiomatosis with meningioma: an uncommon association of a rare entity—report of a case and review of the literature. Childs Nerv Syst 22:78832006

    • Search Google Scholar
    • Export Citation
  • 5

    Fedi MKalnins RMShuey NFitt GJNewton MMitchell LA: Cystic meningioangiomatosis in neurofibromatosis type 2: an MRI-pathological study. Br J Radiol 82:e129e1322009

    • Search Google Scholar
    • Export Citation
  • 6

    Fujimoto KNikaidoh YYuasa TNagata KIda YFujioka M: Meningioangiomatosis not associated with von Recklinghausen's disease—case report. Neurol Med Chir (Tokyo) 33:6516551993

    • Search Google Scholar
    • Export Citation
  • 7

    Jallo GIKothbauer KMehta VAbbott REpstein F: Meningioangiomatosis without neurofibromatosis: a clinical analysis. J Neurosurg 103:4 Suppl3193242005

    • Search Google Scholar
    • Export Citation
  • 8

    Jorge CLNagahashi-Marie SKPedreira CCRosemberg SValério RMValente KD: Clinical characteristics and surgical outcome of patients with temporal lobe tumors and epilepsy. Arq Neuropsiquiatr 58:100210082000

    • Search Google Scholar
    • Export Citation
  • 9

    Kim NRCho SJSuh YL: Allelic loss on chromosomes 1p32, 9p21, 13q14, 16q22, 17p, and 22q12 in meningiomas associated with meningioangiomatosis and pure meningioangiomatosis. J Neurooncol 94:4254302009

    • Search Google Scholar
    • Export Citation
  • 10

    Kim NRChoe GShin SHWang KCCho BKChoi KS: Childhood meningiomas associated with meningioangiomatosis: report of five cases and literature review. Neuropathol Appl Neurobiol 28:48562002

    • Search Google Scholar
    • Export Citation
  • 11

    Kim SHYoon SHKim JH: A case of infantile meningioangiomatosis with a separate cyst. J Korean Neurosurg Soc 46:2522562009

  • 12

    Kobayashi HIshii NMurata JSaito HKubota KCNagashima K: Cystic meningioangiomatosis. Pediatr Neurosurg 42:3203242006

  • 13

    Liu SSJohnson PCSonntag VK: Meningioangiomatosis: a case report. Surg Neurol 31:3763801989

  • 14

    López JIEreño COleaga LAreitio E: Meningioangiomatosis and oligodendroglioma in a 15-year-old boy. Arch Pathol Lab Med 120:5875901996

    • Search Google Scholar
    • Export Citation
  • 15

    Mut MSöylemezoğlu FFirat MMPalaoğlu S: Intraparenchymal meningioma originating from underlying meningioangiomatosis. Case report and review of the literature. J Neurosurg 92:7067102000

    • Search Google Scholar
    • Export Citation
  • 16

    Omeis IHillard VHBraun ABenzil DLMurali RHarter DH: Meningioangiomatosis associated with neurofibromatosis: report of 2 cases in a single family and review of the literature. Surg Neurol 65:5956032006

    • Search Google Scholar
    • Export Citation
  • 17

    Park MSSuh DCChoi WSLee SYKang GH: Multifocal meningioangiomatosis: a report of two cases. AJNR Am J Neuroradiol 20:6776801999

    • Search Google Scholar
    • Export Citation
  • 18

    Saad AFolkerth RPoussaint TSmith ELigon K: Meningioangiomatosis associated with meningioma: a case report. Acta Cytol 53:93972009

    • Search Google Scholar
    • Export Citation
  • 19

    Stemmer-Rachamimov AOHorgan MATaratuto ALMunoz DGSmith TWFrosch MP: Meningioangiomatosis is associated with neurofibromatosis 2 but not with somatic alterations of the NF2 gene. J Neuropathol Exp Neurol 56:4854891997

    • Search Google Scholar
    • Export Citation
  • 20

    Tacconi LThom MSymon L: Cerebral meningioangiomatosis: case report. Surg Neurol 48:2552601997

  • 21

    Takeshima YAmatya VJNakayori FNakano TSugiyama KInai K: Meningioangiomatosis occurring in a young male without neurofibromatosis: with special reference to its histogenesis and loss of heterozygosity in the NF2 gene region. Am J Surg Pathol 26:1251292002

    • Search Google Scholar
    • Export Citation
  • 22

    Tien RDOsumi AOakes JWMadden JFBurger PC: Meningioangiomatosis: CT and MR findings. J Comput Assist Tomogr 16:3613651992

  • 23

    Wang YGao XYao ZWChen HZhu JJWang SX: Histopathological study of five cases with sporadic meningioangiomatosis. Neuropathology 26:2492562006

    • Search Google Scholar
    • Export Citation
  • 24

    Whiting DMAwad IAMiles JChou SSLüders H: Intractable complex partial seizures associated with occult temporal lobe encephalocele and meningoangiomatosis: a case report. Surg Neurol 34:3183221990

    • Search Google Scholar
    • Export Citation
  • 25

    Wiebe SMunoz DGSmith SLee DH: Meningioangiomatosis. A comprehensive analysis of clinical and laboratory features. Brain 122:7097261999

    • Search Google Scholar
    • Export Citation
  • 26

    Wilson DDempsey RJClark DB: Meningioma developing from underlying meningioangiomatosis. J Neuropathol Exp Neurol 50:3711991. (Abstract)

    • Search Google Scholar
    • Export Citation
TrendMD
Metrics

Metrics

All Time Past Year Past 30 Days
Abstract Views 128 128 6
Full Text Views 53 51 0
PDF Downloads 126 120 0
EPUB Downloads 0 0 0
PubMed
Google Scholar