Primary intracranial β-human chorionic gonadotropin–producing leiomyosarcoma in a 2-year-old immunocompetent child

Case report

Restricted access

The authors present a rare case of primary intracranial leiomyosarcoma (LMS) in a young, immunocompetent boy. The patient presented with an expanding right forehead mass. Diagnostic workup revealed multiple large intracranial tumors. The largest mass was resected, and pathological analysis revealed LMS. Given the poor prognosis of this tumor, the family declined further care, and the child died 3 months later. Primary LMSs are extremely rare tumors in the pediatric population, especially in patients who are not immunocompromised.

Abbreviations used in this paper:AFP = alpha-fetoprotein; β-hCG = β human chorionic gonadotropin; CA125 = cancer antigen 125; CEA = carcinoembryonic antigen; EBV = Epstein-Barr virus; LMS = leiomyosarcoma.
Article Information

Contributor Notes

Address correspondence to: Paul M. Arnold, M.D., Department of Neurosurgery, Mail Stop 3021, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, Kansas 66160. email: parnold@kumc.edu.Please include this information when citing this paper: published online June 29, 2012; DOI: 10.3171/2012.4.PEDS1216.
Headings
References
  • 1

    Amant FCoosemans ADebiec-Rychter MTimmerman DVergote I: Clinical management of uterine sarcomas. Lancet Oncol 10:118811982009

    • Search Google Scholar
    • Export Citation
  • 2

    Anderson WRCameron JDTsai SH: Primary intracranial leiomyosarcoma. Case report with ultrastructural study. J Neurosurg 53:4014051980

    • Search Google Scholar
    • Export Citation
  • 3

    Asai AYamada HMurata SMatsuno ATsutsumi KTakemura T: Primary leiomyosarcoma of the dura mater. Case report. J Neurosurg 68:3083111988

    • Search Google Scholar
    • Export Citation
  • 4

    Bejjani GKStopak BSchwartz ASanti R: Primary dural leiomyosarcoma in a patient infected with human immunodeficiency virus: case report. Neurosurgery 44:1992021999

    • Search Google Scholar
    • Export Citation
  • 5

    Blumenthal DTRaizer JJRosenblum MKBilsky MHHariharan SAbrey LE: Primary intracranial neoplasms in patients with HIV. Neurology 52:164816511999

    • Search Google Scholar
    • Export Citation
  • 6

    Brown HGBurger PCOlivi ASills AKBarditch-Crovo PALee RR: Intracranial leiomyosarcoma in a patient with AIDS. Neuroradiology 41:35391999

    • Search Google Scholar
    • Export Citation
  • 7

    Buff BL JrSchick RMNorregaard T: Meningeal metastasis of leiomyosarcoma mimicking meningioma: CT and MR findings. J Comput Assist Tomogr 15:1661671991

    • Search Google Scholar
    • Export Citation
  • 8

    Citow JSKranzler L: Multicentric intracranial smooth-muscle tumor in a woman with human immunodeficiency virus. Case report. J Neurosurg 93:7017032000

    • Search Google Scholar
    • Export Citation
  • 9

    Eckhardt BPBrandner SZollikofer CLWentz KU: Primary cerebral leiomyosarcoma in a child. Pediatr Radiol 34:4954982004

  • 10

    Espat NJBilsky MLewis JJLeung DBrennan MF: Soft tissue sarcoma brain metastases. Prevalence in a cohort of 3829 patients. Cancer 94:270627112002

    • Search Google Scholar
    • Export Citation
  • 11

    Fujimoto YHirato JWakayama AYoshimine T: Primary intracranial leiomyosarcoma in an immunocompetent patient: case report. J Neurooncol 103:7857902011

    • Search Google Scholar
    • Export Citation
  • 12

    Hussain SNanda AFowler MAmpil FLBurton GV: Primary intracranial leiomyosarcoma: report of a case and review of the literature. Sarcoma 2006:521402006

    • Search Google Scholar
    • Export Citation
  • 13

    Jain ASajeevan KVBabu KGLakshmaiah KC: Chemotherapy in adult soft tissue sarcoma. Indian J Cancer 46:2742872009

  • 14

    Jhas SHenriques LHawkins CBouffet ERutka JT: An intracranial leiomyosarcoma in a child with neurofibromatosis type 1. Can J Neurol Sci 36:4914952009

    • Search Google Scholar
    • Export Citation
  • 15

    Lee TTPage LK: Primary cerebral leiomyosarcoma. Clin Neurol Neurosurg 99:2102121997

  • 16

    Lerdlum SLalitanantpong SNumkarunarunrote NChaowanapanja PSuankratay CShuangshoti S: MR imaging of CNS leiomyosarcoma in AIDS patients. J Med Assoc Thai 87:Suppl 2S152S1602004

    • Search Google Scholar
    • Export Citation
  • 17

    Li NY: [Primary leiomyosarcoma of the pineal gland—a case report.]. Zhonghua Zhong Liu Za Zhi 9:4634641987. (Chinese)

  • 18

    Liang SStone GChalas EPearl MCallan FZheng W: A high-grade uterine leiomyosarcoma with human chorionic gonadotropin production. Int J Gynecol Pathol 25:2572612006

    • Search Google Scholar
    • Export Citation
  • 19

    Litofsky NSPihan GCorvi FSmith TW: Intracranial leiomyosarcoma: a neuro-oncological consequence of acquired immunodeficiency syndrome. J Neurooncol 40:1791831998

    • Search Google Scholar
    • Export Citation
  • 20

    Louis DNRichardson EP JrDickersin GRPetrucci DARosenberg AEOjemann RG: Primary intracranial leiomyosarcoma. Case report. J Neurosurg 71:2792821989

    • Search Google Scholar
    • Export Citation
  • 21

    Mathieson CSSt George EJStewart WSastry JJamal S: Primary intracranial leiomyosarcoma: a case report and review of the literature. Childs Nerv Syst 25:101310172009

    • Search Google Scholar
    • Export Citation
  • 22

    Murakami NMorioka TNishio SMatsukado KInamura TFukui M: [Radiation-induced leiomyosarcoma of the dura mater: a case report.]. No Shinkei Geka 25:104910531997. (Jpn)

    • Search Google Scholar
    • Export Citation
  • 23

    Niwa JHashi KMinase T: Radiation induced intracranial leiomyosarcoma: its histopathological features. Acta Neurochir (Wien) 138:147014711996

    • Search Google Scholar
    • Export Citation
  • 24

    Paulus WSlowik FJellinger K: Primary intracranial sarcomas: histopathological features of 19 cases. Histopathology 18:3954021991

    • Search Google Scholar
    • Export Citation
  • 25

    Polšek DJagatic TCepanec MHof PRSimić G: Recent developments in neuropathology of autism spectrum disorders. Transl Neurosci 2:2562642011

    • Search Google Scholar
    • Export Citation
  • 26

    Sivendran SVidal CIBarginear MF: Primary intracranial leiomyosarcoma in an HIV-infected patient. Int J Clin Oncol 16:63662011

  • 27

    Skullerud KStenwig AEBrandtzaeg PNesland JMKerty ELangmoen I: Intracranial primary leiomyosarcoma arising in a teratoma of the pineal area. Clin Neuropathol 14:2452481995

    • Search Google Scholar
    • Export Citation
  • 28

    Suankratay CShuangshoti SMutirangura APrasanthai VLerdlum SShuangshoti S: Epstein-Barr virus infection-associated smooth-muscle tumors in patients with AIDS. Clin Infect Dis 40:152115282005

    • Search Google Scholar
    • Export Citation
TrendMD
Metrics

Metrics

All Time Past Year Past 30 Days
Abstract Views 170 122 7
Full Text Views 45 13 0
PDF Downloads 97 40 0
EPUB Downloads 0 0 0
PubMed
Google Scholar