Desmoplastic infantile ganglioglioma with a malignant course

Case report

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✓Desmoplastic infantile gangliogliomas (DIGs) are rare supratentorial tumors that arise in infancy. Despite the large size of these lesions, the prognosis is generally considered favorable after gross-total resection (GTR); however, in incidental cases tumor progression has been described. The authors report on a child harboring a DIG with a high-grade primitive cell population and glial differentiation. The progressive clinical course was determined by this cell component in spite of GTR and adjuvant chemotherapy. The significance of the presence of a high-grade primitive tumor component in the context of DIG is discussed.

Abbreviations used in this paper: DIG = desmoplastic infantile ganglioglioma; GFAP = glial fibrillary acidic protein; GTR = gross-total resection; LI = labeling index; MR = magnetic resonance.
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Contributor Notes

Address correspondence to: Eelco W. Hoving, M.D., Ph.D., Department of Neurosurgery, University Medical Center Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands. email: e.w.hoving@nchir.umcg.nl.

© AANS, except where prohibited by US copyright law.

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