Cerebrospinal fluid volume depletion and its emerging clinical/imaging syndromes

Full access

Cerebrospinal fluid (CSF) volume depletion, due to CSF leakage or CSF shunt overdrainage, is typically indicated when patients present with orthostatic headaches, with or without several other symptoms: neck or interscapular pain, nausea, emesis, diplopia, changes in hearing, visual blurring, facial numbness or weakness, and radicular upper-limb symptoms. Cerebrospinal fluid pressures typically are quite low and head magnetic resonance images typically reveal diffuse pachy-meningeal gadolinium enhancement, with or without evidence of sagging of the brain and less frequently with subdural fluid collections, enlarged cerebral venous sinuses or pituitary gland or decreased ventricular size.

Magnetic resonance imaging has revolutionized detection of spontaneous CSF leaks, leading to identification of far more cases and recognition of several clinical/imaging forms of presentation of the disorder. These forms, which are different from the “typical” presentation, include a group with consistently normal CSF pressures (normal pressure), another group without abnormal meningeal enhancement (normal meninges), and a group without headache (acephalic). Each of these forms can be seen in a setting of documented and ongoing CSF volume depletion. Awareness of CSF volume depletion is increasing, and its clinical and imaging spectrum is broadening.

Abbreviations used in this paper:CSF = cerebrospinal fluid; CT = computerized tomography; MR = magnetic resonance.

Article Information

Address reprint requests to: Bahram Mokri, M.D., Department of Neurology, Mayo Clinic, 200 First Street, S.W., Rochester, Minnesota 55905.

© AANS, except where prohibited by US copyright law.

TrendMD

Metrics

Metrics

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 54 54 53
PDF Downloads 34 34 28
EPUB Downloads 0 0 0

PubMed

Google Scholar