The lateral lumbar interbody fusion (LLIF) technique was first described by Ozgur et al. in 2006 and uses a retroperitoneal, transpsoas approach to the disc space.1 This approach is used to treat many spinal conditions, including degenerative disc disease, stenosis, spondylolisthesis, scoliosis, and spinal instability. The LLIF technique offers several potential advantages over traditional posterior approaches, including reduced blood loss, lower postoperative pain, and shorter hospital stay.1–3 The LLIF technique has been reported for patients with adult spinal deformity, and is often combined with a posterior approach to achieve deformity correction and arthrodesis.4–6 Given the limited direct visualization during the minimally invasive LLIF procedure and the close proximity to the lumbosacral plexus, neuromonitoring and fluoroscopy have been used, which can result in significant exposure to radiation for the patient and surgeon.7,8
The use of computer-assisted 3D navigation (CaN) techniques for placement of pedicle screws and interbody cages has been reported to increase accuracy with reduced radiation exposure.8–16 Similarly, CaN has also been applied to the LLIF technique with appropriate accuracy and decreased need for fluoroscopy.13,17 The use of CaN for multiple-level LLIF in the treatment of patients with adult spinal deformity, however, is still relatively novel and has not been extensively studied.
In this study we retrospectively reviewed a cohort of patients undergoing multiple-level LLIF with CaN for spinal deformity. We evaluated intraoperative and perioperative complications as they related to the CaN LLIF approach. We hypothesized that navigated placement of interbody cages is safe and feasible in this patient population.
Methods
Data Collection
Patients who underwent a deformity correction surgery at the University of Michigan between 2014 and 2020 were identified. We defined spinal deformity as sagittal vertical axis (SVA) > 5 cm, pelvic incidence–lumbar lordosis (PI-LL) mismatch > 10°, pelvic tilt (PT) > 20°, or coronal thoracolumbar curve > 30°. All patients were older than 18 years and had 2 or more navigated lateral interbody cages placed with subsequent posterior instrumentation. Data collected included age, gender, body mass index (BMI), race/ethnicity, osteopenia/osteoporosis status, smoking status, clinical symptoms, duration of symptoms, conservative management, radiographic parameters including SVA, coronal Cobb angle, PT, PI, LL, procedure characteristics including number of lateral interbody cages placed, number of posterior fusion levels, open versus percutaneous posterior screw placement, graft type, average blood loss, average surgical time, number of unplanned intraoperative CT image acquisitions, intraoperative complications, complications specifically related to navigation, postoperative complications, and length of stay. We excluded patients in whom CaN cage placement was not used, and who had nondegenerative causes of deformity such as deformity secondary to osteomyelitis or metastatic tumors to the spine. Patients were seen in the clinic by the primary surgeon at a minimum of 1 month after surgery.
Standing scoliosis radiographs were obtained for all patients pre- and postoperatively. Radiographic parameters were measured using the PACS (picture archiving and communication systems) built-in measuring tools. The Cobb angle was measured using the major thoracolumbar curve identifying the upper and lower end vertebrae. The SVA was measured using the plumb line from the midpoint of C7 and the distance from the posterior-superior corner of the sacrum. The pelvic incidence was measured using a line from the femoral head and a perpendicular line from the midpoint of the S1 superior endplate. The PT was measured using a line from the femoral head and a line from the midpoint of the S1 superior endplate down to the bottom of the radiograph. Lumbar lordosis was measured by the angulation from the superior endplate of L1 to the superior endplate of S1.
Intraoperative CaN-related complications were separated into the LLIF stage and the posterior stage and defined as any CaN inaccuracy leading to misplaced interbody cage, breach of pedicle screw, or unplanned intraoperative CT acquisition. Neurological complications related to the LLIF approach were defined as transient (lasting < 1 month) or persistent (still present after 1 month) weakness or numbness in the lower extremity on the same side as surgery. Medical postoperative complications were also assessed.
Retrospective database analysis produced a list of 65 potentially eligible patients. Two patients did not undergo CaN interbody placement and were excluded from the study. An additional 4 patients did not have adequate follow-up and were also excluded. The study was approved by the University of Michigan Institutional Review Board.
Surgical Technique
This technique has previously been described in detail.1,17 Briefly, navigated placement of interbody cages from a lateral approach involved placing the patient in a lateral decubitus position on a flat radiolucent operating room table. A flank roll was placed to increase the interval between the lower end of the rib cage and iliac crest. An iliac pin with navigation reference frame was placed. The intraoperative CT fluoroscopy unit was brought into the field and 3D imaging of the spine was obtained for navigation purposes. Intraoperative navigation was used to plan the skin incision, assist with the approach and retractor placement, disc preparation, and placement of the interbody cage. Fluoroscopy was not typically used for skin marking or the approach for retractor placement, but was used sparingly to confirm cage positioning and to confirm navigation accuracy when needed. The most rostral–level LLIF was performed first, and proceeded sequentially caudally toward the navigation frame, thus maintaining navigation accuracy. Posterior instrumentation was performed either on the same day or in a staged fashion. Multimodal neuromonitoring was used during the operation, with triggered electromyography during the approach through the psoas muscle. In addition, in cases in which there were anatomical constraints (e.g., iliac crest), an oblique approach that involved traversing the anterior margin of the psoas muscle was used.
Statistical Analysis
A univariate analysis was performed to analyze demographics and clinical characteristics in relation to complications. Age, gender, BMI, osteopenia/osteoporosis, smoking status, number of LLIF levels, number of posterior fusion levels, average surgical time, and average blood loss (independent variables) were used to predict intraoperative complications (dependent variable) in a binomial logistic regression analysis. Statistical analysis was performed using the SPSS statistical package software (version 26; IBM Corp.) and statistical significance was defined as a value of p < 0.05.
Results
A total of 59 patients were included in this study (Table 1). The mean age at the time of surgery was 66.3 years (range 42–83 years) and BMI was 27.6 kg/m2 (range 18–43 kg/m2). Thirty-four patients were female (57.6%), 24 were male (40.7%), and 1 was transgender male to female (1.7%). All patients presented with symptomatic kyphoscoliosis. The average coronal Cobb angle was 26.8° (range 3.6°–67.0°), SVA was 6.3 cm (range −2.3 to 14.7 cm), PI-LL mismatch was 17.5° (range −11.9° to 57.8°), LL was 38.8° degrees (range 3.7°–84.1° degrees), and PT was 23.7° (range 7.5°–47.6°).
Demographics in the study population of 59 patients with LLIF
Patient Variables | Value | Percentage | Range |
---|---|---|---|
Age (yrs) | 66.3 | 42–83 | |
BMI (kg/m2) | 27.6 | 18–43 | |
Gender | |||
Female | 34 | 57.6% | |
Male | 24 | 40.7% | |
Other | 1 | 1.7% | |
Race/ethnicity | |||
White/non-Hispanic | 56 | 94.9% | |
Black/non-Hispanic | 2 | 3.4% | |
Other/Hispanic | 1 | 1.7% | |
Osteopenia/osteoporosis | 28 | 47.5% | |
Smoker | 6 | 10.2% | |
Symptoms | |||
Back pain | 57 | 96.6% | |
Neurogenic bowel or bladder | 2 | 3.4% | |
Neurogenic claudication | 11 | 18.6% | |
Motor deficits | 21 | 35.6% | |
Radiculopathy | 54 | 91.5% | |
Myelopathy | 3 | 5.1% | |
Location of pain | |||
Back | 5 | 8.5% | |
Leg | 2 | 3.4% | |
Both | 52 | 88.1% | |
Duration of symptoms | |||
<3 mos | 1 | 1.7% | |
3–12 mos | 5 | 8.5% | |
>12 mos | 53 | 89.8% | |
Average coronal Cobb angle (°) | 26.8 | 3.6–67.0 | |
SVA (cm) | 6.3 | −2.3 to 14.7 | |
PI-LL mismatch (°) | 17.5 | −11.9 to 57.8 | |
LL (°) | 38.8 | 3.7–84.1 | |
PT (°) | 23.7 | 7.5–47.6 |
Unless otherwise indicated, values are expressed as the number of patients and percentage.
Back pain was the most common presenting symptom in a total of 57 patients (96.6%). Other neurological symptoms included 2 patients with neurogenic bowel or bladder (3.4%), 11 with neurogenic claudication (18.6%), 21 with lower-extremity weakness (35.6%), 54 with lower-extremity radiculopathy (91.5%), and 3 with myelopathy (5.1%) in which 1 patient had a previous anterior cervical fusion. Most patients presented with symptoms lasting longer than 12 months (53 patients, 89.8%). Conservative management had failed in all patients.
An average of 2.97 LLIF cages per patient were placed using CaN (range 2–5 cages), with a total of 175 cages placed (Table 2). Nineteen patients included supplementation with either transforaminal lumbar interbody fusion (TLIF; n = 16) or anterior lumbar interbody fusion (ALIF; n = 3). All 3 ALIFs were performed with the aid of an approach surgeon, with the patient lying lateral, and using an oblique trajectory. The average number of levels for posterior instrumentation was 5.78 (range 3–14 levels). The uppermost instrumented vertebrae ranged from T6 to L3 with the majority at T10 (13 patients), L1 (14 patients), L2 (15 patients), and L3 (11 patients). The lowermost instrumented vertebrae ranged from L3 to S2–alar–iliac with the majority at L5 (28 patients), S1 (6 patients), S1 with iliac screws (S1–iliac, 4 patients) and S2–alar–iliac (13 patients). Of the 23 patients in whom the posterior construct spanned L5–S1, 16 patients (70%) underwent L5–S1 interbody fusion using either a TLIF or ALIF technique at that level.
Operative characteristics in the study population of 59 patients with LLIF
Operative Variables | Value | Percentage | Range |
---|---|---|---|
No. of LLIF levels | 175 total | ||
2 | 19 | 32.2% | |
3 | 25 | 42.4% | |
4 | 13 | 22.0% | |
5 | 2 | 3.4% | |
TLIF | |||
L4–5 | 2 | 3.4% | |
L5–S1 | 14 | 23.7% | |
ALIF | |||
L4–5 | 1 | 1.7% | |
L5–S1 | 2 | 3.4% | |
No. of posterior fusion levels | |||
3 | 13 | 22.0% | |
4 | 14 | 23.7% | |
5 | 9 | 15.3% | |
6 | 4 | 6.8% | |
7 | 3 | 5.1% | |
8 | 1 | 1.7% | |
9 | 7 | 11.9% | |
10 | 6 | 10.2% | |
11 | 1 | 1.7% | |
14 | 1 | 1.7% | |
Uppermost instrumented vertebrae | |||
T6 | 1 | ||
T7 | 1 | ||
T9 | 1 | ||
T10 | 13 | ||
T11 | 2 | ||
T12 | 1 | ||
L1 | 14 | ||
L2 | 15 | ||
L3 | 11 | ||
Lowermost instrumented vertebrae | |||
L3 | 1 | ||
L4 | 7 | ||
L5 | 28 | ||
S1 | 6 | ||
S1–iliac | 4 | ||
S2–alar–iliac | 13 | ||
Posterior approach | |||
Same day | 36 | 61.0% | |
Staged | 23 | 39.0% | |
Graft | |||
Allograft | 37 | 62.7% | |
Autograft & allograft | 22 | 37.3% | |
Posterior instrumentation | |||
Open | 28 | 47.5% | |
Percutaneous | 28 | 47.5% | |
Percutaneous (robot) | 2 | 3.4% | |
Hybrid open–percutaneous | 1 | 1.7% | |
Length of stay (days) | 7.4 | 3–28 | |
Average surgical time (mins) | |||
Same day | 483.9 | 129–1089 | |
Staged (navigated LLIF) | 278.6 | 126–635 | |
Staged (posterior instrumentation) | 366.9 | 97–724 | |
Average estimated blood loss (mL) | |||
Same day | 668.7 | 20–3400 | |
Staged (navigated LLIF) | 99.1 | 20–345 | |
Staged (posterior instrumentation) | 883.0 | 15–3200 | |
Average coronal Cobb angle correction (°) | 18.1 | 2.1–60.2 | |
Average LL correction (°) | 7.6 | −15.6 to 36.6 |
Unless otherwise indicated, values are expressed as the number of patients and percentage.
A total of 36 patients underwent same-day posterior procedures (61.0%), whereas 23 patients underwent staged posterior procedures (39.0%). Posterior pedicle screw fixation was accomplished via an open (28 patients, 47.5%) or percutaneous (30 patients, 50.8%) technique. Within the percutaneous group, robot-assisted pedicle screw placement was used in 2 patients. One patient underwent a hybrid open and percutaneous posterior approach. When possible, autograft was used for fusion in addition to allograft (n = 22). A total of 19 patients (32.2%) underwent posterior column osteotomies at the time of posterior instrumentation. No patient underwent pedicle subtraction osteotomy. In addition, 4 patients (6.8%) underwent lumbar anterior ligament release via a lateral approach; none of these patients experienced approach-related complications. The average surgical time and estimated blood loss for the CaN LLIF portion on days in which the procedures were staged was 278.6 minutes (range 126–635 minutes) and 99.1 mL (range 20–345 mL), respectively (Table 2).
The average coronal Cobb angle correction was 18.1° (range 2.1°–60.2°) and lumbar lordosis correction was 7.6° (range −15.6° to 36.6°). Figures 1 and 2 illustrate patients from this series with kyphoscoliosis, exemplified by pre- and postoperative radiographs.
A 70-year-old woman with a history of multiple lumbar laminectomies presented with progressive back pain and lumbar radiculopathy. Serial imaging revealed progressive lumbar scoliosis, adult spinal deformity with PI-LL mismatch, and postlaminectomy syndrome (A and B). The patient underwent L1–5 LLIF; the operative time was 322 minutes, with an estimated blood loss of 25 mL. Two days later, open T12–L5 posterior instrumentation was performed; the operative time was 242 minutes, with an estimated blood loss of 350 mL (C and D).
A 71-year-old woman with kyphoscoliosis (69° thoracolumbar curve) presenting with back pain and lumbar radiculopathy (A and B) underwent T12–L5 LLIF; the operative time was 223 minutes, with an estimated blood loss of 50 mL. The next day, open T10–pelvis posterior instrumentation was performed; the operative time was 366 minutes, with an estimated blood loss of 2000 mL (C and D).
The average length of hospital stay for this population was 7.4 days (range 3–28 days). Of note, the patient who stayed for 28 days underwent a 2-level lateral interbody fusion with a 14-level posterior construct and experienced multiple complications delaying her discharge (Table 2).
A total of 6 intraoperative complications related to the LLIF stage occurred in 5 patients (8.5%) (Table 3). Of these, 3 were CaN-related, including a case in which inaccurate CaN resulted in a misplaced interbody cage oriented posteriorly. This cage was subsequently removed, and an expandable cage was placed with the aid of fluoroscopy. An unplanned intraoperative CT acquisition was performed, and the remaining interbody cages were placed without complication. In another case, an unplanned intraoperative CT acquisition was performed due to CaN inaccuracy (Table 3). Therefore, a total of 3 CaN-related intraoperative complications occurred in 2 patients (3.4%), with 1 misplaced lateral interbody cage (0.6% of 175 total lateral cages placed) requiring intraoperative revision. No patient required a return to the operating room for misplaced interbody cage.
Intraoperative and postoperative complications in 59 patients with LLIF
Complication Variables | No. of Patients | Percentage |
---|---|---|
Intraop complications (LLIF stage) | ||
Pleural violation | 2 | 3.4% |
Diaphragm tear | 1 | 1.7% |
Navigation-related | ||
Misplaced interbody cage, revised using fluoroscopy | 1 | 1.7%; 0.6%* |
No. of unplanned intraop CT acquisitions | 2 | 3.4% |
Intraop complications (posterior stage) | ||
Durotomy | 7 | 11.9% |
Navigation-related | ||
Breached pedicle screw, revised using fluoroscopy | 1 | 1.7% |
Number of unplanned intraop CT acquisitions | 4 | 6.8% |
LLIF approach–related postop complications | ||
Pneumothorax, pulmonary edema, & hypoxia respiratory failure | 1 | 1.7% |
Transient weakness | 12 | 20.3% |
Persistent weakness | 2 | 3.4% |
Transient numbness | 13 | 22.0% |
Persistent numbness | 7 | 11.9% |
Postop complications† | ||
Ileus | 9 | 15.3% |
Anemia requiring transfusion | 8 | 13.6% |
Urinary retention | 6 | 10.2% |
Superficial wound dehiscence | 2 | 3.4% |
Non–ST-elevation myocardial infarction | 2 | 3.4% |
Acute kidney injury | 2 | 3.4% |
Atrial fibrillation w/ rapid ventricular response | 2 | 3.4% |
Deep venous thromboembolism | 1 | 1.7% |
Other‡ | 4 | 6.8% |
Percentage of total lateral cages placed; 1/175.
Twenty-five total patients, with 9 patients having more than 1 complication.
Includes meningitis, pneumonia, viral conjunctivitis, and urinary tract infection.
The 3 remaining intraoperative complications related to the LLIF stage included 1 diaphragmatic tear (1.7%) repaired intraoperatively and 2 small pleural violations (3.4%). One patient with a small pleural violation developed postoperative complications as detailed below. The other 2 patients did not develop any complication sequela.
A total of 12 intraoperative complications related to the posterior instrumentation stage occurred in 11 patients (18.6%) (Table 3). A total of 5 were CaN-related including 1 incidence of pedicle screw breach. Further investigation demonstrated that the pedicle screws at this single level were inaccurately placed; 1 screw was medial and the contralateral screw was lateral. These screws were subsequently removed and replaced using a Jamshidi technique with K-wires and fluoroscopy without any neurological compromise. The remaining pedicle screws were successfully placed with CaN after another unplanned intraoperative CT scan was performed. In 3 separate cases, unplanned intraoperative CT acquisitions were obtained due to CaN inaccuracies. Therefore, a total of 5 CaN-related intraoperative complications occurred in 4 patients (6.8%) for the posterior instrumentation portion. The 7 remaining intraoperative complications were small durotomies (Table 3).
A binomial logistic regression analysis was performed to correlate different variables including age, gender, BMI, number of lateral interbody levels, number of posterior instrumentation levels, estimated blood loss, length of surgery, clinical symptoms, and open versus percutaneous approach. None of the independent variables reached statistical significance related to intraoperative and CaN-related complications for this surgical technique.
Postoperative complications related to the LLIF surgical approach included 1 patient with a small pleural violation who developed a pneumothorax (as described above), which resolved spontaneously. However, she subsequently developed pulmonary edema and respiratory failure, which extended her length of stay. Transient weakness in either hip flexion, knee extension, or dorsiflexion on the side of the LLIF surgery that was present postoperatively but resolved at the 1-month follow-up was noted in 12 patients (20.3%). Two patients (3.4%) continued to experience slight weakness with scores of 4+ in hip flexion at the time of the 1-month follow-up. Transient numbness in the lower extremity on the side of the LLIF surgery was reported in 13 patients (22.0%). A total of 7 patients (11.9%) continued to report some degree of numbness at the 1-month follow-up. However, this was not reported to be clinically significant.
Medical postoperative complications included 9 patients (15.3%) with postoperative ileus, 8 patients (13.6%) requiring transfusion, 6 patients (10.2%) with urinary retention, 2 patients (3.4%) with superficial posterior wound dehiscence treated with oral antibiotics, 2 patients (3.4%) with non–ST-elevation myocardial infarction, 2 patients (3.4%) with acute kidney injury, 2 patients (3.4%) with atrial fibrillation with rapid ventricular response, 1 patient (1.7%) with a deep venous thromoboembolism, and 4 patients with one of the following: meningitis, pneumonia, viral conjunctivitis, or urinary tract infection.
Discussion
The use of the LLIF technique to treat degenerative spinal conditions is gaining popularity, especially when coupled with CaN. We have previously reported on the feasibility of using CaN LLIF for treating degenerative disc disease.11 In the present study, we analyzed the feasibility of using CaN for multiple-level LLIF in patients with adult spinal deformity. We demonstrate that use of the CaN LLIF technique in spinal deformity is feasible, with an acceptable rate of intraoperative and CaN-related complications.
In this study we reported a total of 3 CaN-related complications associated with the LLIF portion occurring in 2 patients, and 5 CaN-related complications associated with the posterior instrumentation portion occurring in 4 patients. Our rate of CaN-related complications associated with the LLIF stage (2 of 59 patients, 3.4%; including 1 of 175 lateral interbody cages, 0.6%) is low and consistent with other techniques for interbody placement. Xi et al. demonstrated that use of CaN for the oblique lumbar interbody fusion (OLIF) technique resulted in an accuracy rate of 94.9%, as assessed by postoperative lateral radiographs.18 Whereas Xi et al. evaluated only OLIF, in our study we had 1 misplaced interbody cage requiring intraoperative modification using the LLIF technique, which we attributed to CaN inaccuracy. This single incident suggests that use of CaN for placement of lateral lumbar interbody cages in the adult spinal deformity population is safe and accurate. We were unable to identify any existing studies in which CaN-related LLIF complications including need to abandon CaN for fluoroscopy or number of unplanned intraoperative CT acquisitions were directly evaluated. This is the first study to evaluate such complications in the adult spinal deformity population. The accuracy of using CaN has been well studied for pedicle screw placement11,19–21 and our pedicle screw accuracy—although not the focus of this study—was high, with only 1 incident of breached pedicle screws requiring intraoperative modification.
We reported 2 pleural violations and 1 diaphragm tear during the LLIF approach. The complications were relatively benign, with only 1 of the pleural violations resulting in postoperative complications—with a pneumothorax, pulmonary edema, and respiratory failure. These complications have been previously reported in the literature related to the LLIF approach.22 Our rate of pleural complications (5.1%) is at the low end of published data, which ranges from 2.5%23 to 44%.24 In our study no patient required chest tube placement.
Reported cases of transient hip flexion numbness and weakness is a relatively common postoperative complication of the LLIF technique because the surgical corridor traverses through the psoas muscle.25–28 The numbness and/or weakness is usually transient, as reported in a study conducted by Cummock et al.29 in which up to 90% of patients reported symptom resolution at their 1-year follow-up. In our study, we report 12 patients (20.3%) with transient weakness and 13 patients (22.0%) with transient numbness, which is consistent with other reported studies with ranges from roughly 20% to 40% for weakness and numbness.25,29,30 Two patients (3.4%) experienced persistent weakness at the 1-month follow up. This is also consistent with reports in which the majority of patients experience complete resolution of their weakness.26 Interestingly, 7 patients (11.9%) were still experiencing numbness at the 1-month follow-up, which was an improvement of roughly 41%. The improvement in numbness observed in this study at 1-month follow-up is consistent with other reports in the literature. For example, Cummock et al. reported roughly 57% improvement in patients’ numbness at 3 months.29
We report a total of 37 postoperative complications in 25 patients (42.4%). Two patients experienced superficial wound dehiscence, which was treated with oral antibiotics. The remaining postoperative complications were medically related. Of note, the patient with the 28-day hospital stay experienced a durotomy intraoperatively. Furthermore, her hospital course was plagued with postoperative complications including postoperative ileus, urinary retention, anemia requiring transfusion, suspected meningitis, and a superficial wound dehiscence. She ultimately was discharged to a short-term acute-care hospital. This patient alone accounts for 6 of the total complications. Furthermore, 9 patients had more than 1 postoperative medially related complication.
The use of CaN in multiple-level LLIF for patients with adult spinal deformity has not been broadly adopted in comparison to fluoroscopy-based LLIF. A major advantage of CaN procedures is the reduction of fluoroscopy exposure of the surgeon. An additional advantage is the potential for improved surgical workflow, eliminating the need for the surgeon to wear lead and reducing the amount of intraoperative fluoroscope manipulation. Additionally, CaN-based LLIF may be superior to fluoroscopy in adult spinal deformity because the navigation can direct the approach to the coronally deformed spine and guide the cage placement between rotated vertebral bodies, maneuvers that can be a technical challenge. In order to maintain accuracy during a multiple-level LLIF procedure, we advocate performing the most rostral–level LLIF first and then proceeding sequentially caudally toward the navigation frame.
In our study, the average coronal Cobb angle correction was 18.1°. This correction is similar to other reported studies in which LLIF was used for deformity correction with a range of 9.8°–25.5°.4–6,31–33 The lumbar lordosis correction in our study was 7.6°. This is also consistent with previous reports ranging from 3.8° to 11° of lordosis correction.4–6,31–33
This study is limited by retrospective data collection from a single institution. The analysis focused on intraoperative and perioperative complications of the multiple-level CaN LLIF technique, and thus follow-up was limited. Potential late complications of the technique such as subsidence rate were not addressed. Additionally, long-term clinical outcomes were beyond the scope of this current study and further analysis is warranted. Last, our practice pattern is to obtain postoperative radiographs; CT scans were not routinely performed except in specific cases.
Conclusions
Use of CaN in multiple-level LLIF for adult spinal deformity is feasible. The rates of intraoperative and CaN-related complications were low and did not result in significant harm. Approach-related complications with weakness and numbness were consistent with previous reports.
Acknowledgments
We thank Tom Cichonski for editorial assistance.
Disclosures
Paul Park reports consultation work with Globus Medical and NuVasive and royalties received from Globus Medical for an unrelated device. He also reports non–study-related grants for research from DePuy and ISSG. Mark Oppenlander is a consultant for Globus Medical, DePuy Spine, and LifeNet Health.
Author Contributions
Conception and design: Oppenlander, Strong, Kashlan, Szerlip, Park. Acquisition of data: Strong, Yee, Khalsa, Saadeh, Swong. Analysis and interpretation of data: all authors. Drafting the article: Oppenlander, Strong, Yee, Khalsa, Saadeh, Swong. Critically revising the article: Oppenlander, Strong. Reviewed submitted version of manuscript: all authors. Approved the final version of the manuscript on behalf of all authors: Oppenlander. Statistical analysis: Oppenlander, Strong, Yee, Khalsa, Saadeh, Swong. Study supervision: Oppenlander.
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