Convection-enhanced delivery of immunotoxins and radioisotopes for treatment of malignant gliomas

William A. Vandergrift M.D. and Sunil J. Patel M.D.
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  • Division of Neurosurgery, Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina
Page Range:
E13
Volume/Issue:
Volume 20: Issue 4
DOI link:
https://doi.org/10.3171/foc.2006.20.4.8
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✓ The treatment of malignant gliomas has advanced significantly in the past 15 years. The simultaneous development of new targeting agents and techniques to deliver these high-molecular-weight compounds has led to improved efficacy and promising results in Phase III trials. Convection-enhanced delivery (CED) of macromolecules has emerged as the leading delivery technique for the treatment of malignant gliomas. A summary of the basic principles of CED and a review of the current human trials of protein targeting agents are provided.

Abbreviations used in this paper:

AA = anaplastic astrocytoma; BBB = blood–brain barrier; CED = convection-enhanced delivery; CNS = central nervous system; GBM = glioblastoma multiforme; IL = interleukin; mAb = monoclonal antibody; MR = magnetic resonance; SPECT = single-photon emission computerized tomography.

✓ The treatment of malignant gliomas has advanced significantly in the past 15 years. The simultaneous development of new targeting agents and techniques to deliver these high-molecular-weight compounds has led to improved efficacy and promising results in Phase III trials. Convection-enhanced delivery (CED) of macromolecules has emerged as the leading delivery technique for the treatment of malignant gliomas. A summary of the basic principles of CED and a review of the current human trials of protein targeting agents are provided.

Volume 20 (2006): Issue 4 (Apr 2006)

in Neurosurgical Focus
Cover Neurosurgical Focus

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