Pediatric sellar tumors: diagnostic procedures and management

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The diagnosis and management of pediatric sellar lesions is discussed in this paper. Craniopharyngiomas account for the majority of pediatric sellar masses, and pituitary adenomas are extremely uncommon during childhood. The diagnosis of sellar lesions involves a multidisciplinary effort, and detailed endocrinological, ophthalmological, and neurological testing is critical in the evaluation of a new sellar mass. The management of pituitary adenomas varies depending on the entity. For most tumors other than prolactinomas, transsphenoidal resection remains the mainstay of treatment. Less invasive methods, such as endoscopic transsphenoidal surgery and stereotactic radiosurgery, have shown promise as primary and adjuvant treatment modalities, respectively.

Abbreviations used in this paper:ACTH = adrenocorticotropic hormone; CD = Cushing's disease; FSH = follicle-stimulating hormone; GH = growth hormone; LH = luteinizing hormone; MR = magnetic resonance; PRL = prolactin; TSH = thyroid-stimulating hormone.

The diagnosis and management of pediatric sellar lesions is discussed in this paper. Craniopharyngiomas account for the majority of pediatric sellar masses, and pituitary adenomas are extremely uncommon during childhood. The diagnosis of sellar lesions involves a multidisciplinary effort, and detailed endocrinological, ophthalmological, and neurological testing is critical in the evaluation of a new sellar mass. The management of pituitary adenomas varies depending on the entity. For most tumors other than prolactinomas, transsphenoidal resection remains the mainstay of treatment. Less invasive methods, such as endoscopic transsphenoidal surgery and stereotactic radiosurgery, have shown promise as primary and adjuvant treatment modalities, respectively.

Abbreviations used in this paper:ACTH = adrenocorticotropic hormone; CD = Cushing's disease; FSH = follicle-stimulating hormone; GH = growth hormone; LH = luteinizing hormone; MR = magnetic resonance; PRL = prolactin; TSH = thyroid-stimulating hormone.

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Address reprint requests to: Edward R. Laws Jr., M.D., Department of Neurological Surgery, University of Virginia, PO Box 800212, Charlottesville, Virginia 22908-00212. email: el5g@virginia.edu
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