Idiopathic granulomatous hypophysitis

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A case is described of an elderly woman who presented with headaches, hypopituitarism, and visual disturbances and was found to have idiopathic granulomatous hypophysitis, a rare lesion of the pituitary gland. Preoperative magnetic resonance imaging demonstrated a well-circumscribed lesion, which was isointense on both T1- and T2-weighted imaging and enhanced uniformly with administration of gadolinium contrast enhancement, not unlike a macroadenoma. The present case and 12 other cases from the literature are reviewed.

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Address reprint requests to: Michael H. Brisman, M.D., Department of Neurosurgery, The Mount Sinai Hospital, 1 Gustave Levy Place, New York, New York, 10029.

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