Pathophysiology of peripheral nerve injury: a brief review

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Clinicians caring for patients with brachial plexus and other nerve injuries must possess a clear understanding of the peripheral nervous system's response to trauma. In this article, the authors briefly review peripheral nerve injury (PNI) types, discuss the common injury classification schemes, and describe the dynamic processes of degeneration and reinnervation that characterize the PNI response.

Abbreviations used in this paper:CNS = central nervous system; NGF = nerve growth factor; PNI = peripheral nerve injury.

Clinicians caring for patients with brachial plexus and other nerve injuries must possess a clear understanding of the peripheral nervous system's response to trauma. In this article, the authors briefly review peripheral nerve injury (PNI) types, discuss the common injury classification schemes, and describe the dynamic processes of degeneration and reinnervation that characterize the PNI response.

Abbreviations used in this paper:CNS = central nervous system; NGF = nerve growth factor; PNI = peripheral nerve injury.

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Contributor Notes

Address reprint requests to: Mark G. Burnett, M.D., Department of Neurosurgery, Hospital of the University of Pennsylvania, Silverstein Building 5th Floor, 3400 Spruce Street, Philadelphia, Pennsylvania 19104. email: burnettmg@hotmail.com.

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