Top 25 Cited Gamma Knife® Surgery Articles - Trigeminal Neuralgia

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Bradley Nicol, William F. Regine, Claire Courtney, Ali Meigooni, Michael Sanders, and Byron Young

Object. The purpose of this paper was to assess the treatment of trigeminal neuralgia (TN) with the higher than normal dose of 90 Gy.

Methods. Forty-two patients with typical TN were treated over a 3-year period with gamma knife radiosurgery. Every patient received a maximum dose of 90 Gy in a single 4-mm isocenter targeted to the root entry zone of the trigeminal nerve. Thirty of 42 patients had undergone no prior treatments. The median follow-up period was 14 months (range 2–30 months).

Thirty-one patients (73.8%) achieved complete relief of pain. Nine patients (21.4%) obtained good pain control. Complications were limited to increased facial paresthesia in seven patients (16.7%) and dysgeusia in four patients (9.5%).

Conclusions. The authors conclude that the use of 90 Gy is a safe and effective dose for the treatment of TN.