Association between urinary oxytocin secretion and natriuresis after transsphenoidal pituitary surgery

Paul E. ConstanthinDepartment of Neurosurgery and
Faculty of Medicine, Université de Genève (UNIGE);

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Nathalie IsidorClinical Investigation Unit, Clinical Research Center, University of Geneva, Hôpitaux Universitaires de Genève (HUG); and

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Sophie De SeigneuxDepartment of Nephrology, Hôpitaux Universitaires de Genève (HUG), Geneva, Switzerland

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Shahan MomjianDepartment of Neurosurgery and
Faculty of Medicine, Université de Genève (UNIGE);

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Publication Date:
19 May 2023
Page Range:
1–7
Volume/Issue:
Publish Before Print
DOI link:
https://doi.org/10.3171/2023.4.JNS23100
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OBJECTIVE

Oxytocin (OXT) secretion has been shown to be abnormally elevated in patients who develop syndrome of inappropriate secretion of antidiuretic hormone (SIADH)–related hyponatremia after transsphenoidal pituitary surgery (TPS). While OXT was previously reported to increase natriuresis in the kidney, a potential role for this hormone in postoperative sodium balance and dysnatremias has not been studied. The objective of this study was to analyze the correlation between patients’ urinary output of OXT and natremia and natriuresis after TPS.

METHODS

The authors measured and correlated the urinary output of OXT with natriuresis and natremia in 20 consecutive patients who underwent TPS.

RESULTS

The ratio of urinary secretion of OXT between days 1 and 4 showed a strong, significant correlation with patient natriuresis at day 7 after pituitary surgery. Concomitantly, patient natremia showed a moderate, inverted correlation with OXT secretion in the urine.

CONCLUSIONS

Together, these results show for the first time that urinary OXT secretion correlates with patient natriuresis and natremia after pituitary surgery. This observation suggests a notable role for this hormone in sodium balance.

ABBREVIATIONS

ACTH = adrenocorticotropic hormone; ANP = atrial natriuretic peptide; AVP = arginine vasopressin; CSW = cerebral salt wasting; DI = diabetes insipidus; FE urates = ejection fraction of urates; GH = growth hormone; IQR = interquartile range; OXT = oxytocin; PRL = prolactin; SIADH = syndrome of inappropriate secretion of antidiuretic hormone; SIOXT = syndrome of inappropriate secretion of OXT; TPS = transsphenoidal pituitary surgery; TSH = thyroid-stimulating hormone.
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Contributor Notes

Correspondence Shahan Momjian: Hôpitaux Universitaires de Genève, Université de Genève, Geneva, Switzerland. shahan.momjian@hcuge.ch.

INCLUDE WHEN CITING Published online May 19, 2023; DOI: 10.3171/2023.4.JNS23100.

Disclosures The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper.

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