Letter to the Editor. Biologically effective dose and the treatment of AVMs

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  • 6 Green Templeton College, University of Oxford, United Kingdom
  • 7 Gamma Knife Centre, National Hospital for Neurology and Neurosurgery, London, United Kingdom
  • 8 Gray Laboratory, CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, United Kingdom
  • 9 Wellcome/EPSRC Centre for Interventional and Surgical Sciences, University College London, United Kingdom
  • 10 Centre for Medical Image Computing, University College London, United Kingdom
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Contributor Notes

Correspondence John W. Hopewell: john.hopewell@gtc.ox.ac.uk.

INCLUDE WHEN CITING Published online January 22, 2021; DOI: 10.3171/2020.9.JNS203545.

Disclosures Mr. Paddick: consultant for Elekta AB.

  • 1

    Tuleasca C, Peciu-Florianu I, Leroy H-A, Biologically effective dose and prediction of obliteration of unruptured arteriovenous malformations treated by upfront Gamma Knife radiosurgery: a series of 149 consecutive cases. J Neurosurg. Published online July 24, 2020. doi:10.3171/2020.4.JNS201250

    • Search Google Scholar
    • Export Citation
  • 2

    Hopewell JW, Millar WT, Lindquist C. Radiobiological principles: their application to γ knife therapy. Prog Neurol Surg. 2012;25:3954.

    • Search Google Scholar
    • Export Citation
  • 3

    Hopewell JW, Millar WT, Lindquist C, Application of the concept of biologically effective dose (BED) to patients with vestibular schwannomas treated by radiosurgery. J Radiosurg SBRT. 2013;2(4):257271.

    • Search Google Scholar
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  • 4

    Millar WT, Hopewell JW, Paddick I, The role of the concept of biologically effective dose (BED) in treatment planning in radiosurgery. Phys Med. 2015;31(6):627633.

    • Search Google Scholar
    • Export Citation
  • 5

    Tuleasca C, Paddick I, Hopewell JW, Establishment of a therapeutic ratio for Gamma Knife radiosurgery of trigeminal neuralgia: the critical importance of biologically effective dose versus physical dose. World Neurosurg. 2020;134:e204e213.

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    • Export Citation
  • 6

    Régis J, Tuleasca C, Hopewell JW, Castinetti F. Commentary: The impact of insulin-like growth factor index and biologically effective dose on outcomes after stereotactic radiosurgery for acromegaly: cohort study. Neurosurgery. 2020;87(3):E301E302.

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    • Export Citation
  • 7

    Millar WT, Canney PA. Derivation and application of equations describing the effects of fractionated protracted irradiation, based on multiple and incomplete repair processes. Part I. Derivation of equations. Int J Radiat Biol. 1993;64(3):275291.

    • Search Google Scholar
    • Export Citation
  • 8

    Jones B, Hopewell JW. Modelling the influence of treatment time on the biological effectiveness of single radiosurgery treatments: derivation of “protective” dose modification factors. Br J Radiol. 2019;92(1093):20180111.

    • Search Google Scholar
    • Export Citation
  • 9

    Klinge T, Modat M, McClelland, The impact of unscheduled gaps and iso-centre sequencing on the biologically effective dose in Gamma Knife radiosurgery. J Radiosurg SBRT. In press.

    • Search Google Scholar
    • Export Citation
  • 10

    Graffeo CS, Donegan D, Erickson D, The impact of insulin-like growth factor index and biologically effective dose on outcomes after stereotactic radiosurgery for acromegaly: cohort study. Neurosurgery. 2020;87(3):538546.

    • Search Google Scholar
    • Export Citation
  • 1

    Karlsson B, Lax I, Yamamoto M, Calculation of isoeffective doses and the alpha/beta value by comparing results following radiosurgery and radiotherapy for arteriovenous malformations of the brain. J Neurosurg. 2006;105(suppl):183189.

    • Search Google Scholar
    • Export Citation
  • 2

    Larson DA, Flickinger JC, Loeffler JS. The radiobiology of radiosurgery. Int J Radiat Oncol Biol Phys. 1993;25(3):557561.

  • 3

    Hopewell JW, Millar WT, Lindquist C, Application of the concept of biologically effective dose (BED) to patients with vestibular schwannomas treated by radiosurgery. J Radiosurg SBRT. 2013;2(4):257271.

    • Search Google Scholar
    • Export Citation
  • 4

    Tuleasca C, Paddick I, Hopewell JW, Establishment of a therapeutic ratio for Gamma Knife radiosurgery of trigeminal neuralgia: the critical importance of biologically effective dose versus physical dose. World Neurosurg. 2020;134:e204e213.

    • Search Google Scholar
    • Export Citation
  • 5

    Millar WT, Hopewell JW, Paddick I, The role of the concept of biologically effective dose (BED) in treatment planning in radiosurgery. Phys Med. 2015;31(6):627633.

    • Search Google Scholar
    • Export Citation
  • 6

    Régis J, Tuleasca C, Hopewell JW, Castinetti F. Commentary: The impact of insulin-like growth factor index and biologically effective dose on outcomes after stereotactic radiosurgery for acromegaly: cohort study. Neurosurgery. 2020;87(3):E301E302.

    • Search Google Scholar
    • Export Citation
  • 7

    Regis J, Tamura M, Guillot C, Radiosurgery with the world’s first fully robotized Leksell Gamma Knife PerfeXion in clinical use: a 200-patient prospective, randomized, controlled comparison with the Gamma Knife 4C. Neurosurgery. 2009;64(2):346356.

    • Search Google Scholar
    • Export Citation
  • 8

    Moeller BJ, Dreher MR, Rabbani ZN, Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. Cancer Cell. 2005;8(2):99110.

  • 1

    Millar WT, Canney PA. Derivation and application of equations describing the effects of fractionated protracted irradiation, based on multiple and incomplete repair processes. Part I. Derivation of equations. Int J Radiat Biol. 1993;64(3):275291.

    • Search Google Scholar
    • Export Citation
  • 2

    Hall EJ, Brenner DJ. The radiobiology of radiosurgery: rationale for different treatment regimes for AVMs and malignancies. Int J Radiat Oncol Biol Phys. 1993;25(2):381385.

    • Search Google Scholar
    • Export Citation
  • 3

    Jones B, Hopewell JW. Modelling the influence of treatment time on the biological effectiveness of single radiosurgery treatments: derivation of “protective” dose modification factors. Br J Radiol. 2019;92(1093):20180111.

    • Search Google Scholar
    • Export Citation
  • 4

    Millar WT, Hopewell JW, Paddick I, The role of the concept of biologically effective dose (BED) in treatment planning in radiosurgery. Phys Med. 2015;31(6):627633.

    • Search Google Scholar
    • Export Citation
  • 5

    Graffeo CS, Donegan D, Erickson D, The impact of insulin-like growth factor index and biologically effective dose on outcomes after stereotactic radiosurgery for acromegaly: cohort study. Neurosurgery. 2020;87(3):538546.

    • Search Google Scholar
    • Export Citation
  • 6

    Karlsson B, Lax I, Yamamoto M, Calculation of isoeffective doses and the alpha/beta value by comparing results following radiosurgery and radiotherapy for arteriovenous malformations of the brain. J Neurosurg. 2006;105(suppl):183189.

    • Search Google Scholar
    • Export Citation

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