Intracranial EEG and laser interstitial thermal therapy in MRI-negative insular and/or cingulate epilepsy: case series

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  • 1 Epilepsy Center, Neuroscience Institute, AdventHealth;
  • 2 Department of Neurosurgery, Neuroscience Institute, AdventHealth;
  • 3 Department of Neuropsychology, Neuroscience Institute, AdventHealth;
  • 4 MEG Center, Neuroscience Institute, AdventHealth; and
  • 5 Department of Radiology, AdventHealth, Orlando, Florida
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OBJECTIVE

The goal of this study was to assess the success rate and complications of stereo-electroencephalogra-phy (sEEG) and laser interstitial thermal therapy (LITT) in the treatment of nonlesional refractory epilepsy in cingulate and insular cortex.

METHODS

The authors retrospectively analyzed the treatment response in 9 successive patients who underwent insular or cingulate LITT for nonlesional refractory epilepsy at their center between 2011 and 2019. Localization of seizures was based on inpatient video-EEG monitoring, neuropsychological testing, 3-T MRI, PET scan, magnetoencephalography scan, and/or ictal SPECT scan. Eight patients underwent sEEG, and 1 patient had implantation of both sEEG electrodes and subdural grids for localization of epileptogenic zones. LITT was performed in 5 insular cases (4 left and 1 right) and 3 cingulate cases (all left-sided). One patient also underwent both insular and cingulate LITT on the left side. All of the patients who underwent insular LITT as well as 2 of the 3 who underwent cingulate LITT were right-hand dominant. The patient who underwent insular plus cingulate LITT was also right-hand dominant.

RESULTS

Following LITT, 67% of the patients were seizure free (Engel class I) at follow-up (mean 1.35 years, range 0.6–2.8 years). All patients responded favorably to treatment (Engel class I–III). Two patients developed small intracranial hemorrhages during the sEEG implantation that did not require surgical management. One patient developed a large intracranial hemorrhage during an insular LITT procedure that did require surgical management. That patient experienced aphasia, incoordination, and hemiparesis, which resolved with inpatient rehabilitation. No permanent neurological deficits were noted in any of the patients at last follow-up. Neuropsychological status was stable in this cohort before and after LITT.

CONCLUSIONS

sEEG can be safely used to localize seizures originating from insular and cingulate cortex. LITT can successfully treat seizures arising from these deep-seated structures. The insula and cingulum should be evaluated more frequently for seizure onset zones.

ABBREVIATIONS DRE = drug-resistant epilepsy; FSIQ = full-scale IQ; iMRI = intraoperative MRI; LITT = laser interstitial thermal therapy; MEG = magnetoencephalogra-phy; OR = operating room; RFTC = radiofrequency thermocoagulation; sEEG = stereo-electroencephalography; SMA = supplementary motor area.

Supplementary Materials

    • Supplemental Tables and Figures (PDF 1.53 MB)

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Contributor Notes

Correspondence Elakkat D. Gireesh: Neuroscience Institute, AdventHealth, Orlando, FL. elakkat.gireesh.md@adventhealth.com.

INCLUDE WHEN CITING Published online December 11, 2020; DOI: 10.3171/2020.7.JNS201912.

Disclosures Dr. Baumgartner has served as a paid consultant for PMT Corp., iMRIs, Monteris, and Zimmer-Biomet.

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