Spatial convergence of distant cortical regions during folding explains why arteries do not cross the sylvian fissure

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  • 1 Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania;
  • 2 Department of Physics, FCEN, University of Buenos Aires and IFIBA-CONICET, Buenos Aires, Argentina;
  • 3 Department of Neurosurgery, Hospital El Cruce, Florencio Varela, Provincia de Buenos Aires, Argentina; and
  • 4 University of Pittsburgh Medical School, Pittsburgh, Pennsylvania
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OBJECTIVE

Cortical folding places regions that are separated by a large distance along the cortical surface in close proximity. This process is not homogeneous; regions such as the insular opercula have a much higher cortical surface distance (CSD) to euclidean distance (ED) than others. Here the authors explore the hypothesis that in the folded brain the CSD, and not the ED, determines regions of common irrigation, because this measure corresponds more closely with the distance along the prefolded brain, where the subarachnoid arterial vascular network starts forming.

METHODS

The authors defined a convergence index that compared the ED to the CSD and applied it to the cortical surface reconstruction of an average brain. They then compared cortical convergence to the irrigation patterns of major sulci and fissures of the brain, by assessing whether these structures were crossed or not crossed by arterial vessels in 20 fixed hemispheres.

RESULTS

The regions of highest convergence (top 1%) were clustered around the sylvian fissure, which is the only brain depression with high convergence values along its edges. Arterial crossings were commonly observed in every major sulcus of the brain, with the exception of the sylvian fissure, constituting a highly significant difference (p < 10−4).

CONCLUSIONS

Arteries do not cross regions of high convergence. In the adult brain the CSD, rather than the ED, predicts the regional irrigation pattern. The distant origin of the frontal and temporal lobes creates a region of high cortical convergence, which explains why arteries do not cross the sylvian fissure.

ABBREVIATIONS ACA = anterior cerebral artery; CSD = cortical surface distance; ED = euclidean distance; MCA = middle cerebral artery; PCA = posterior cerebral artery; PMA = postmenstrual age.

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Contributor Notes

Correspondence Ezequiel Goldschmidt: University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center, UPMC Presbyterian Hospital, Pittsburgh, PA. goldschmidted@upmc.edu.

INCLUDE WHEN CITING Published online November 22, 2019; DOI: 10.3171/2019.9.JNS192151.

Disclosures Dr. Friedlander is a consultant for NeuBase Therapeutics and DiFusion, Inc., and he also has direct stock ownership in both companies.

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