Editorial. Choices in clinical trial design

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Article Information

Correspondence Bob S. Carter: bcarter@mgh.harvard.edu.

ACCOMPANYING ARTICLE DOI: 10.3171/2018.11.JNS182713.

INCLUDE WHEN CITING Published online September 13, 2019; DOI: 10.3171/2019.7.JNS183276.

Disclosures The authors report no conflict of interest.

© AANS, except where prohibited by US copyright law.

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References

  • 1

    Amrein KSchnedl CHoll ARiedl RChristopher KBPachler C: Effect of high-dose vitamin D3 on hospital length of stay in critically ill patients with vitamin D deficiency: the VITdAL-ICU randomized clinical trial. JAMA 312:152015302014

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 2

    Cook JAHislop JAltman DGFayers PBriggs AHRamsay CR: Specifying the target difference in the primary outcome for a randomised controlled trial: guidance for researchers. Trials 16:122015

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 3

    Horton R: From star signs to trial guidelines. Lancet 355:103310342000

  • 4

    Karsy MGuan JEli IBrock AAMenacho STPark MS: The effect of supplementation of vitamin D in neurocritical care patients with hypovitaminosis D: RandomizEd Clinical TrIal oF hYpovitaminosis D (RECTIFY). J Neurosurg [epub ahead of print September 13 2019; DOI: 10.3171/2018.11.JNS182713]

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 1

    Amrein KSchnedl CHoll ARiedl RChristopher KBPachler C: Effect of high-dose vitamin D3 on hospital length of stay in critically ill patients with vitamin D deficiency: the VITdAL-ICU randomized clinical trial. JAMA 312:152015302014

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 2

    Bikle D: Nonclassic actions of vitamin D. J Clin Endocrinol Metab 94:26342009

  • 3

    Brustad NEliasen AUStokholm JBonnelykke KBisgaard HChawes BL: High-dose vitamin D supplementation during pregnancy and asthma in offspring at the age of 6 years. JAMA 321:100310052019

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 4

    Guan JKarsy MBrock AAEli IMLedyard HKHawryluk GW: A prospective analysis of hypovitaminosis D and mortality in 400 patients in the neurocritical care setting. J Neurosurg 127:172017

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 5

    Guan JKarsy MBrock AAEli IMManton GMLedyard HK: Vitamin D status and 3-month Glasgow Outcome Scale scores in patients in neurocritical care: prospective analysis of 497 patients. J Neurosurg 128:163516412018

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 6

    Guan JKarsy MEli IBisson EFMcNally STaussky P: Increased incidence of hypovitaminosis D among patients requiring treatment for cerebral aneurysms. World Neurosurg 88:15202016

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 7

    Ng KNimeiri HSMcCleary NJAbrams TAYurgelun MBCleary JM: Effect of high-dose vs standard-dose vitamin D3 supplementation on progression-free survival among patients with advanced or metastatic colorectal cancer: the SUNSHINE Randomized Clinical Trial. JAMA 321:137013792019

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 8

    Ravindra VMGodzik JGuan JDailey ATSchmidt MHBisson EF: Prevalence of vitamin D deficiency in patients undergoing elective spine surgery: a cross-sectional analysis. World Neurosurg 83:111411192015

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 9

    Thacher TDClarke BL: Vitamin D insufficiency. Mayo Clin Proc 86:50602011

  • 10

    Urashima MOhdaira HAkutsu TOkada SYoshida MKitajima M: Effect of vitamin D supplementation on relapse-free survival among patients with digestive tract cancers: the AMATERASU Randomized Clinical Trial. JAMA 321:136113692019

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation

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