Age dependency and modification of the Subarachnoid Hemorrhage Early Brain Edema Score

Restricted access

JNS + Pediatrics - 1 year subscription bundle (Individuals Only)

USD  $505.00

JNS + Pediatrics + Spine - 1 year subscription bundle (Individuals Only)

USD  $600.00


The Subarachnoid Hemorrhage Early Brain Edema Score (SEBES) system measures cerebral edema on CT and can be used to predict outcome after subarachnoid hemorrhage (SAH). The authors developed a modified SEBES (SEBES 6c) and assessed whether it could predict outcome after SAH better than the SEBES. Furthermore, they verified the age dependency of these scores.


In this retrospective study, all patients with aneurysmal SAH in the period from January 2011 to February 2017 at a single institution were analyzed. The SEBES, which is based on the absence of visible sulci at two defined CT levels (0–4 points), and the SEBES 6c were determined from the initial CT. The SEBES 6c system includes the two levels from the original SEBES and one level located 2 cm below the vertex (0–6 points). The authors investigated whether the various SEBESs are age dependent and if they can predict delayed infarction (DI) and outcome.


Two hundred sixty-one patients met the study inclusion criteria. The SEBES was an independent predictor for DI (OR 1.6 per 1-point increase) and unfavorable outcome (OR 1.36 per 1-point increase), in accordance with findings in the first publication on SEBES. However, here the authors found that the SEBES was age dependent. In the age group younger than 60 years, the patients with high-grade SEBESs (3–4 points) had DIs and unfavorable outcomes significantly more often than the patients with low-grade scores (0–2 points). In the age groups 60–69 years and ≥ 70 years, no significant differences in DI and outcome were identified between high-grade and low-grade scores, although trends toward DI and unfavorable outcomes among the 60–69 age group were noted in patients with high-grade SEBESs.

Receiver operating characteristic curve analysis showed that SEBES 6c had a higher prognostic value in predicting outcome than SEBES (p < 0.001). Furthermore, SEBES 6c predicted an unfavorable outcome (OR 1.31 per 1-point increase) and DI (OR 1.36 per 1-point increase) independent of vasospasms. SEBES 6c showed an age dependency similar to that of SEBES.


SEBES 6c is more suitable for predicting outcome after SAH than SEBES. Furthermore, it predicts outcome and DI independently of vasospasm, so it can be used to differentiate between early brain injury– and vasospasm-dependent infarctions and outcome. However, SEBES and SEBES 6c are both age dependent and can be used for patients aged < 60 years and may have limited suitability for patients aged 60–69 years and no suitability for patients aged ≥ 70 years.

ABBREVIATIONS AUC = area under the curve; CVS = cerebral vasospasm; DCI = delayed cerebral ischemia; DI = delayed infarction; EBI = early brain injury; mRS = modified Rankin Scale; ROC = receiver operating characteristic; SAH = subarachnoid hemorrhage; SEBES = Subarachnoid Hemorrhage Early Brain Edema Score; WFNS = World Federation of Neurosurgical Societies.

Supplementary Materials

  • Supplemental Figures and Tables (PDF 554 KB)
Article Information

Contributor Notes

Correspondence Michael Eibach: Goethe-University, Frankfurt am Main, Germany. WHEN CITING Published online March 20, 2020; DOI: 10.3171/2019.12.JNS192744.Disclosures The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper.


All Time Past Year Past 30 Days
Abstract Views 502 502 502
Full Text Views 65 65 65
PDF Downloads 62 62 62
EPUB Downloads 0 0 0
Google Scholar