Combined use of minimal access craniotomy, intraoperative magnetic resonance imaging, and awake functional mapping for the resection of gliomas in 61 patients

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OBJECTIVE

Current management of gliomas involves a multidisciplinary approach, including a combination of maximal safe resection, radiotherapy, and chemotherapy. The use of intraoperative MRI (iMRI) helps to maximize extent of resection (EOR), and use of awake functional mapping supports preservation of eloquent areas of the brain. This study reports on the combined use of these surgical adjuncts.

METHODS

The authors performed a retrospective review of patients with gliomas who underwent minimal access craniotomy in their iMRI suite (IMRIS) with awake functional mapping between 2010 and 2017. Patient demographics, tumor characteristics, intraoperative and postoperative adverse events, and treatment details were obtained. Volumetric analysis of preoperative tumor volume as well as intraoperative and postoperative residual volumes was performed.

RESULTS

A total of 61 patients requiring 62 tumor resections met the inclusion criteria. Of the tumors resected, 45.9% were WHO grade I or II and 54.1% were WHO grade III or IV. Intraoperative neurophysiological monitoring modalities included speech alone in 23 cases (37.1%), motor alone in 24 (38.7%), and both speech and motor in 15 (24.2%). Intraoperative MRI demonstrated residual tumor in 48 cases (77.4%), 41 (85.4%) of whom underwent further resection. Median EOR on iMRI and postoperative MRI was 86.0% and 98.5%, respectively, with a mean difference of 10% and a median difference of 10.5% (p < 0.001). Seventeen of 62 cases achieved an increased EOR > 15% related to use of iMRI. Seventeen (60.7%) of 28 low-grade gliomas and 10 (30.3%) of 33 high-grade gliomas achieved complete resection. Significant intraoperative events included at least temporary new or worsened speech alteration in 7 of 38 cases who underwent speech mapping (18.4%), new or worsened weakness in 7 of 39 cases who underwent motor mapping (18.0%), numbness in 2 cases (3.2%), agitation in 2 (3.2%), and seizures in 2 (3.2%). Among the patients with new intraoperative deficits, 2 had residual speech difficulty, and 2 had weakness postoperatively, which improved to baseline strength by 6 months.

CONCLUSIONS

In this retrospective case series, the combined use of iMRI and awake functional mapping was demonstrated to be safe and feasible. This combined approach allows one to achieve the dual goals of maximal tumor removal and minimal functional consequences in patients undergoing glioma resection.

ABBREVIATIONS ADC = apparent diffusion coefficient; DTI = diffusion tensor imaging; DVT = deep vein thrombosis; DWI = diffusion-weighted imaging; ECoG = electrocorticography; EMR = electronic medical record; EOR = extent of resection; fMRI = functional MRI; iMRI = intraoperative MRI; IMRIS = iMRI suite; IV = intravenous; KPS = Karnofsky Performance Scale; LMA = laryngeal mask airway; MPRAGE = magnetization prepared rapid gradient echo; OR = operating room; SMA = supplementary motor area.

Article Information

Correspondence Michael A. Vogelbaum: Moffitt Cancer Center, Tampa, FL. michael.vogelbaum@moffitt.org.

INCLUDE WHEN CITING Published online January 25, 2019; DOI: 10.3171/2018.9.JNS181802.

B.B.W. and B.S.L. share first authorship of this work.

Disclosures The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper.

© AANS, except where prohibited by US copyright law.

Headings

Figures

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    Preoperative MR images demonstrating the tumor before resection (A), and intra- (B) and postoperative (C) MR images showing residual tumor after resection. All measurements were made with a semiautomated volumetric analysis tool (BrainLAB iPlan). Arrows denote residual tumor volume.

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    A: Sterile surgical prepping and draping performed with access to the patient’s face and airway. B: A 2 × 6 ECoG grid placed subdurally and oriented to cover the eloquent area for adequate awake functional mapping. C: Tumor resection performed with circumferential dissection and occasional internal debulking after confirmation of noneloquent location with imaging guidance, awake functional mapping, and white matter stimulation with Ojemann bipolar stimulator. D: Intraoperative MRI brought into the operative field for radiographic evaluation after resection. Figure is available in color online only.

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