Intracranial follicular dendritic cell sarcoma

Case report

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✓✓ Intracranial occurrence of follicular dendritic cell (FDC) sarcoma, a rare tumor derived from dendritic cells of the lymphoid follicle, has not yet been described. Therefore, the case of a 53-year-old man presenting with an intracranial mass invading the clivus is reported. The diagnosis of FDC sarcoma was confirmed by immunohistochemical staining for dendritic cell markers, that is, CD21, CD23, and CD35. Due to some similarities with meningioma, intracranial FDC sarcoma might be an underdiagnosed disease.

Article Information

Address reprint requests to: Martin Hasselblatt, M.D., Institute of Neuropathology, University Hospital Münster, Domagkstrasse 19, 48149 Münster, Germany. email: hasselblatt@uni-muenster.de.

© AANS, except where prohibited by US copyright law.

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Figures

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    Coronal T1-weighted spin echo (A) and Gd-enhanced transverse T1-weighted spin echo (B) MR images depicting a strongly enhancing mass infiltrating the clivus and ensheathing the internal carotid artery.

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    Photomicrographs showing tumor cells forming clusters and vague whorls; note the lymphocytic infiltrates (A). At higher magnification, nuclei displaying thin nuclear membranes, clear chromatin, and small nucleoli are demonstrated (B). Tumor cells show strong immunoreactivity for CD21 (C). Hematoxylin, original magnifications × 100 (A and C) and × 400 (B).

References

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